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The map label for this gene is argE [C]

Identifier: 15921822

GI number: 15921822

Start: 1521606

End: 1522754

Strand: Direct

Name: argE [C]

Synonym: ST1529

Alternate gene names: 15921822

Gene position: 1521606-1522754 (Clockwise)

Preceding gene: 15921820

Following gene: 15921824

Centisome position: 56.47

GC content: 33.33

Gene sequence:

>1149_bases
ATGGAAATAGAGGAATTAACCTCAAAATTAATTCAATTTCCTACAGTAAATCCACCAGCTGAAAACCTACATGATTGTGC
CTCATTTATAAAAGATTATCTTTCATCTCAGGGTTTTTCATCTCAAGTTATAGAGTTTGAAAAGGGCTGGCCAGTTGTTA
TTTCCGAAAATGGCAATAAAAATGACAAGCTAATAATGTTAAACGGCCATTATGATGTTGTCCCTACTGGAGATGTTAAT
AAGTGGAAATACAATCCTTTTTCTGGAAAGATCATTGATGATAAAGTTTACGGGCGAGGAAGTACTGATATGAAAGGAGG
CTTAGCCGTTTTCATGAAAGTATTTACTGAAATAGCCGATAAAGTTAATTATAACCTTATTTTCACAGCTGTTCCAGATG
AAGAAAGTGGTGGTGATAAAGGGTCAAAATATTTAGCTGATAGATATAAGCCAGATTTAGTACTCATATCTGAACCATCC
GGTTCAGATTCTATAAACATTGGTGAAAAAGGGCTATTGCAAGTAAAGTTAATCGCTAAAGGTAAGGTTGCTCATGGAAG
TCTTCCATCTTTAGGTGAAAATGCAATAATGAAACTCGTTAAGGATTTAATTCAACTTGAAAAAATAAAAGAGATTGAAA
TAAAAATCCCAGATAATCTCATAGAAGCGATGACAGCAAGAATACCTTCCGAAATTGCTAAGAATGATGTATTGAGGATT
TCCTTTAATCCCGGTGTAATTAAAGGCGGAGTTAAGGTTAATGTAGTTCCAGATTACGCTGAAGTTGAAGTTGATATGAG
AATACCTCCTGGAATAAATAGTGGTGAAGCATTAAATATTGTAAGGAGTCTTGTGAAACAAGGTGAAATAATACCTCTAG
ATATCTCAGAGCCTAATTATACTCCTCCAGATAATGAGTTTGTGAAAAAATTGGAAAATATTATATATAAACAGCTAGGA
ATTAAAGCTAAGAAATATATTATTACTGGTGCTACAGATGGTAGATATTTTAGATATAAAGGAGTTCCAGTAATAGTTTA
CGGTCCAGGAGAGCTAGGTATGGCTCACGCTTATGACGAGTTTATTTCATTTAAAGAATTAAGAAATTCCTATACTGTTA
TAAAAGATTATTTATTAACCCTCTTCTAG

Upstream 100 bases:

>100_bases
TTCAATATCATATTTTTATATTATCTTCTATTCTTTTTAGATTTTTCTTCTATCATTCATAATATTAAATCCTTTTAATC
AGAATGCTTAAAAATAATTT

Downstream 100 bases:

>100_bases
GTATCTAAAGATTAATGAAGAGATGAATAGTAAAATCCCAGCTGTTATGAAGTCAATTCCATAACTTAAATAATGAGTTA
TATATCCAGATAGAAGACTA

Product: succinyl-diaminopimelate desuccinylase

Products: succinate; LL-2,6-diaminoheptanedioate

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MEIEELTSKLIQFPTVNPPAENLHDCASFIKDYLSSQGFSSQVIEFEKGWPVVISENGNKNDKLIMLNGHYDVVPTGDVN
KWKYNPFSGKIIDDKVYGRGSTDMKGGLAVFMKVFTEIADKVNYNLIFTAVPDEESGGDKGSKYLADRYKPDLVLISEPS
GSDSINIGEKGLLQVKLIAKGKVAHGSLPSLGENAIMKLVKDLIQLEKIKEIEIKIPDNLIEAMTARIPSEIAKNDVLRI
SFNPGVIKGGVKVNVVPDYAEVEVDMRIPPGINSGEALNIVRSLVKQGEIIPLDISEPNYTPPDNEFVKKLENIIYKQLG
IKAKKYIITGATDGRYFRYKGVPVIVYGPGELGMAHAYDEFISFKELRNSYTVIKDYLLTLF

Sequences:

>Translated_382_residues
MEIEELTSKLIQFPTVNPPAENLHDCASFIKDYLSSQGFSSQVIEFEKGWPVVISENGNKNDKLIMLNGHYDVVPTGDVN
KWKYNPFSGKIIDDKVYGRGSTDMKGGLAVFMKVFTEIADKVNYNLIFTAVPDEESGGDKGSKYLADRYKPDLVLISEPS
GSDSINIGEKGLLQVKLIAKGKVAHGSLPSLGENAIMKLVKDLIQLEKIKEIEIKIPDNLIEAMTARIPSEIAKNDVLRI
SFNPGVIKGGVKVNVVPDYAEVEVDMRIPPGINSGEALNIVRSLVKQGEIIPLDISEPNYTPPDNEFVKKLENIIYKQLG
IKAKKYIITGATDGRYFRYKGVPVIVYGPGELGMAHAYDEFISFKELRNSYTVIKDYLLTLF
>Mature_382_residues
MEIEELTSKLIQFPTVNPPAENLHDCASFIKDYLSSQGFSSQVIEFEKGWPVVISENGNKNDKLIMLNGHYDVVPTGDVN
KWKYNPFSGKIIDDKVYGRGSTDMKGGLAVFMKVFTEIADKVNYNLIFTAVPDEESGGDKGSKYLADRYKPDLVLISEPS
GSDSINIGEKGLLQVKLIAKGKVAHGSLPSLGENAIMKLVKDLIQLEKIKEIEIKIPDNLIEAMTARIPSEIAKNDVLRI
SFNPGVIKGGVKVNVVPDYAEVEVDMRIPPGINSGEALNIVRSLVKQGEIIPLDISEPNYTPPDNEFVKKLENIIYKQLG
IKAKKYIITGATDGRYFRYKGVPVIVYGPGELGMAHAYDEFISFKELRNSYTVIKDYLLTLF

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=356, Percent_Identity=24.438202247191, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790395, Length=398, Percent_Identity=26.3819095477387, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788816, Length=383, Percent_Identity=23.7597911227154, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789236, Length=333, Percent_Identity=23.4234234234234, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538642, Length=364, Percent_Identity=28.2967032967033, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71982710, Length=377, Percent_Identity=27.8514588859416, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538640, Length=365, Percent_Identity=28.4931506849315, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24649210, Length=395, Percent_Identity=29.620253164557, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24649202, Length=378, Percent_Identity=26.4550264550265, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24649204, Length=378, Percent_Identity=26.4550264550265, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24649208, Length=375, Percent_Identity=27.2, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24649206, Length=382, Percent_Identity=27.4869109947644, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24649212, Length=389, Percent_Identity=28.2776349614396, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.18

Molecular weight: Translated: 42398; Mature: 42398

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEELTSKLIQFPTVNPPAENLHDCASFIKDYLSSQGFSSQVIEFEKGWPVVISENGNK
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCEEEECCCCC
NDKLIMLNGHYDVVPTGDVNKWKYNPFSGKIIDDKVYGRGSTDMKGGLAVFMKVFTEIAD
CCEEEEEECCEEEEECCCCCCEEECCCCCCEECCEECCCCCCCCCCHHHHHHHHHHHHHH
KVNYNLIFTAVPDEESGGDKGSKYLADRYKPDLVLISEPSGSDSINIGEKGLLQVKLIAK
HCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEC
GKVAHGSLPSLGENAIMKLVKDLIQLEKIKEIEIKIPDNLIEAMTARIPSEIAKNDVLRI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCHHHHHCCCEEEE
SFNPGVIKGGVKVNVVPDYAEVEVDMRIPPGINSGEALNIVRSLVKQGEIIPLDISEPNY
EECCCEEECCEEEEEECCHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCC
TPPDNEFVKKLENIIYKQLGIKAKKYIITGATDGRYFRYKGVPVIVYGPGELGMAHAYDE
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCHHHHHHH
FISFKELRNSYTVIKDYLLTLF
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIEELTSKLIQFPTVNPPAENLHDCASFIKDYLSSQGFSSQVIEFEKGWPVVISENGNK
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCEEEECCCCC
NDKLIMLNGHYDVVPTGDVNKWKYNPFSGKIIDDKVYGRGSTDMKGGLAVFMKVFTEIAD
CCEEEEEECCEEEEECCCCCCEEECCCCCCEECCEECCCCCCCCCCHHHHHHHHHHHHHH
KVNYNLIFTAVPDEESGGDKGSKYLADRYKPDLVLISEPSGSDSINIGEKGLLQVKLIAK
HCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEC
GKVAHGSLPSLGENAIMKLVKDLIQLEKIKEIEIKIPDNLIEAMTARIPSEIAKNDVLRI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCHHHHHCCCEEEE
SFNPGVIKGGVKVNVVPDYAEVEVDMRIPPGINSGEALNIVRSLVKQGEIIPLDISEPNY
EECCCEEECCEEEEEECCHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCC
TPPDNEFVKKLENIIYKQLGIKAKKYIITGATDGRYFRYKGVPVIVYGPGELGMAHAYDE
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEECCEEEEEECCCCCCHHHHHHH
FISFKELRNSYTVIKDYLLTLF
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-LL-2,6-diaminoheptanedioate; H2O

Specific reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]