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The map label for this gene is hmuR

Identifier: 218927490

GI number: 218927490

Start: 282991

End: 285021

Strand: Reverse

Name: hmuR

Synonym: YPO0283

Alternate gene names: 218927490

Gene position: 285021-282991 (Counterclockwise)

Preceding gene: 218927491

Following gene: 218927489

Centisome position: 6.12

GC content: 50.76

Gene sequence:

>2031_bases
ATGCTTCGTTCCACTTCCGACCGTTTCCGCTGGTCCTCACTCAGTTTGGCAATCGCTTGTACCTTGCCCCTTGCTACTCA
AGCTGCTGATACCACAACCACTCAAACCAGCAGTAAAAAGCACAGCACCGACACCATGGTCGTCACAGCAACCGGTAATG
AGCGTAGCAGTTTTGAAGCGCCAATGATGGTAACGGTCATCGAAGGGAATGCCCCTACCAGCCAAACCGCCGCGACGGCC
GCAGATATGCTGCGACAAGTACCAGGGCTGACCGTCACTGGCAGCGGGCGTACCAACGGTCAAGATGTGGTGATGCGAGG
TTACGGTAAACAAGGCGTGTTGACACTGGTTGATGGTGTTCGTCAGGGGACCGATACCGGTCACTTGAACTCCACTTTCC
TCGATCCTGCGTTAGTCAAACGTATCGAAATCGTCCGTGGGCCAGCAGCACTGCTGTACGGCAGTGGCGCTCTCGGCGGG
GTTATTGCCTATGAAACCGTGGATGCAGCGGACATGCTGCAACCGGGCCAAAACAGTGGTTATCGGGTTTACAGCTCTGC
CGCAACGGGTGATCACAGCTTCGGTCTGGGAGCCAGCGCCTTTGGCCGCACCGATGATCTGGATGGTATCCTCTCTTTCG
GTACCCGTGATATCGGCAACATTCGTCAAAGCAACGGTTTTAATGCCCCGAATGATGAAACTATCAGTAATGTATTGGCA
AAAGGCACTTGGCAGATAGACTCGATTCAATCGTTAAGCGCCAATCTGCGTTATTACAACAACAGTGCAATAGAGCCAAA
GAATCCGCAAACCAGCGCACCATCCAGTACCAATGTCATGACCAATCGTTCAACGATCCAGCGTGATGCCCAGCTCAGAT
ATAATATTAAGCCTCTCGATCAAGAATGGTTGAATGCCACGGCACAGGTTTATTACTCCGAAGTGGAAATCAATGCCCGT
CCACAAGGTTCAGCCGAAGAAGGCCGCGAGCAGACAACCGAAGGTGTGAAGCTGGAAAACCGTACCCGTCTGTTTATCGA
AAGCCCAGCCTCCCACTTGCTGACCTATGGTACTGAAACCTATAAACAGGAACAGACCCCCGGTGGGGCAACGGAAAGTT
TCCCACAGGCCAAAATTCGGTTTAGTTCGGGCTGGCTACAAGATGAAATCACCTTACGCGACCTGCCTGTCTCCATATTA
GCCGGTACGCGTTATGACAATTACAGTGGTAGCAGCGATGGCTATGCCGATGTCGATGCCGATAAATGGTCATCACGTGG
TGCAATCAGCATTACACCAACTGATTGGCTGATGCTGTTTGGCTCCTATGCTCAGGCTTTCCGCGCCCCAACCATGGGTG
AGATGTATAACGATTCCAAACACTTTGCGATCCCTATCCGGCCTGGGTTGACACTCACCAACTATTGGGTCCCCAACCCA
AATCTGAAACCAGAAACCAATGAGACCCAGGAATACGGTTTTGGCCTACGTTTCAGTGATTTACTGATGGCTGAAGATGA
CCTGCAATTTAAAGTCAGTTACTTCGATACCAAGGCTAAAGACTACATCAGTACCCGCGTTGACATGCAAGCCATGACCA
CCACATCGGTGAATATCGATCAGGCAAAAATCTGGGGTTGGGATGCCAGCATGAGCTATAAAACGGCCTTGTTTAACTGG
GATCTGGCCTATAACCGCACCCGTGGTAAAAATCAGAATACCGATGAATGGCTCGACACCATCAACCCGGATACCGTCAC
CAGTATCGTTGATGTACCTGTCGCCAACAGTGGTTTCTCCGTCGGTTGGATTGGGACCTTCGCTAATCGCTCCAGCCGCG
TTTCCAGTTCAACACCGCAAGCCGGTTATGGCGTCAATGATTTCTATGTGAGCTATAAAGGCCAGGAAGCATTCAAAGGC
ATGACCACAACAATGTTATTGGGTAATGTCTTCGAAAAAGAGTATTACACGCCACAAGGCATCCCACAAGATGGCCGTAA
CGTGAAATTTTTCGTGAGTTATCAGTGGTAG

Upstream 100 bases:

