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The map label for this gene is thyX

Identifier: 15922543

GI number: 15922543

Start: 2223156

End: 2223929

Strand: Direct

Name: thyX

Synonym: ST2215

Alternate gene names: 15922543

Gene position: 2223156-2223929 (Clockwise)

Preceding gene: 15922542

Following gene: 15922544

Centisome position: 82.5

GC content: 35.4

Gene sequence:

>774_bases
ATGAATGTTAAACTTGTTTCTTATACTCGTGATGGAGAAAAAGTTGTAGCAATAGCTTCTAAGATGAGTAGAAGTAGAAA
GGGTTGGGATTATCACGAAAAAACAATGACTGATGAAGAAATTGAGGTTTGGATCAGAGATGCAATTCTGCACGGGTACT
GGAGTGTTCTTGAGCATAGTATTTACACTTTTTCTATAGAGGGAATTAGCAGGGTAGCATCTCACCAGTTAGTTAGACAT
AGGGTAGCATCTTACACTCAAATGAGTCACAGATTTGCTAAGCCCATAGATGAGTACTACAAGCCGATAACCCCGCCGTC
AATAGAAAAGAGAGCTAAAGAAATTATAGAAAAAGCATATCAAGAAGCCTATGAAAACTATTTCAAACTCCTTCAAGATG
GTGTACCAGAAGAGGATGCTAGATATGTTTTACCTAATGGTGTAAATACTAACATAGTCGTCACTATGAATGCTAGAGAA
CTCTATAATTTCTTTGCACTTAGACTCTGCAGTAGAGCCCAGTGGGAAATTAGAGCTATTGCATGGAAGATGTTGGAAGA
AGTAAAAAAAGTTCACCCTAGACTCTTCCGTTATGTAGGTCCTAATTGTATAATTCATGAAAACTTCATTAGAAACGAAC
CTATTACTTTAGATGAAGTTCTCCAAAAGGACAATATAGAGTTTATATCTCAACGTTGTATTGAAGGAGTTATGAGGGAT
GGAATTTTAAAATGTATAAGAAATTCTAAACATGTTTTGGAATATTTAAAGTAA

Upstream 100 bases:

>100_bases
CAACTTACTCGATTGGTAGAAAAGTTAAGTGGAGTACTATCTTAAGGTAATATTAAATGAAAAGTTTTTTACTTGTTTTT
GAGAAAGCTTAATATTTAAA

Downstream 100 bases:

>100_bases
ATTCATTTTTTAAAATATCACATATACAAATGCTCTAAATTGATTTTTGCTTTTAAATTACCTTTTTCGAACAATTAGTA
GAAAAATATTTTAGGTATTC

Product: hypothetical protein

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MNVKLVSYTRDGEKVVAIASKMSRSRKGWDYHEKTMTDEEIEVWIRDAILHGYWSVLEHSIYTFSIEGISRVASHQLVRH
RVASYTQMSHRFAKPIDEYYKPITPPSIEKRAKEIIEKAYQEAYENYFKLLQDGVPEEDARYVLPNGVNTNIVVTMNARE
LYNFFALRLCSRAQWEIRAIAWKMLEEVKKVHPRLFRYVGPNCIIHENFIRNEPITLDEVLQKDNIEFISQRCIEGVMRD
GILKCIRNSKHVLEYLK

Sequences:

>Translated_257_residues
MNVKLVSYTRDGEKVVAIASKMSRSRKGWDYHEKTMTDEEIEVWIRDAILHGYWSVLEHSIYTFSIEGISRVASHQLVRH
RVASYTQMSHRFAKPIDEYYKPITPPSIEKRAKEIIEKAYQEAYENYFKLLQDGVPEEDARYVLPNGVNTNIVVTMNARE
LYNFFALRLCSRAQWEIRAIAWKMLEEVKKVHPRLFRYVGPNCIIHENFIRNEPITLDEVLQKDNIEFISQRCIEGVMRD
GILKCIRNSKHVLEYLK
>Mature_257_residues
MNVKLVSYTRDGEKVVAIASKMSRSRKGWDYHEKTMTDEEIEVWIRDAILHGYWSVLEHSIYTFSIEGISRVASHQLVRH
RVASYTQMSHRFAKPIDEYYKPITPPSIEKRAKEIIEKAYQEAYENYFKLLQDGVPEEDARYVLPNGVNTNIVVTMNARE
LYNFFALRLCSRAQWEIRAIAWKMLEEVKKVHPRLFRYVGPNCIIHENFIRNEPITLDEVLQKDNIEFISQRCIEGVMRD
GILKCIRNSKHVLEYLK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_SULTO (Q96YF6)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_378212.1
- ProteinModelPortal:   Q96YF6
- SMR:   Q96YF6
- GeneID:   1460292
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST2215
- NMPDR:   fig|273063.1.peg.2380
- HOGENOM:   HBG458114
- OMA:   GHGSPLE
- ProtClustDB:   CLSK2484412
- BioCyc:   STOK273063:ST2215-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 30344; Mature: 30344

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKLVSYTRDGEKVVAIASKMSRSRKGWDYHEKTMTDEEIEVWIRDAILHGYWSVLEHS
CCCEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
IYTFSIEGISRVASHQLVRHRVASYTQMSHRFAKPIDEYYKPITPPSIEKRAKEIIEKAY
HHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QEAYENYFKLLQDGVPEEDARYVLPNGVNTNIVVTMNARELYNFFALRLCSRAQWEIRAI
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHH
AWKMLEEVKKVHPRLFRYVGPNCIIHENFIRNEPITLDEVLQKDNIEFISQRCIEGVMRD
HHHHHHHHHHHHHHHHHHHCCCCEEECHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHH
GILKCIRNSKHVLEYLK
HHHHHHHCCHHHHHHHC
>Mature Secondary Structure
MNVKLVSYTRDGEKVVAIASKMSRSRKGWDYHEKTMTDEEIEVWIRDAILHGYWSVLEHS
CCCEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
IYTFSIEGISRVASHQLVRHRVASYTQMSHRFAKPIDEYYKPITPPSIEKRAKEIIEKAY
HHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QEAYENYFKLLQDGVPEEDARYVLPNGVNTNIVVTMNARELYNFFALRLCSRAQWEIRAI
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHH
AWKMLEEVKKVHPRLFRYVGPNCIIHENFIRNEPITLDEVLQKDNIEFISQRCIEGVMRD
HHHHHHHHHHHHHHHHHHHCCCCEEECHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHH
GILKCIRNSKHVLEYLK
HHHHHHHCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479