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The map label for this gene is acsA [H]

Identifier: 15922110

GI number: 15922110

Start: 1813461

End: 1815290

Strand: Reverse

Name: acsA [H]

Synonym: ST1796

Alternate gene names: 15922110

Gene position: 1815290-1813461 (Counterclockwise)

Preceding gene: 15922111

Following gene: 15922105

Centisome position: 67.36

GC content: 35.74

Gene sequence:

>1830_bases
ATGAGTTGGTTACCTACAAAGGATTGGATTGAGGAAAGTAATGTTTATTCTTTTATGTTAGAAAACGATATTTCTAAGTT
ATCACATTTTATTTCTTATACTTATGAAAAGCCTGAGGAATTTTGGGACAAATTTGTCAAAAGGATAGGATTAAAGTTTT
ATTCTAAATATGATAAAGTCTTAGATTTATCTCAAGGAAAGCCGTGGGCAAAGTGGTTCATTAATGGAAAATTAAATATT
GGGGATCAAATTCCAGATTCTTCAGAAGTTTTCATAAAATGGATGGATGAGAAGGAGAATTCAAGGACAATAACCTATTC
TGATGTACTTCAACAAGCTAAGGCAGTTTCTTCCTGGTTAAAGAAATTCGGATTAAAGAAAGGTGATACTGTAGGAATTT
ATATGCCAATGATACCAGAAATAGTTCCAGTATTTCTAGGAATAGCAAGAGCTGGAATGATTGCAGTTCCTTTGTTTTCG
GGATTTGGTAAAGAGCCAATAAGAGTTAGAGCAGAAGATAGTGGAATGAAAGTTATTTTTACTACAGATATGACTATAAG
AAAAGGAAAAGAGATAAATTCACTTGAAAATTTAGAGGGGCTTACGCTAACTAAAGTAGTTGTGGAAAGAGGCGGGAAAA
AGGATAAAGATTCTATTAGTTATTCAGAAGTATTATCTACTGCTGGCGATGGGTTAGAAGTAACAGATACTGAAGACCCC
TTCATGATAATTTATACTAGTGGAACTACTGGAAAACCTAAAGGGTGCGTACATACTCACGACGGTTTCCCAATAAAGGC
TTCTGCAGATGTTTATTTCCAATTTGATTTGAAGAAAAGAGAGACACTCATGTGGGTTACTGATTTGGGCTGGATGATGG
GTCCCTGGATGATATTGTCTGCCTTACTGTTGAGAGGGAAAATTGGGATGATTGAAGGTTATACTGCTTACTCCTTGTTG
AGTAAATTTATCGAAGATATGAAGGTTGATATCCTGGGTTTATCTGCAAGTTTAATTAGAGCCTTTAGAAGTGAAGTTGA
AAAAGGTAAGTTAGACGTTAGAATTGTTGGGAATACTGGTGAGCCAATTGATTATGAAAGTTGGAAGTGGCTATATGAGG
CTGTTAAAGGTCCAATAATTAACTACTCTGGAGGTACTGAAATTTCTGGAGGCATATTAGGAAATTATGTAATAAATGAA
ATTAAACCTACCGCTTTCAACGGCTTCTCTCCTGGTATTCATGCTGATGTATTTGATGAAAATGGAAAACATGCACCAGC
AAATGTTGAGGGAGAGTTAGTTGTATTAAGTGTTTGGCCTGGGATGGCAAGAGGCTTTTGGAAGGACAAAGAAAGATATC
TTAACACTTATTGGAGTAGGTGGGAGGGAGTATGGGTTCACGGTGATTTAGCCTATTATGACGAAGATGGATTTTATTAC
ATTGTTGGAAGAAGTGATGATACTATTAAGGTTGCAGGTAAAAGGGTGGGACCAGCAGAGGTTGAGCAAATAATTAACTC
TTACGAAGGTGTAGTTGAAAGTGCATGTGTAGGAGTCCCAGATCCTATGAAAGGAGAAGAAATTTTATGCTTTGCTGTAA
CTAATAAGGAGATCAAGAAAGATGAATTATTAAATTATACACAGAGAATGTTAGGAAAAGCATTAGCACCAAAGGATATA
ATATTTGTTAAGGAATTGCCAAAGACTAGGAATGCTAAGATTATGAGGAGGTTAATAAGAGCAGTAGTATTAGGGAAACC
TACTGGAGATATAAGTGCTCTTGAGAATCCATCAGCTTTAGAGGAAATTAAAAAAGCCCTAACTAGTTAA

