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The map label for this gene is acuC [H]

Identifier: 15922638

GI number: 15922638

Start: 2311880

End: 2312968

Strand: Direct

Name: acuC [H]

Synonym: ST2305

Alternate gene names: 15922638

Gene position: 2311880-2312968 (Clockwise)

Preceding gene: 15922635

Following gene: 15922640

Centisome position: 85.79

GC content: 34.34

Gene sequence:

>1089_bases
GTGCATTTATATAGTTTTTCAACGAGTATAATATGTGTGCATAAGACAGCGTTTGTATGGGATGATAGATACTTAAACTA
TTCCTTTCCAGGTAATCATCCTTTTAAATCTCTTAGAGAAGCAATGACTAAGAAACTCTTAGAAGAAAGAGGAGCATTTC
ACGAAATAGATATAGTACCTCCTAAGGTAATTAGCGAAGAATTATTATCTCTTATACATACAAAAGAATATATAGAATTT
ATTAAGAGAAAGAGCGAAGAGGGTAGTGGATTATTAGATGAAGGAGACACTCCAGCATTTAAAGGAATTTTTGAAGCTGC
TCTTATTAGAGTGAGTGGTACTGTTACAGCTGTAGAGCTTCTACAATCTTATGATCATACTATAAATATTGGAGGCGGAT
TTCATCATGCTAAAAGATCCCAAGCGTCTGGTTTTTGTGTGTTTAATGATGTAGCGTTAGCTATAAAGTTGGCAGAGAGA
AGTTTCAAAAAAATTGCATTAGTGGATATTGATGGTCATCATGGCGATGGAACTCAATACTTGCTTTATGATGACCCAAA
AGTTTTGAAAGTCTCTCTTCATATGTTTCATCCAAGATTTTTCCCTGGTACTGGAGATGAATATGAGATAGGTTCTGGAG
AGGGAAAAGGTATGACTATTAATATTCCGTTGCCTCCAGGGACTGGAGATGATATGTATCTTTACGCGTTTAATGAAATA
GTTGTTCCAAAGATTAAGGAGTTTAAGCCAGATTTGATATTTCTTCTTAATGGTGGAGATTCTTACTACGAAGATCCTCT
TGTAGAGCTTAAACTTTCTACAAAAGGTTATCTTGAAGTAGTAAGGACTGTTCACTCGCTTGCCCATCAATTTGCTAATG
GTAAGTTAGTTATGACAGGTGGTGGAGGATATAATTATGAAGCTACAGCAAGAATATGGGCTTTATCAATAGCAGAAATA
GCTGGATTGGATTTTACTGAATTTGAAACTTTAGAGGATTGTTGTTTAATAGCTTCTAGTGAATTTGTCAAGAAAAGAGT
ATTAGAAATAGTAGATAAATTAAAGAAAATACATGGTCTAAGTAACTAG

Upstream 100 bases:

>100_bases
TGCATTCTGGAAATGACTTCCCTTACTCTATCATTATATGATGCAACTACCTTAGGCTCTTCCAAAAGCTCTTTTGGTAT
CATTAAGGAAAAATCCAGAT

Downstream 100 bases:

>100_bases
GACTAATGAAGCTGCTTTCCTTGCTTTTTCCTTTGCTTCCTCTACTGTATTACCAGTAGCTAATACCACTCCCATTCTTC
TTTTATAATACGTTGATGGT

Product: acetoin utilization protein AcuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MHLYSFSTSIICVHKTAFVWDDRYLNYSFPGNHPFKSLREAMTKKLLEERGAFHEIDIVPPKVISEELLSLIHTKEYIEF
IKRKSEEGSGLLDEGDTPAFKGIFEAALIRVSGTVTAVELLQSYDHTINIGGGFHHAKRSQASGFCVFNDVALAIKLAER
SFKKIALVDIDGHHGDGTQYLLYDDPKVLKVSLHMFHPRFFPGTGDEYEIGSGEGKGMTINIPLPPGTGDDMYLYAFNEI
VVPKIKEFKPDLIFLLNGGDSYYEDPLVELKLSTKGYLEVVRTVHSLAHQFANGKLVMTGGGGYNYEATARIWALSIAEI
AGLDFTEFETLEDCCLIASSEFVKKRVLEIVDKLKKIHGLSN

Sequences:

>Translated_362_residues
MHLYSFSTSIICVHKTAFVWDDRYLNYSFPGNHPFKSLREAMTKKLLEERGAFHEIDIVPPKVISEELLSLIHTKEYIEF
IKRKSEEGSGLLDEGDTPAFKGIFEAALIRVSGTVTAVELLQSYDHTINIGGGFHHAKRSQASGFCVFNDVALAIKLAER
SFKKIALVDIDGHHGDGTQYLLYDDPKVLKVSLHMFHPRFFPGTGDEYEIGSGEGKGMTINIPLPPGTGDDMYLYAFNEI
VVPKIKEFKPDLIFLLNGGDSYYEDPLVELKLSTKGYLEVVRTVHSLAHQFANGKLVMTGGGGYNYEATARIWALSIAEI
AGLDFTEFETLEDCCLIASSEFVKKRVLEIVDKLKKIHGLSN
>Mature_362_residues
MHLYSFSTSIICVHKTAFVWDDRYLNYSFPGNHPFKSLREAMTKKLLEERGAFHEIDIVPPKVISEELLSLIHTKEYIEF
IKRKSEEGSGLLDEGDTPAFKGIFEAALIRVSGTVTAVELLQSYDHTINIGGGFHHAKRSQASGFCVFNDVALAIKLAER
SFKKIALVDIDGHHGDGTQYLLYDDPKVLKVSLHMFHPRFFPGTGDEYEIGSGEGKGMTINIPLPPGTGDDMYLYAFNEI
VVPKIKEFKPDLIFLLNGGDSYYEDPLVELKLSTKGYLEVVRTVHSLAHQFANGKLVMTGGGGYNYEATARIWALSIAEI
AGLDFTEFETLEDCCLIASSEFVKKRVLEIVDKLKKIHGLSN

