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The map label for this gene is exoA [H]

Identifier: 15922225

GI number: 15922225

Start: 1913101

End: 1913826

Strand: Direct

Name: exoA [H]

Synonym: ST1910

Alternate gene names: 15922225

Gene position: 1913101-1913826 (Clockwise)

Preceding gene: 15922224

Following gene: 15922230

Centisome position: 70.99

GC content: 31.54

Gene sequence:

>726_bases
ATGAAAATAGTTAGTTGGAATGTCAATGGGCTTAAGGCTATAACTAGAAAAGGAGCTTTAGAATCTGTATTAAATTACGA
TGCTATTTTATTACAAGAGATTCGTAGTAGTGATTTACCCTTAGATTTGTTAATGAGCGGATTTAACATTGCTTCTTTTC
CAGCTAAGAAGAAGGGGTATAGCGGTGTTATGACATTAACTAGAGAAAAACCTAAAAGTATAATAAAAGGCTTAAACGTT
AAGGAATTTGATGAAGAAGGAAGAACTGTTACAGTTGAGTTGGAAAAATTTTATCTAATCAATGCTTATTTTCCTAGAGC
AGGAGATGGGCTTAGTAGATTAGATTTTAAAATATCTTTTGATAATAAAATTGAAGAATTTATGGACCAGCTAAGAAGAA
CAAAACCAGTTATTATTTGCGGTGATTTTAATGCTGTGGTGGAAAGAAGGGATTCTTCTTTTTGGGATGAAAATGAACCG
GGTCTTTCGCCTAAAGAAAGAGAATGGATGAACCACATCTTGAAAAAAGGATATATTGATGCTTATAGGTTTATTAACCC
TACAAAAATTGAATATAGTTGGAGGAGCTATAGATTTAAATGGAAAGCTATGAGAATAGATTATTGTTTAGTTTCTGAAG
AATTAAAGGATAAAATTAGGGATTGCAAAATATTAAATGTATCTGGCTCTGATCATTATCCTATTCTTCTTGAGATAGAA
GTCTGA

Upstream 100 bases:

>100_bases
ACTGGAGCCTTCATGGGACAAAAGGGTTCTTATGTGAGATTTGTTGATGAAGCTATTAGAAAACTTTTAGGTGTAGGTAT
AAGAGTTATAGCGAAGGAGA

Downstream 100 bases:

>100_bases
TATATATTTTGTAAAATGGCAGCTAATTGTGTTATTGACGCTTTAAAATTCTGGTAATCATTTTGTATCTTATAGGAGAA
AGCTTGTTGATATAGCAAAT

Product: exodeoxyribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKIVSWNVNGLKAITRKGALESVLNYDAILLQEIRSSDLPLDLLMSGFNIASFPAKKKGYSGVMTLTREKPKSIIKGLNV
KEFDEEGRTVTVELEKFYLINAYFPRAGDGLSRLDFKISFDNKIEEFMDQLRRTKPVIICGDFNAVVERRDSSFWDENEP
GLSPKEREWMNHILKKGYIDAYRFINPTKIEYSWRSYRFKWKAMRIDYCLVSEELKDKIRDCKILNVSGSDHYPILLEIE
V

Sequences:

>Translated_241_residues
MKIVSWNVNGLKAITRKGALESVLNYDAILLQEIRSSDLPLDLLMSGFNIASFPAKKKGYSGVMTLTREKPKSIIKGLNV
KEFDEEGRTVTVELEKFYLINAYFPRAGDGLSRLDFKISFDNKIEEFMDQLRRTKPVIICGDFNAVVERRDSSFWDENEP
GLSPKEREWMNHILKKGYIDAYRFINPTKIEYSWRSYRFKWKAMRIDYCLVSEELKDKIRDCKILNVSGSDHYPILLEIE
V
>Mature_241_residues
MKIVSWNVNGLKAITRKGALESVLNYDAILLQEIRSSDLPLDLLMSGFNIASFPAKKKGYSGVMTLTREKPKSIIKGLNV
KEFDEEGRTVTVELEKFYLINAYFPRAGDGLSRLDFKISFDNKIEEFMDQLRRTKPVIICGDFNAVVERRDSSFWDENEP
GLSPKEREWMNHILKKGYIDAYRFINPTKIEYSWRSYRFKWKAMRIDYCLVSEELKDKIRDCKILNVSGSDHYPILLEIE
V

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=253, Percent_Identity=35.5731225296443, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI18375503, Length=253, Percent_Identity=35.5731225296443, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI18375501, Length=253, Percent_Identity=35.5731225296443, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1788046, Length=266, Percent_Identity=30.8270676691729, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71989536, Length=253, Percent_Identity=32.0158102766798, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71989539, Length=143, Percent_Identity=32.8671328671329, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221330655, Length=252, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136678, Length=252, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=6e-27,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 28084; Mature: 28084

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVSWNVNGLKAITRKGALESVLNYDAILLQEIRSSDLPLDLLMSGFNIASFPAKKKGY
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCC
SGVMTLTREKPKSIIKGLNVKEFDEEGRTVTVELEKFYLINAYFPRAGDGLSRLDFKISF
CCEEEEECHHHHHHHCCCCCCHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCCEEEEEEC
DNKIEEFMDQLRRTKPVIICGDFNAVVERRDSSFWDENEPGLSPKEREWMNHILKKGYID
CHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHH
AYRFINPTKIEYSWRSYRFKWKAMRIDYCLVSEELKDKIRDCKILNVSGSDHYPILLEIE
HHHCCCCCEEEEEHHCEEEEEEEEEEEHEEHHHHHHHHHHCCEEEEECCCCCCCEEEEEE
V
C
>Mature Secondary Structure
MKIVSWNVNGLKAITRKGALESVLNYDAILLQEIRSSDLPLDLLMSGFNIASFPAKKKGY
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCC
SGVMTLTREKPKSIIKGLNVKEFDEEGRTVTVELEKFYLINAYFPRAGDGLSRLDFKISF
CCEEEEECHHHHHHHCCCCCCHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCCEEEEEEC
DNKIEEFMDQLRRTKPVIICGDFNAVVERRDSSFWDENEPGLSPKEREWMNHILKKGYID
CHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHH
AYRFINPTKIEYSWRSYRFKWKAMRIDYCLVSEELKDKIRDCKILNVSGSDHYPILLEIE
HHHCCCCCEEEEEHHCEEEEEEEEEEEHEEHHHHHHHHHHCCEEEEECCCCCCCEEEEEE
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]