Upstream 100 bases:

>100_bases
GTACGCATGGTGGTTTACTAGCTTACATTGAAGGTGAGGCAGATATTGGAAAAGAAGTTGAAATACTTGAATACAAAATA
CCATTAATAGTGAGGGTTAA

Downstream 100 bases:

>100_bases
CCATAATTGTATGATATTCCGCCTTCAGGAAATCTAAATTTTATTGCGCCAAAGGGACAAATAACTAATGCTCCCCCACA
TTCCAAACATCTTTCATAGT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSWLPTKDWIEESNVYSFMLENDISKLSHFISYTYEKPEEFWDKFVKRIGLKFYSKYDKVLDLSQGKPWAKWFINGKLNI
GDQIPDSSEVFIKWMDEKENSRTITYSDVLQQAKAVSSWLKKFGLKKGDTVGIYMPMIPEIVPVFLGIARAGMIAVPLFS
GFGKEPIRVRAEDSGMKVIFTTDMTIRKGKEINSLENLEGLTLTKVVVERGGKKDKDSISYSEVLSTAGDGLEVTDTEDP
FMIIYTSGTTGKPKGCVHTHDGFPIKASADVYFQFDLKKRETLMWVTDLGWMMGPWMILSALLLRGKIGMIEGYTAYSLL
SKFIEDMKVDILGLSASLIRAFRSEVEKGKLDVRIVGNTGEPIDYESWKWLYEAVKGPIINYSGGTEISGGILGNYVINE
IKPTAFNGFSPGIHADVFDENGKHAPANVEGELVVLSVWPGMARGFWKDKERYLNTYWSRWEGVWVHGDLAYYDEDGFYY
IVGRSDDTIKVAGKRVGPAEVEQIINSYEGVVESACVGVPDPMKGEEILCFAVTNKEIKKDELLNYTQRMLGKALAPKDI
IFVKELPKTRNAKIMRRLIRAVVLGKPTGDISALENPSALEEIKKALTS

Sequences:

>Translated_609_residues
MSWLPTKDWIEESNVYSFMLENDISKLSHFISYTYEKPEEFWDKFVKRIGLKFYSKYDKVLDLSQGKPWAKWFINGKLNI
GDQIPDSSEVFIKWMDEKENSRTITYSDVLQQAKAVSSWLKKFGLKKGDTVGIYMPMIPEIVPVFLGIARAGMIAVPLFS
GFGKEPIRVRAEDSGMKVIFTTDMTIRKGKEINSLENLEGLTLTKVVVERGGKKDKDSISYSEVLSTAGDGLEVTDTEDP
FMIIYTSGTTGKPKGCVHTHDGFPIKASADVYFQFDLKKRETLMWVTDLGWMMGPWMILSALLLRGKIGMIEGYTAYSLL
SKFIEDMKVDILGLSASLIRAFRSEVEKGKLDVRIVGNTGEPIDYESWKWLYEAVKGPIINYSGGTEISGGILGNYVINE
IKPTAFNGFSPGIHADVFDENGKHAPANVEGELVVLSVWPGMARGFWKDKERYLNTYWSRWEGVWVHGDLAYYDEDGFYY
IVGRSDDTIKVAGKRVGPAEVEQIINSYEGVVESACVGVPDPMKGEEILCFAVTNKEIKKDELLNYTQRMLGKALAPKDI
IFVKELPKTRNAKIMRRLIRAVVLGKPTGDISALENPSALEEIKKALTS
>Mature_608_residues
SWLPTKDWIEESNVYSFMLENDISKLSHFISYTYEKPEEFWDKFVKRIGLKFYSKYDKVLDLSQGKPWAKWFINGKLNIG
DQIPDSSEVFIKWMDEKENSRTITYSDVLQQAKAVSSWLKKFGLKKGDTVGIYMPMIPEIVPVFLGIARAGMIAVPLFSG
FGKEPIRVRAEDSGMKVIFTTDMTIRKGKEINSLENLEGLTLTKVVVERGGKKDKDSISYSEVLSTAGDGLEVTDTEDPF
MIIYTSGTTGKPKGCVHTHDGFPIKASADVYFQFDLKKRETLMWVTDLGWMMGPWMILSALLLRGKIGMIEGYTAYSLLS
KFIEDMKVDILGLSASLIRAFRSEVEKGKLDVRIVGNTGEPIDYESWKWLYEAVKGPIINYSGGTEISGGILGNYVINEI
KPTAFNGFSPGIHADVFDENGKHAPANVEGELVVLSVWPGMARGFWKDKERYLNTYWSRWEGVWVHGDLAYYDEDGFYYI
VGRSDDTIKVAGKRVGPAEVEQIINSYEGVVESACVGVPDPMKGEEILCFAVTNKEIKKDELLNYTQRMLGKALAPKDII
FVKELPKTRNAKIMRRLIRAVVLGKPTGDISALENPSALEEIKKALTS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=674, Percent_Identity=29.8219584569733, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI28416953, Length=629, Percent_Identity=29.4117647058824, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI253970489, Length=687, Percent_Identity=29.1120815138282, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI13375727, Length=625, Percent_Identity=28.96, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI31982927, Length=612, Percent_Identity=25.6535947712418, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI42544132, Length=510, Percent_Identity=26.4705882352941, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI115511026, Length=581, Percent_Identity=27.5387263339071, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI38505220, Length=523, Percent_Identity=25.6214149139579, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI58082049, Length=538, Percent_Identity=26.9516728624535, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI122937307, Length=534, Percent_Identity=27.1535580524345, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI157311624, Length=539, Percent_Identity=26.7161410018553, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI157311622, Length=539, Percent_Identity=26.7161410018553, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI156151445, Length=545, Percent_Identity=23.6697247706422, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI187761345, Length=387, Percent_Identity=24.5478036175711, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI187761343, Length=387, Percent_Identity=24.5478036175711, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI42544134, Length=342, Percent_Identity=23.0994152046784, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1790505, Length=610, Percent_Identity=30.983606557377, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI1786529, Length=629, Percent_Identity=28.1399046104928, Blast_Score=233, Evalue=4e-62,
Organism=Escherichia coli, GI145693145, Length=524, Percent_Identity=22.1374045801527, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI221142682, Length=501, Percent_Identity=22.1556886227545, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788107, Length=178, Percent_Identity=33.7078651685393, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786801, Length=438, Percent_Identity=20.3196347031963, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1789201, Length=478, Percent_Identity=24.2677824267782, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71982997, Length=558, Percent_Identity=30.1075268817204, Blast_Score=221, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI71983001, Length=558, Percent_Identity=30.1075268817204, Blast_Score=221, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17569507, Length=623, Percent_Identity=24.5585874799358, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17559526, Length=515, Percent_Identity=24.6601941747573, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531443, Length=490, Percent_Identity=25.7142857142857, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=535, Percent_Identity=21.3084112149533, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=553, Percent_Identity=23.6889692585895, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=498, Percent_Identity=22.6907630522088, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=487, Percent_Identity=20.1232032854209, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=362, Percent_Identity=25.1381215469613, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=493, Percent_Identity=21.9066937119675, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=658, Percent_Identity=31.9148936170213, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319264, Length=625, Percent_Identity=31.52, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6319699, Length=480, Percent_Identity=21.875, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667955, Length=633, Percent_Identity=29.2259083728278, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI62472339, Length=549, Percent_Identity=30.7832422586521, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24667959, Length=515, Percent_Identity=30.0970873786408, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI21355225, Length=625, Percent_Identity=25.44, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21355181, Length=486, Percent_Identity=26.1316872427983, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18859661, Length=503, Percent_Identity=23.6580516898608, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648260, Length=566, Percent_Identity=23.4982332155477, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581924, Length=549, Percent_Identity=21.4936247723133, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24656500, Length=495, Percent_Identity=22.2222222222222, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20130357, Length=508, Percent_Identity=25.3937007874016, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653035, Length=515, Percent_Identity=24.2718446601942, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356947, Length=351, Percent_Identity=25.3561253561254, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358303, Length=501, Percent_Identity=21.5568862275449, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281365686, Length=494, Percent_Identity=20.8502024291498, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 68503; Mature: 68371

