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The map label for this gene is hisG

Identifier: 15921752

GI number: 15921752

Start: 1464158

End: 1465009

Strand: Direct

Name: hisG

Synonym: ST1459

Alternate gene names: 15921752

Gene position: 1464158-1465009 (Clockwise)

Preceding gene: 15921751

Following gene: 15921753

Centisome position: 54.33

GC content: 34.04

Gene sequence:

>852_bases
ATGGCAATTCCAAATAAAGGCAGATTAAAAGATCCTGTTGTTCAATTTTTAGCTTCAGTAGGAGTGAAAGGGAATTTCTC
CGATGATAGAGCTTTAATAATACCCACTAATTGGGAGGGAGTACAACTAGTTATGGTTAGGACTGAGGATATTCCTAGTA
TAGTAGAATCTGGTGCCGCAGAGTTAGGAATAACTGGGCATGATTATGTAATTGAGTCAAATTCTGATGTTGATGAATTA
ATCAGACTTGATTTTGGAAAATCAAAAATTGTCTTAGCTGTTCCAGTGAGTTGGAATATTGACAGAGTTGAAGAAATTAA
AGATGAAATAAGGATAGCTACAAAGTACTATAATATCGCAAAACAGTATCTTGAAAAGAAGAATATAAAAGCTAAAATAG
TTAAAATCAGTGGTGCTGCAGAAGTAATGCCATCTTTGGGTGCTGCAGATGCTATAATAGATGTTATGAGTACTGGGACT
ACTCTAAAACTTCATGGCTTAAAACCTTTAGATACAATTTTAGAAAGTAGTGCTGTGGTTATCGCGAATAGAAATTGGGT
AAAAAGCGAAGAAGCTGATAAAATAAATTTGCTTTTAACCATGATGAAAGGGGCTTTAATGGCAAGAAATAAGAAAATGA
TATTTATGAATGTTCCAGATGATAAATTGGATAAAGTTATAGCATCACTTCCAGCTATGCTTTCTCCAACGCTATCAAAA
CTAGCAAAAAGTGATGCATGGGAAGTTATAACGGTGGTTGATGAAGATCTTATACCGGAAGTAATAGCTAAAGTAAAAGC
TAATGGTGCTAGGGATATTGTAGTAGTTAATATAGAGAAAGTGGTGAAATAA

Upstream 100 bases:

>100_bases
GTAGCGATTAGAAAACCAATTATAGGTTATTATAGGATAAGTGTAGGCACAAAGGAACAGGTTGATACTCTATTAAAATA
TTTAGGTGAGATAATTGAAA

Downstream 100 bases:

>100_bases
TGCTAAAAGTCGTACCCAGTATTGATATTAGTGAAGGGAAGGCAGTGAAAAGGATAAGAGGTGTAAAAGGCTCTGGTTTA
ATTCTCGGTAACCCCGTTAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAIPNKGRLKDPVVQFLASVGVKGNFSDDRALIIPTNWEGVQLVMVRTEDIPSIVESGAAELGITGHDYVIESNSDVDEL
IRLDFGKSKIVLAVPVSWNIDRVEEIKDEIRIATKYYNIAKQYLEKKNIKAKIVKISGAAEVMPSLGAADAIIDVMSTGT
TLKLHGLKPLDTILESSAVVIANRNWVKSEEADKINLLLTMMKGALMARNKKMIFMNVPDDKLDKVIASLPAMLSPTLSK
LAKSDAWEVITVVDEDLIPEVIAKVKANGARDIVVVNIEKVVK

Sequences:

>Translated_283_residues
MAIPNKGRLKDPVVQFLASVGVKGNFSDDRALIIPTNWEGVQLVMVRTEDIPSIVESGAAELGITGHDYVIESNSDVDEL
IRLDFGKSKIVLAVPVSWNIDRVEEIKDEIRIATKYYNIAKQYLEKKNIKAKIVKISGAAEVMPSLGAADAIIDVMSTGT
TLKLHGLKPLDTILESSAVVIANRNWVKSEEADKINLLLTMMKGALMARNKKMIFMNVPDDKLDKVIASLPAMLSPTLSK
LAKSDAWEVITVVDEDLIPEVIAKVKANGARDIVVVNIEKVVK
>Mature_282_residues
AIPNKGRLKDPVVQFLASVGVKGNFSDDRALIIPTNWEGVQLVMVRTEDIPSIVESGAAELGITGHDYVIESNSDVDELI
RLDFGKSKIVLAVPVSWNIDRVEEIKDEIRIATKYYNIAKQYLEKKNIKAKIVKISGAAEVMPSLGAADAIIDVMSTGTT
LKLHGLKPLDTILESSAVVIANRNWVKSEEADKINLLLTMMKGALMARNKKMIFMNVPDDKLDKVIASLPAMLSPTLSKL
AKSDAWEVITVVDEDLIPEVIAKVKANGARDIVVVNIEKVVK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=35.1535836177474, Blast_Score=157, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6320896, Length=287, Percent_Identity=31.7073170731707, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SULTO (Q970Z3)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377421.1
- ProteinModelPortal:   Q970Z3
- SMR:   Q970Z3
- GeneID:   1459494
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1459
- NMPDR:   fig|273063.1.peg.1589
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   STOK273063:ST1459-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 30986; Mature: 30854

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPNKGRLKDPVVQFLASVGVKGNFSDDRALIIPTNWEGVQLVMVRTEDIPSIVESGAA
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHCCCC
ELGITGHDYVIESNSDVDELIRLDFGKSKIVLAVPVSWNIDRVEEIKDEIRIATKYYNIA
CCCCCCCCEEEECCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
KQYLEKKNIKAKIVKISGAAEVMPSLGAADAIIDVMSTGTTLKLHGLKPLDTILESSAVV
HHHHHHCCCEEEEEEECCHHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHHHHHCCCEEE
IANRNWVKSEEADKINLLLTMMKGALMARNKKMIFMNVPDDKLDKVIASLPAMLSPTLSK
EECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCHHHHH
LAKSDAWEVITVVDEDLIPEVIAKVKANGARDIVVVNIEKVVK
HHCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEEHHHHCC
>Mature Secondary Structure 
AIPNKGRLKDPVVQFLASVGVKGNFSDDRALIIPTNWEGVQLVMVRTEDIPSIVESGAA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHCCCC
ELGITGHDYVIESNSDVDELIRLDFGKSKIVLAVPVSWNIDRVEEIKDEIRIATKYYNIA
CCCCCCCCEEEECCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
KQYLEKKNIKAKIVKISGAAEVMPSLGAADAIIDVMSTGTTLKLHGLKPLDTILESSAVV
HHHHHHCCCEEEEEEECCHHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHHHHHCCCEEE
IANRNWVKSEEADKINLLLTMMKGALMARNKKMIFMNVPDDKLDKVIASLPAMLSPTLSK
EECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCHHHHH
LAKSDAWEVITVVDEDLIPEVIAKVKANGARDIVVVNIEKVVK
HHCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479