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The map label for this gene is tdh [C]

Identifier: 15922008

GI number: 15922008

Start: 1705459

End: 1706541

Strand: Direct

Name: tdh [C]

Synonym: ST1704

Alternate gene names: 15922008

Gene position: 1705459-1706541 (Clockwise)

Preceding gene: 15922004

Following gene: 15922010

Centisome position: 63.29

GC content: 33.7

Gene sequence:

>1083_bases
ATGAAAGCAATAGTTGTTACACCTAAAAAATCTGGAGTAGAAGTCAAAGATATTCCTATGAGAGAGAGTCTAGGAAAGGG
AAAGGTCTTAGTTAAAACGCTATATACTGGAATTTGCGGTACCGATAGAGGAATTGTTAATGCAAAAATAACATTTACAT
ACCCTCCAGACGGTTATAATTTTCTTATATTAGGTCATGAAGGACTTGGCATGGTTGAAGAAGTTGGAGATGGAGTTAAG
TATCTAAAGAAAGGTGATTTTGTAGTACCAGTAGTTAGGAGAGGTTGTGGAGTTTGTTTAAATTGTAGAATTGGAAGACA
AGATTTTTGTGAGACTGGAAAATTTGTTGAAGCTGGAATAAGAGGTAAACATGGTTTTATGAGAGAGGAATTTGTTGATG
ATGAATTATGGTTAGTAAAAGTTCCAGACGAAATAAAAGATATAGCAGTACTAACTGAGCCCTTATCTAATGTTGTAAAA
GCTATAGACGAGTTATTATTTGTTCAAAGAAGAATGATATGGACTTGCGAGGATTCAACATTTGAGTGCAGAAACGCATT
TATAATTGGTAGTGGACCGATAGGTACGTTCTTTTCTTTAATCTTAACTACATTAGGTTTTAACGTTTATATGATTAACA
AAAGAGATCCTTCTCCTATGGAAGATTATATCAGTAAGAGGTTAGGTGTAACTTTTATTAACTCTATGAAAGAAGGAGAT
AAGCTCCCAGAAGCAGATTTAATAGTTGATACTAGTGGAGTTCCTTCCGCATTTATACCTTTAATGAGTAAAATGAGACC
AAATTCAGCATTAATCCTTTTTGGTACATTAGAAGGAGAAAAGTACGAAATAACATCCGATTTAGTTACTTTCATGGTAG
AGAGAAACATAATAGTTATTGGTAGTGTTAACGCTAGTAAGAGAGATTTCCAAGGTGCATTGAACTATTTGAGTATATGG
AAAAATAGATACTATGACGTTCTCCAAAGAATGATAACTTCAAAAGTTTCTGTTGAGCAAGCGCCAGAAGTTTTAATGAG
AAAGCCTAGTGGAGAAATAAAAACAGTTATTGTGTGGGATTAA

Upstream 100 bases:

>100_bases
TGGTGGTATTAAGTAAGTTTTTGAATTTGTCAGTCTTTTCATAACATTCTTTTAGAATTTTTGCATAAAAAATTTTTACT
TCGAAGACCTAAAGAGGTGT

Downstream 100 bases:

>100_bases
CTCTCTTTTCTTACATAATTTCTTAAAACACCTATTTTCTCGACCTCAACTTCTATAACATCTCCGTCTTCAAGGTACTT
TTTACCAGTAAATTCAGCAA

Product: glucose 1-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKAIVVTPKKSGVEVKDIPMRESLGKGKVLVKTLYTGICGTDRGIVNAKITFTYPPDGYNFLILGHEGLGMVEEVGDGVK
YLKKGDFVVPVVRRGCGVCLNCRIGRQDFCETGKFVEAGIRGKHGFMREEFVDDELWLVKVPDEIKDIAVLTEPLSNVVK
AIDELLFVQRRMIWTCEDSTFECRNAFIIGSGPIGTFFSLILTTLGFNVYMINKRDPSPMEDYISKRLGVTFINSMKEGD
KLPEADLIVDTSGVPSAFIPLMSKMRPNSALILFGTLEGEKYEITSDLVTFMVERNIIVIGSVNASKRDFQGALNYLSIW
KNRYYDVLQRMITSKVSVEQAPEVLMRKPSGEIKTVIVWD

Sequences:

>Translated_360_residues
MKAIVVTPKKSGVEVKDIPMRESLGKGKVLVKTLYTGICGTDRGIVNAKITFTYPPDGYNFLILGHEGLGMVEEVGDGVK
YLKKGDFVVPVVRRGCGVCLNCRIGRQDFCETGKFVEAGIRGKHGFMREEFVDDELWLVKVPDEIKDIAVLTEPLSNVVK
AIDELLFVQRRMIWTCEDSTFECRNAFIIGSGPIGTFFSLILTTLGFNVYMINKRDPSPMEDYISKRLGVTFINSMKEGD
KLPEADLIVDTSGVPSAFIPLMSKMRPNSALILFGTLEGEKYEITSDLVTFMVERNIIVIGSVNASKRDFQGALNYLSIW
KNRYYDVLQRMITSKVSVEQAPEVLMRKPSGEIKTVIVWD
>Mature_360_residues
MKAIVVTPKKSGVEVKDIPMRESLGKGKVLVKTLYTGICGTDRGIVNAKITFTYPPDGYNFLILGHEGLGMVEEVGDGVK
YLKKGDFVVPVVRRGCGVCLNCRIGRQDFCETGKFVEAGIRGKHGFMREEFVDDELWLVKVPDEIKDIAVLTEPLSNVVK
AIDELLFVQRRMIWTCEDSTFECRNAFIIGSGPIGTFFSLILTTLGFNVYMINKRDPSPMEDYISKRLGVTFINSMKEGD
KLPEADLIVDTSGVPSAFIPLMSKMRPNSALILFGTLEGEKYEITSDLVTFMVERNIIVIGSVNASKRDFQGALNYLSIW
KNRYYDVLQRMITSKVSVEQAPEVLMRKPSGEIKTVIVWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=27.3356401384083, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082125, Length=365, Percent_Identity=24.6575342465753, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788407, Length=339, Percent_Identity=26.2536873156342, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787863, Length=302, Percent_Identity=25.8278145695364, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081918, Length=151, Percent_Identity=37.0860927152318, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=281, Percent_Identity=24.5551601423488, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=191, Percent_Identity=27.7486910994764, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=27.5471698113208, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 40284; Mature: 40284

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVVTPKKSGVEVKDIPMRESLGKGKVLVKTLYTGICGTDRGIVNAKITFTYPPDGYN
CCEEEECCCCCCCEEECCCCHHCCCCCCEEHHHHHHHCCCCCCCEEEEEEEEEECCCCCE
FLILGHEGLGMVEEVGDGVKYLKKGDFVVPVVRRGCGVCLNCRIGRQDFCETGKFVEAGI
EEEECCCCCCHHHHHCCHHHHHHCCCEEEHHHHCCCCEEEEEECCCHHHHHCCCEEECCC
RGKHGFMREEFVDDELWLVKVPDEIKDIAVLTEPLSNVVKAIDELLFVQRRMIWTCEDST
CCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
FECRNAFIIGSGPIGTFFSLILTTLGFNVYMINKRDPSPMEDYISKRLGVTFINSMKEGD
EEECCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCHHHHHHHHCCC
KLPEADLIVDTSGVPSAFIPLMSKMRPNSALILFGTLEGEKYEITSDLVTFMVERNIIVI
CCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHHHHHHHHCCEEEE
GSVNASKRDFQGALNYLSIWKNRYYDVLQRMITSKVSVEQAPEVLMRKPSGEIKTVIVWD
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MKAIVVTPKKSGVEVKDIPMRESLGKGKVLVKTLYTGICGTDRGIVNAKITFTYPPDGYN
CCEEEECCCCCCCEEECCCCHHCCCCCCEEHHHHHHHCCCCCCCEEEEEEEEEECCCCCE
FLILGHEGLGMVEEVGDGVKYLKKGDFVVPVVRRGCGVCLNCRIGRQDFCETGKFVEAGI
EEEECCCCCCHHHHHCCHHHHHHCCCEEEHHHHCCCCEEEEEECCCHHHHHCCCEEECCC
RGKHGFMREEFVDDELWLVKVPDEIKDIAVLTEPLSNVVKAIDELLFVQRRMIWTCEDST
CCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
FECRNAFIIGSGPIGTFFSLILTTLGFNVYMINKRDPSPMEDYISKRLGVTFINSMKEGD
EEECCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCHHHHHHHHCCC
KLPEADLIVDTSGVPSAFIPLMSKMRPNSALILFGTLEGEKYEITSDLVTFMVERNIIVI
CCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHHHHHHHHCCEEEE
GSVNASKRDFQGALNYLSIWKNRYYDVLQRMITSKVSVEQAPEVLMRKPSGEIKTVIVWD
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8436115; 11029001; 2803257 [H]