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWLPTKDWIEESNVYSFMLENDISKLSHFISYTYEKPEEFWDKFVKRIGLKFYSKYDKV
CCCCCCHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LDLSQGKPWAKWFINGKLNIGDQIPDSSEVFIKWMDEKENSRTITYSDVLQQAKAVSSWL
EECCCCCCCEEEEEECEEECCCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHH
KKFGLKKGDTVGIYMPMIPEIVPVFLGIARAGMIAVPLFSGFGKEPIRVRAEDSGMKVIF
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEHHHHCCCCCCEEEEECCCCCEEEE
TTDMTIRKGKEINSLENLEGLTLTKVVVERGGKKDKDSISYSEVLSTAGDGLEVTDTEDP
EECCEEECCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECCCCC
FMIIYTSGTTGKPKGCVHTHDGFPIKASADVYFQFDLKKRETLMWVTDLGWMMGPWMILS
EEEEEECCCCCCCCCCEECCCCCCEEECCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHH
ALLLRGKIGMIEGYTAYSLLSKFIEDMKVDILGLSASLIRAFRSEVEKGKLDVRIVGNTG
HHHHCCCCCEECCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCC
EPIDYESWKWLYEAVKGPIINYSGGTEISGGILGNYVINEIKPTAFNGFSPGIHADVFDE
CCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECC
NGKHAPANVEGELVVLSVWPGMARGFWKDKERYLNTYWSRWEGVWVHGDLAYYDEDGFYY
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEECCCEEE
IVGRSDDTIKVAGKRVGPAEVEQIINSYEGVVESACVGVPDPMKGEEILCFAVTNKEIKK
EEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCH
DELLNYTQRMLGKALAPKDIIFVKELPKTRNAKIMRRLIRAVVLGKPTGDISALENPSAL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
EEIKKALTS
HHHHHHHCC
>Mature Secondary Structure 
SWLPTKDWIEESNVYSFMLENDISKLSHFISYTYEKPEEFWDKFVKRIGLKFYSKYDKV
CCCCCHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LDLSQGKPWAKWFINGKLNIGDQIPDSSEVFIKWMDEKENSRTITYSDVLQQAKAVSSWL
EECCCCCCCEEEEEECEEECCCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHH
KKFGLKKGDTVGIYMPMIPEIVPVFLGIARAGMIAVPLFSGFGKEPIRVRAEDSGMKVIF
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEHHHHCCCCCCEEEEECCCCCEEEE
TTDMTIRKGKEINSLENLEGLTLTKVVVERGGKKDKDSISYSEVLSTAGDGLEVTDTEDP
EECCEEECCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECCCCC
FMIIYTSGTTGKPKGCVHTHDGFPIKASADVYFQFDLKKRETLMWVTDLGWMMGPWMILS
EEEEEECCCCCCCCCCEECCCCCCEEECCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHH
ALLLRGKIGMIEGYTAYSLLSKFIEDMKVDILGLSASLIRAFRSEVEKGKLDVRIVGNTG
HHHHCCCCCEECCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCC
EPIDYESWKWLYEAVKGPIINYSGGTEISGGILGNYVINEIKPTAFNGFSPGIHADVFDE
CCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECC
NGKHAPANVEGELVVLSVWPGMARGFWKDKERYLNTYWSRWEGVWVHGDLAYYDEDGFYY
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEECCCEEE
IVGRSDDTIKVAGKRVGPAEVEQIINSYEGVVESACVGVPDPMKGEEILCFAVTNKEIKK
EEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCH
DELLNYTQRMLGKALAPKDIIFVKELPKTRNAKIMRRLIRAVVLGKPTGDISALENPSAL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
EEIKKALTS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]