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The map label for this gene is slyD

Identifier: 218927400

GI number: 218927400

Start: 210924

End: 211511

Strand: Direct

Name: slyD

Synonym: YPO0193

Alternate gene names: 218927400

Gene position: 210924-211511 (Clockwise)

Preceding gene: 218927399

Following gene: 218927402

Centisome position: 4.53

GC content: 52.55

Gene sequence:

>588_bases
ATGAAAGTAACAAAAGACTTGGTAGTCAGCCTGGCTTACCAGGTACGTACAGAAGACGGTGTTTTAGTTGATGAGTCTCC
GGTGAGCGCGCCGTTGGACTACCTGCACGGGCACGGTTCCCTGATCGCTGGTTTAGAAAACGCGCTCGAAGGCCACGAAG
CTGGTGACAGTTTTGATGTGCGTGTTAATGCCGATGAAGGTTACGGCAGCTACGATGAAAATCTGGTGCAGCGTGTACCA
AAAGACGTCTTTATGGGCGTTGACGAGCTGGAAGTGGGGATGCGTTTTCTGGCAGATACTGATCAAGGCCCAGTACCGGT
TGAGATCACTGCTGTCGAAGACGAGCACGTCGTGGTTGATGGTAACCACATGCTGGCGGGCCAGGATCTGAACTTCCACG
TTGAAGTGGTTGCTGTCCGTGAAGCAACAGAAGAAGAGTTGCAGCACGGCCATGTACATGGTGAGCATGATCATCACCAT
GAACACGGTGACGGTTGCTGCGGTGGTCACGGCCACGACGACCATGAACATGAACATGAGCATGGTAAAGGTGGTTGCGG
TAAAAGTGGCGGTTGTGGCTGTCACTAA

Upstream 100 bases:

>100_bases
GAGTAGCGTTATCTGCCGTGATTTTTTATGCGGGTGAGTACAGCGGGGCAGATTTCCGCTACAATCTGTGCCAATTTTTG
TTCCAAGGGTAGGAGATATC

Downstream 100 bases:

>100_bases
TATCTGACCCCGTCAGCAAAAAGCCAGCCTTCATCGCTGGCTTTTTGCTCTGTACGCGATCACTCATTTTCTGTGTGATA
GCCAATGATCTCGTCATAAC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MKVTKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLIAGLENALEGHEAGDSFDVRVNADEGYGSYDENLVQRVP
KDVFMGVDELEVGMRFLADTDQGPVPVEITAVEDEHVVVDGNHMLAGQDLNFHVEVVAVREATEEELQHGHVHGEHDHHH
EHGDGCCGGHGHDDHEHEHEHGKGGCGKSGGCGCH

Sequences:

>Translated_195_residues
MKVTKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLIAGLENALEGHEAGDSFDVRVNADEGYGSYDENLVQRVP
KDVFMGVDELEVGMRFLADTDQGPVPVEITAVEDEHVVVDGNHMLAGQDLNFHVEVVAVREATEEELQHGHVHGEHDHHH
EHGDGCCGGHGHDDHEHEHEHGKGGCGKSGGCGCH
>Mature_195_residues
MKVTKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLIAGLENALEGHEAGDSFDVRVNADEGYGSYDENLVQRVP
KDVFMGVDELEVGMRFLADTDQGPVPVEITAVEDEHVVVDGNHMLAGQDLNFHVEVVAVREATEEELQHGHVHGEHDHHH
EHGDGCCGGHGHDDHEHEHEHGKGGCGKSGGCGCH

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1789748, Length=147, Percent_Identity=87.7551020408163, Blast_Score=261, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SLYD_YERPE (Q7CFU4)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AD0024
- RefSeq:   NP_671268.1
- RefSeq:   NP_991590.1
- RefSeq:   YP_002345275.1
- HSSP:   O52980
- ProteinModelPortal:   Q7CFU4
- GeneID:   1148922
- GeneID:   1173037
- GeneID:   2767148
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0193
- KEGG:   ypk:y3975
- KEGG:   ypm:YP_0191
- HOGENOM:   HBG731200
- OMA:   HGHIHAH
- ProtClustDB:   PRK10737
- BioCyc:   YPES187410:Y3975-MONOMER
- GO:   GO:0005737
- InterPro:   IPR001179
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C

EC number: =5.2.1.8

Molecular weight: Translated: 21052; Mature: 21052

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLIAGLENALEGHEAGDSFDV
CCCHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCEEE
RVNADEGYGSYDENLVQRVPKDVFMGVDELEVGMRFLADTDQGPVPVEITAVEDEHVVVD
EEECCCCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEE
GNHMLAGQDLNFHVEVVAVREATEEELQHGHVHGEHDHHHEHGDGCCGGHGHDDHEHEHE
CCEEEECCCCCEEEEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HGKGGCGKSGGCGCH
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVTKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLIAGLENALEGHEAGDSFDV
CCCHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCEEE
RVNADEGYGSYDENLVQRVPKDVFMGVDELEVGMRFLADTDQGPVPVEITAVEDEHVVVD
EEECCCCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEE
GNHMLAGQDLNFHVEVVAVREATEEELQHGHVHGEHDHHHEHGDGCCGGHGHDDHEHEHE
CCEEEECCCCCEEEEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HGKGGCGKSGGCGCH
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430