Click here to switch to the map view.

The map label for this gene is gppA [H]

Identifier: 15921838

GI number: 15921838

Start: 1537655

End: 1538908

Strand: Reverse

Name: gppA [H]

Synonym: ST1544

Alternate gene names: 15921838

Gene position: 1538908-1537655 (Counterclockwise)

Preceding gene: 15921840

Following gene: 15921837

Centisome position: 57.11

GC content: 33.41

Gene sequence:

>1254_bases
ATGTTATCAGCAGTTATTGATGCTGGTTTTAATTCCTTTCGTTTAGTTCTATACCAGGTTTTCCCTAATGGAACTTTTAG
AATTATAGGCTCGATTAAGTCTTTTGTAAGAATAGGAGAAGGGTTAGAAGAAGGAAAACCTATAGGAGAGAGTAAAATTA
GAGAAGCTGAAGAAGCCTTTTCGATTTTTAAGAAGATCATTGATAAAGAGAAAGTAGAGGATGTTAAAATAGTTGCTACT
AGTGCGTTTAGATACGCCACTAACGGTAATGAGATTGCCCAGAAATTAAGTAAACTCATAGGATATGAAATGAAAATTAT
TTCTGGAGAAGAAGAGGGAAGATTTTCCGGGATTGGAATCCTAAATACTTTACCCGTCTCTAACGGCATACTTTTTGAAC
TTGGAGGAGGTTCTCTTGAACTAATTGAGGTTAATGAGGGAAATATTGGTAAAGTTTATCAGTTACCTATAGGTGCATTA
AAACTCTTGAATTACCAAGAAAAAGAGATAAGAAAAAGAGTGAAAGATCAGTTATCAACGCTCTCTCTGAAAAGACAAGG
TGTTCTAGTTGGATCTGGAGGTAATGTGAGAGCTTTGGCAAAAATGGATTTAAAACTTTTATCTTATCCAACAAGATCAA
TTCATGGTTATTCAATTCCATCAAAACAAATAAGTAAATATTCCTCACTTCTTCCTACTTTAGATGTAGATGCAAGAGCC
TCTCTCCCCGGAATTGGAAAAGAAAGAGCTTTCACGATACATACAGCATCAATCATCATAGATGAGCTAATGAAATATTT
TAATGCGGAAAATCTAATTGTTTCTGCTTATGGTATGAGGGAAGGAGTACTTACAGAAGGAAGAAGACTGAATAGAGAGA
GTTGGTTGTATGGGATAGCATACTTTAATGCGTTAGAGCCGCCAATTCAAATATTCAAGGATATAATAGATAGTGTAGGA
GGAAAGTACTCGTTTTATATTGCTTCATCAGCCTATTTATCCCTAATATTTAAGATGTCTGGTTATCTCAATCCTTATGA
GGCTTGTTATAGGTTTATCAAGAATTCTGTTTTGCCAGGTTTTCTTTTAGAAGAAGCTTTAATAATAAGCTTTATATGTA
AATCTACATATAGTAAAATAAAGAAAAAGCATATTAAATTTTTAAGTGAAAAACCGAGTAAAAAAGAGCTATCATCTTAT
GGAAATATAGTGAAAAACGCGGTTGAGAAATATGTTAATGGTGTTAGACTATGA

Upstream 100 bases:

>100_bases
TTAAGAAAGGAGGTATGGCTATGGTTGATTATGATTTAAAAGAAAACAAAGGTGTTTTAAAAATGCTTTTAACTCAGAAG
GTGCTTAAGATGATTTAATT

Downstream 100 bases:

>100_bases
AAAAGGGAGTTCTAATAGCTTTTGAAGGAATTGATGGATCTGGTAAATCAAGTCAGGCTACGTTACTTAAGGATTGGATA
GAATTAAAAAGAGATGTCTA

Product: exopolyphosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLSAVIDAGFNSFRLVLYQVFPNGTFRIIGSIKSFVRIGEGLEEGKPIGESKIREAEEAFSIFKKIIDKEKVEDVKIVAT
SAFRYATNGNEIAQKLSKLIGYEMKIISGEEEGRFSGIGILNTLPVSNGILFELGGGSLELIEVNEGNIGKVYQLPIGAL
KLLNYQEKEIRKRVKDQLSTLSLKRQGVLVGSGGNVRALAKMDLKLLSYPTRSIHGYSIPSKQISKYSSLLPTLDVDARA
SLPGIGKERAFTIHTASIIIDELMKYFNAENLIVSAYGMREGVLTEGRRLNRESWLYGIAYFNALEPPIQIFKDIIDSVG
GKYSFYIASSAYLSLIFKMSGYLNPYEACYRFIKNSVLPGFLLEEALIISFICKSTYSKIKKKHIKFLSEKPSKKELSSY
GNIVKNAVEKYVNGVRL