Specific function: Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128860, Length=361, Percent_Identity=32.1329639889197, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI8923769, Length=293, Percent_Identity=34.8122866894198, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI13128862, Length=309, Percent_Identity=32.3624595469256, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI293336691, Length=361, Percent_Identity=32.409972299169, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI262073092, Length=204, Percent_Identity=38.7254901960784, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI20070354, Length=326, Percent_Identity=29.7546012269939, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI262073088, Length=238, Percent_Identity=31.5126050420168, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI13128864, Length=312, Percent_Identity=31.7307692307692, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI30795202, Length=232, Percent_Identity=36.6379310344828, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI30795204, Length=232, Percent_Identity=36.6379310344828, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI17158039, Length=208, Percent_Identity=38.4615384615385, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI153085395, Length=233, Percent_Identity=36.0515021459227, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI169234807, Length=197, Percent_Identity=37.5634517766497, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI148539870, Length=197, Percent_Identity=37.5634517766497, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI62750349, Length=233, Percent_Identity=33.9055793991416, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI62750347, Length=233, Percent_Identity=33.9055793991416, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI226529806, Length=249, Percent_Identity=32.1285140562249, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI209862883, Length=297, Percent_Identity=27.9461279461279, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI217272877, Length=325, Percent_Identity=27.3846153846154, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI262072965, Length=149, Percent_Identity=26.8456375838926, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17508561, Length=314, Percent_Identity=33.1210191082803, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17561978, Length=310, Percent_Identity=34.8387096774194, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17534739, Length=302, Percent_Identity=33.112582781457, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=31.3915857605178, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=31.3915857605178, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193206283, Length=294, Percent_Identity=32.312925170068, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193209491, Length=355, Percent_Identity=29.0140845070423, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25154020, Length=277, Percent_Identity=29.6028880866426, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537347, Length=258, Percent_Identity=27.5193798449612, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193207430, Length=303, Percent_Identity=26.4026402640264, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25154022, Length=277, Percent_Identity=28.8808664259928, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321244, Length=311, Percent_Identity=32.475884244373, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6323999, Length=311, Percent_Identity=31.8327974276527, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324307, Length=325, Percent_Identity=32, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325325, Length=224, Percent_Identity=31.25, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24657891, Length=361, Percent_Identity=31.5789473684211, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24644244, Length=315, Percent_Identity=31.1111111111111, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642142, Length=331, Percent_Identity=28.7009063444109, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24642146, Length=331, Percent_Identity=28.7009063444109, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24642144, Length=331, Percent_Identity=28.7009063444109, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360899, Length=331, Percent_Identity=28.7009063444109, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24641720, Length=184, Percent_Identity=38.0434782608696, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281360801, Length=184, Percent_Identity=38.0434782608696, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281360799, Length=184, Percent_Identity=38.0434782608696, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24649807, Length=300, Percent_Identity=26.3333333333333, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003085
- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 40435; Mature: 40435

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLYSFSTSIICVHKTAFVWDDRYLNYSFPGNHPFKSLREAMTKKLLEERGAFHEIDIVP
CEEEEECCEEEEEEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCC
PKVISEELLSLIHTKEYIEFIKRKSEEGSGLLDEGDTPAFKGIFEAALIRVSGTVTAVEL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
LQSYDHTINIGGGFHHAKRSQASGFCVFNDVALAIKLAERSFKKIALVDIDGHHGDGTQY
HHHCCCEEEECCCCCHHHHCCCCCEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCEEE
LLYDDPKVLKVSLHMFHPRFFPGTGDEYEIGSGEGKGMTINIPLPPGTGDDMYLYAFNEI
EEECCCCEEEEEEEEECCEECCCCCCCEECCCCCCCEEEEEEECCCCCCCCEEEEEECCE
VVPKIKEFKPDLIFLLNGGDSYYEDPLVELKLSTKGYLEVVRTVHSLAHQFANGKLVMTG
ECCCHHCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEC
GGGYNYEATARIWALSIAEIAGLDFTEFETLEDCCLIASSEFVKKRVLEIVDKLKKIHGL
CCCCCCCHHHEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SN
CC
>Mature Secondary Structure
MHLYSFSTSIICVHKTAFVWDDRYLNYSFPGNHPFKSLREAMTKKLLEERGAFHEIDIVP
CEEEEECCEEEEEEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCC
PKVISEELLSLIHTKEYIEFIKRKSEEGSGLLDEGDTPAFKGIFEAALIRVSGTVTAVEL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
LQSYDHTINIGGGFHHAKRSQASGFCVFNDVALAIKLAERSFKKIALVDIDGHHGDGTQY
HHHCCCEEEECCCCCHHHHCCCCCEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCEEE
LLYDDPKVLKVSLHMFHPRFFPGTGDEYEIGSGEGKGMTINIPLPPGTGDDMYLYAFNEI
EEECCCCEEEEEEEEECCEECCCCCCCEECCCCCCCEEEEEEECCCCCCCCEEEEEECCE
VVPKIKEFKPDLIFLLNGGDSYYEDPLVELKLSTKGYLEVVRTVHSLAHQFANGKLVMTG
ECCCHHCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEC
GGGYNYEATARIWALSIAEIAGLDFTEFETLEDCCLIASSEFVKKRVLEIVDKLKKIHGL
CCCCCCCHHHEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]