>100_bases
GGTATGAATGACGCTTACTGCAAGCCACCCAGATTTTCGAATCAAGGCAGCCAGCAACCTATCGATATGTTTTTGAAAAA
AAATATGGAGAATTGCCGAC

Downstream 100 bases:

>100_bases
CTAATGAAAAAAAGTTAGTCTGAAATCATTCATCCGGTAATCCATTTTGTGGCTTGCCGGATTATCATTTGACAATGATT
ACCTGCATACAAAAAAACCA

Product: hemin receptor precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATA
ADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGG
VIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSNGFNAPNDETISNVLA
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINAR
PQGSAEEGREQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSIL
AGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNW
DLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKG
MTTTMLLGNVFEKEYYTPQGIPQDGRNVKFFVSYQW

Sequences:

>Translated_676_residues
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATA
ADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGG
VIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSNGFNAPNDETISNVLA
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINAR
PQGSAEEGREQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSIL
AGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNW
DLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKG
MTTTMLLGNVFEKEYYTPQGIPQDGRNVKFFVSYQW
>Mature_676_residues
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATA
ADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGG
VIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSNGFNAPNDETISNVLA
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINAR
PQGSAEEGREQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSIL
AGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNW
DLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKG
MTTTMLLGNVFEKEYYTPQGIPQDGRNVKFFVSYQW

Specific function: This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family

Homologues:

Organism=Escherichia coli, GI1790405, Length=689, Percent_Identity=23.22206095791, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1786798, Length=166, Percent_Identity=32.5301204819277, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1788478, Length=151, Percent_Identity=33.112582781457, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): HMUR_YERPE (Q56989)

Other databases:

- EMBL:   U60647
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AG0035
- PIR:   T12069
- RefSeq:   NP_667880.1
- RefSeq:   NP_991832.1
- RefSeq:   YP_002345365.1
- ProteinModelPortal:   Q56989
- IntAct:   Q56989
- GeneID:   1145490
- GeneID:   1173129
- GeneID:   2765365
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0283
- KEGG:   ypk:y0543
- KEGG:   ypm:YP_0438
- HOGENOM:   HBG391236
- OMA:   DGIRQGT
- ProtClustDB:   CLSK880694
- BioCyc:   YPES187410:Y0543-MONOMER
- BioCyc:   YPES214092:YPO0283-MONOMER
- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR011276
- InterPro:   IPR010949
- Gene3D:   G3DSA:2.170.130.10
- Gene3D:   G3DSA:2.40.170.20
- TIGRFAMs:   TIGR01785
- TIGRFAMs:   TIGR01786

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec

EC number: NA

Molecular weight: Translated: 74231; Mature: 74231

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00430 TONB_DEPENDENT_REC_1; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEA
CCCCCCCCCEEECEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
PMMVTVIEGNAPTSQTAATAADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGV
CEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
RQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGGVIAYETVDAADMLQPGQNSG
HCCCCCCCCCCHHCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCHHHHCCCCCCCC
YRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSNGFNAPNDETISNVLA
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHH
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLD
CCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHCCCEEEECCCCCC
QEWLNATAQVYYSEVEINARPQGSAEEGREQTTEGVKLENRTRLFIESPASHLLTYGTET
HHHHCCEEEEEEEEEEEECCCCCCHHHHHHHHHCCCEECCCEEEEEECCHHHHHHCCCHH
YKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSILAGTRYDNYSGSSDGYADVDA
HHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCC
DKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCEEEEEECCCC
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNID
CCCCCCCCHHHHCCCCCHHHHEEECCCCEEEEEEECCCHHHHHHHHCCEEEEEEEECCCC
QAKIWGWDASMSYKTALFNWDLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFS
CEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCHHHHEEECCCCCCCCC
VGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKGMTTTMLLGNVFEKEYYTPQG
EEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHCCCCCC
IPQDGRNVKFFVSYQW
CCCCCCCEEEEEEECC
>Mature Secondary Structure
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEA
CCCCCCCCCEEECEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
PMMVTVIEGNAPTSQTAATAADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGV
CEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
RQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGGVIAYETVDAADMLQPGQNSG
HCCCCCCCCCCHHCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCHHHHCCCCCCCC
YRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSNGFNAPNDETISNVLA
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHH
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLD
CCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHCCCEEEECCCCCC
QEWLNATAQVYYSEVEINARPQGSAEEGREQTTEGVKLENRTRLFIESPASHLLTYGTET
HHHHCCEEEEEEEEEEEECCCCCCHHHHHHHHHCCCEECCCEEEEEECCHHHHHHCCCHH
YKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSILAGTRYDNYSGSSDGYADVDA
HHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCC
DKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCEEEEEECCCC
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNID
CCCCCCCCHHHHCCCCCHHHHEEECCCCEEEEEEECCCHHHHHHHHCCEEEEEEEECCCC
QAKIWGWDASMSYKTALFNWDLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFS
CEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCHHHHEEECCCCCCCCC
VGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKGMTTTMLLGNVFEKEYYTPQG
EEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHCCCCCC
IPQDGRNVKFFVSYQW
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430