Sequences:

>Translated_417_residues
MLSAVIDAGFNSFRLVLYQVFPNGTFRIIGSIKSFVRIGEGLEEGKPIGESKIREAEEAFSIFKKIIDKEKVEDVKIVAT
SAFRYATNGNEIAQKLSKLIGYEMKIISGEEEGRFSGIGILNTLPVSNGILFELGGGSLELIEVNEGNIGKVYQLPIGAL
KLLNYQEKEIRKRVKDQLSTLSLKRQGVLVGSGGNVRALAKMDLKLLSYPTRSIHGYSIPSKQISKYSSLLPTLDVDARA
SLPGIGKERAFTIHTASIIIDELMKYFNAENLIVSAYGMREGVLTEGRRLNRESWLYGIAYFNALEPPIQIFKDIIDSVG
GKYSFYIASSAYLSLIFKMSGYLNPYEACYRFIKNSVLPGFLLEEALIISFICKSTYSKIKKKHIKFLSEKPSKKELSSY
GNIVKNAVEKYVNGVRL
>Mature_417_residues
MLSAVIDAGFNSFRLVLYQVFPNGTFRIIGSIKSFVRIGEGLEEGKPIGESKIREAEEAFSIFKKIIDKEKVEDVKIVAT
SAFRYATNGNEIAQKLSKLIGYEMKIISGEEEGRFSGIGILNTLPVSNGILFELGGGSLELIEVNEGNIGKVYQLPIGAL
KLLNYQEKEIRKRVKDQLSTLSLKRQGVLVGSGGNVRALAKMDLKLLSYPTRSIHGYSIPSKQISKYSSLLPTLDVDARA
SLPGIGKERAFTIHTASIIIDELMKYFNAENLIVSAYGMREGVLTEGRRLNRESWLYGIAYFNALEPPIQIFKDIIDSVG
GKYSFYIASSAYLSLIFKMSGYLNPYEACYRFIKNSVLPGFLLEEALIISFICKSTYSKIKKKHIKFLSEKPSKKELSSY
GNIVKNAVEKYVNGVRL

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=411, Percent_Identity=24.5742092457421, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI48994966, Length=307, Percent_Identity=23.1270358306189, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 46449; Mature: 46449

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSAVIDAGFNSFRLVLYQVFPNGTFRIIGSIKSFVRIGEGLEEGKPIGESKIREAEEAF
CCCHHHHCCCCHHEEEEEEECCCCCEEHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHH
SIFKKIIDKEKVEDVKIVATSAFRYATNGNEIAQKLSKLIGYEMKIISGEEEGRFSGIGI
HHHHHHHHHHHCCCEEEEEEHHHEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEE
LNTLPVSNGILFELGGGSLELIEVNEGNIGKVYQLPIGALKLLNYQEKEIRKRVKDQLST
EEECCCCCCEEEEECCCEEEEEEECCCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHH
LSLKRQGVLVGSGGNVRALAKMDLKLLSYPTRSIHGYSIPSKQISKYSSLLPTLDVDARA
HHHHHCEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
SLPGIGKERAFTIHTASIIIDELMKYFNAENLIVSAYGMREGVLTEGRRLNRESWLYGIA
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHH
YFNALEPPIQIFKDIIDSVGGKYSFYIASSAYLSLIFKMSGYLNPYEACYRFIKNSVLPG
HHHCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
FLLEEALIISFICKSTYSKIKKKHIKFLSEKPSKKELSSYGNIVKNAVEKYVNGVRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSAVIDAGFNSFRLVLYQVFPNGTFRIIGSIKSFVRIGEGLEEGKPIGESKIREAEEAF
CCCHHHHCCCCHHEEEEEEECCCCCEEHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHH
SIFKKIIDKEKVEDVKIVATSAFRYATNGNEIAQKLSKLIGYEMKIISGEEEGRFSGIGI
HHHHHHHHHHHCCCEEEEEEHHHEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEE
LNTLPVSNGILFELGGGSLELIEVNEGNIGKVYQLPIGALKLLNYQEKEIRKRVKDQLST
EEECCCCCCEEEEECCCEEEEEEECCCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHH
LSLKRQGVLVGSGGNVRALAKMDLKLLSYPTRSIHGYSIPSKQISKYSSLLPTLDVDARA
HHHHHCEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
SLPGIGKERAFTIHTASIIIDELMKYFNAENLIVSAYGMREGVLTEGRRLNRESWLYGIA
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHH
YFNALEPPIQIFKDIIDSVGGKYSFYIASSAYLSLIFKMSGYLNPYEACYRFIKNSVLPG
HHHCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
FLLEEALIISFICKSTYSKIKKKHIKFLSEKPSKKELSSYGNIVKNAVEKYVNGVRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA