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The map label for this gene is 15921989

Identifier: 15921989

GI number: 15921989

Start: 1684892

End: 1686403

Strand: Reverse

Name: 15921989

Synonym: ST1685

Alternate gene names: NA

Gene position: 1686403-1684892 (Counterclockwise)

Preceding gene: 15921990

Following gene: 15921987

Centisome position: 62.58

GC content: 36.71

Gene sequence:

>1512_bases
ATGGTTAGTTGGGAAGTTATAAATAAAGCTACAATATTCATTGCAGAAGAAATGGGAGTTATGTTAAAGAAATCTGCCTT
ATCACCAAATATAAGGGAAAGAATGGATCATAGTTGTGCAATAGTAGATAGAGAAGGTAGAATTGTTGCTCAGGCTGAAC
ATATTCCAGTTCATTTGGGTTCTTTTAAAATTGCGGTTAAAAACGTACTGAAGTTTGCTGAGGAATTAAAAGAAGGGGAA
AGCCTAATATTCAACGACCCCTACATATCTGGGACTCATTTGAATGACGTTGGTATATTAACTCCAATTTATTATGAATC
AGAACTAATGGGTTATGTTATAAATAAGGCTCACCATGTTGATGTAGGTGGTCCATTACCTGGTAGTATAAATCCAAATG
CCAAAACCTTATATGAGGAGGGTATCGTAATTCCTCCCATGAAGTTAACGGATGAAGTAATTAAGTTTGTAAAGGAGAAC
TTTAAAGTTCCAGAGGTTTCTATTGGCGATTTAAATGCTCAAGTTTCAGCTAATAAGACTGGAGTAACTAGGATAAAGCA
ACTCATTGAAAAATACGGTAAGAAGGAAGTTCTTGAAGGTTGGGATAAGAGCATAAACCACACTAGGAATCTTATTCTCC
AGCATAGCTGGAAAGAAGGTGTTTATGAGGCTGAGGACTATTTGGAGTTTAATGATAATCTGCTGAATATAACTTTACAT
TTACATATTAAGAAAGACAAAATTATTGCCGATTTTACTGGTACTCATAGGCAAATAGATGGTCCATTGAATGCTGTTTT
AGGGGTTACTTATTCCGCAGTTTCTTTTGCAATTAGATCAGCCTTAAATAAGGACATACCTACTAATGATGGCTTTTATT
CTTTCATAGAAGTTATTGCTGAAGAAGGTTCTTTAGTAAATCCTAAAAAGCCTGCTGCCGTTGGTGGTGGTAATGTTGAA
ACTTCACAAAGAATTGCTGATGTTACTTTTTTAGCCCTATCCCGTTTTCTATCTTATATTCCAGCAGCTAGTTCTGGGAC
TATGATGAACGTTATGATGGGTGGTATTTATCAAGGTAAATATTGGTCTTATTACGAGACAATAGCTGGTGGCAGTGGTG
CTAGGCCTAATTCTGATGGAGTATCGGCTGTTCACACAAATATGACTAATACTTTAAATACTCCAATTGAGATTGCAGAA
ATGAACTATCCCATTCTCTTTACCTCATATAGGATAAGGGCTGGAAGTGGTGGTAAGGGAGTTCATAAAGGTGGTGACGG
TATAATTAGGAGTTTTAAAGTTCTTTCTCCCACGAGGCTTTCTATTTTAGCTGATAGGTTCAAGACCTCTCCATGGGGTT
TAAATGGTGGTGAAAATGGTAAGCCTGGAAGAGTTTATATAATAAAGAAGGGAGAGAGAATGGAAATGCCTAGTAAATTT
ACGATAGATTTGCATGAAGGAGATGAGGTGATTATTGAAACTCCAGGCGGTGGTGGTTATTCAAGGTCTTAG

Upstream 100 bases:

>100_bases
CGGCAATCATAGAAGAATACAGTGCAACAACATTAATTCCAGATGGTTGGAGTTTTACTATTCTCCCTAATTATTTCATA
GAATTAACGAGGGAGTAAAA

Downstream 100 bases:

>100_bases
AGCAAGGATAATACTGTTAATTATTGACATTACAAGAAGGGAACCTATATAAGCCGTTATGCCAGAGATTAAGTTACTAT
AGATTTTTTCACTAAAAGAG

Product: N-methylhydantoinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MVSWEVINKATIFIAEEMGVMLKKSALSPNIRERMDHSCAIVDREGRIVAQAEHIPVHLGSFKIAVKNVLKFAEELKEGE
SLIFNDPYISGTHLNDVGILTPIYYESELMGYVINKAHHVDVGGPLPGSINPNAKTLYEEGIVIPPMKLTDEVIKFVKEN
FKVPEVSIGDLNAQVSANKTGVTRIKQLIEKYGKKEVLEGWDKSINHTRNLILQHSWKEGVYEAEDYLEFNDNLLNITLH
LHIKKDKIIADFTGTHRQIDGPLNAVLGVTYSAVSFAIRSALNKDIPTNDGFYSFIEVIAEEGSLVNPKKPAAVGGGNVE
TSQRIADVTFLALSRFLSYIPAASSGTMMNVMMGGIYQGKYWSYYETIAGGSGARPNSDGVSAVHTNMTNTLNTPIEIAE
MNYPILFTSYRIRAGSGGKGVHKGGDGIIRSFKVLSPTRLSILADRFKTSPWGLNGGENGKPGRVYIIKKGERMEMPSKF
TIDLHEGDEVIIETPGGGGYSRS

Sequences:

>Translated_503_residues
MVSWEVINKATIFIAEEMGVMLKKSALSPNIRERMDHSCAIVDREGRIVAQAEHIPVHLGSFKIAVKNVLKFAEELKEGE
SLIFNDPYISGTHLNDVGILTPIYYESELMGYVINKAHHVDVGGPLPGSINPNAKTLYEEGIVIPPMKLTDEVIKFVKEN
FKVPEVSIGDLNAQVSANKTGVTRIKQLIEKYGKKEVLEGWDKSINHTRNLILQHSWKEGVYEAEDYLEFNDNLLNITLH
LHIKKDKIIADFTGTHRQIDGPLNAVLGVTYSAVSFAIRSALNKDIPTNDGFYSFIEVIAEEGSLVNPKKPAAVGGGNVE
TSQRIADVTFLALSRFLSYIPAASSGTMMNVMMGGIYQGKYWSYYETIAGGSGARPNSDGVSAVHTNMTNTLNTPIEIAE
MNYPILFTSYRIRAGSGGKGVHKGGDGIIRSFKVLSPTRLSILADRFKTSPWGLNGGENGKPGRVYIIKKGERMEMPSKF
TIDLHEGDEVIIETPGGGGYSRS
>Mature_503_residues
MVSWEVINKATIFIAEEMGVMLKKSALSPNIRERMDHSCAIVDREGRIVAQAEHIPVHLGSFKIAVKNVLKFAEELKEGE
SLIFNDPYISGTHLNDVGILTPIYYESELMGYVINKAHHVDVGGPLPGSINPNAKTLYEEGIVIPPMKLTDEVIKFVKEN
FKVPEVSIGDLNAQVSANKTGVTRIKQLIEKYGKKEVLEGWDKSINHTRNLILQHSWKEGVYEAEDYLEFNDNLLNITLH
LHIKKDKIIADFTGTHRQIDGPLNAVLGVTYSAVSFAIRSALNKDIPTNDGFYSFIEVIAEEGSLVNPKKPAAVGGGNVE
TSQRIADVTFLALSRFLSYIPAASSGTMMNVMMGGIYQGKYWSYYETIAGGSGARPNSDGVSAVHTNMTNTLNTPIEIAE
MNYPILFTSYRIRAGSGGKGVHKGGDGIIRSFKVLSPTRLSILADRFKTSPWGLNGGENGKPGRVYIIKKGERMEMPSKF
TIDLHEGDEVIIETPGGGGYSRS

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=529, Percent_Identity=34.593572778828, Blast_Score=285, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI133901900, Length=517, Percent_Identity=37.137330754352, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI133901902, Length=501, Percent_Identity=36.3273453093812, Blast_Score=293, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322634, Length=530, Percent_Identity=37.5471698113208, Blast_Score=311, Evalue=1e-85,
Organism=Drosophila melanogaster, GI45550492, Length=532, Percent_Identity=34.9624060150376, Blast_Score=297, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 55280; Mature: 55280

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSWEVINKATIFIAEEMGVMLKKSALSPNIRERMDHSCAIVDREGRIVAQAEHIPVHLG
CCCCEEECCEEEEEEHHHCHHHHHHCCCCCHHHHCCCCEEEEECCCCEEEEECCCEEEEC
SFKIAVKNVLKFAEELKEGESLIFNDPYISGTHLNDVGILTPIYYESELMGYVINKAHHV
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEE
DVGGPLPGSINPNAKTLYEEGIVIPPMKLTDEVIKFVKENFKVPEVSIGDLNAQVSANKT
ECCCCCCCCCCCCHHHHHHCCEEECCHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCCH
GVTRIKQLIEKYGKKEVLEGWDKSINHTRNLILQHSWKEGVYEAEDYLEFNDNLLNITLH
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECHHCCCCCCHHHHCCCCCEEEEEEE
LHIKKDKIIADFTGTHRQIDGPLNAVLGVTYSAVSFAIRSALNKDIPTNDGFYSFIEVIA
EEEECCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EEGSLVNPKKPAAVGGGNVETSQRIADVTFLALSRFLSYIPAASSGTMMNVMMGGIYQGK
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEECCC
YWSYYETIAGGSGARPNSDGVSAVHTNMTNTLNTPIEIAEMNYPILFTSYRIRAGSGGKG
CHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEEEEECCCCCC
VHKGGDGIIRSFKVLSPTRLSILADRFKTSPWGLNGGENGKPGRVYIIKKGERMEMPSKF
CCCCCCHHHHHHECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
TIDLHEGDEVIIETPGGGGYSRS
EEEEECCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MVSWEVINKATIFIAEEMGVMLKKSALSPNIRERMDHSCAIVDREGRIVAQAEHIPVHLG
CCCCEEECCEEEEEEHHHCHHHHHHCCCCCHHHHCCCCEEEEECCCCEEEEECCCEEEEC
SFKIAVKNVLKFAEELKEGESLIFNDPYISGTHLNDVGILTPIYYESELMGYVINKAHHV
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEE
DVGGPLPGSINPNAKTLYEEGIVIPPMKLTDEVIKFVKENFKVPEVSIGDLNAQVSANKT
ECCCCCCCCCCCCHHHHHHCCEEECCHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCCH
GVTRIKQLIEKYGKKEVLEGWDKSINHTRNLILQHSWKEGVYEAEDYLEFNDNLLNITLH
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECHHCCCCCCHHHHCCCCCEEEEEEE
LHIKKDKIIADFTGTHRQIDGPLNAVLGVTYSAVSFAIRSALNKDIPTNDGFYSFIEVIA
EEEECCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EEGSLVNPKKPAAVGGGNVETSQRIADVTFLALSRFLSYIPAASSGTMMNVMMGGIYQGK
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEECCC
YWSYYETIAGGSGARPNSDGVSAVHTNMTNTLNTPIEIAEMNYPILFTSYRIRAGSGGKG
CHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEEEEECCCCCC
VHKGGDGIIRSFKVLSPTRLSILADRFKTSPWGLNGGENGKPGRVYIIKKGERMEMPSKF
CCCCCCHHHHHHECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
TIDLHEGDEVIIETPGGGGYSRS
EEEEECCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]