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The map label for this gene is ilvC

Identifier: 15921736

GI number: 15921736

Start: 1449866

End: 1450864

Strand: Reverse

Name: ilvC

Synonym: ST1445

Alternate gene names: 15921736

Gene position: 1450864-1449866 (Counterclockwise)

Preceding gene: 15921737

Following gene: 15921735

Centisome position: 53.84

GC content: 36.54

Gene sequence:

>999_bases
GTGGCAAAAGTATATATTGATAAAGATGCAAGTTTAGATCCTATAAAGGATAAAACAATAGCTGTACTAGGATATGGAAG
TCAAGGAAGAGCTTGGGCGCTTAACCTTAGAGATTCTGGATTAAAGGTACTTGTGGGATTAGAAAGAGAAGGAAATTCAT
GGAAAGTAGCAGAAAGTGATGGGTTCAACCCAATGCATACAGAAGATGCAGTAAAGAAGTCGGATATAGTAATTTTCTTA
GTACCAGATATGGTCCAAAGATATGTGTATAGAGAAAGAGTAGCACCTTATTTAAGGGATGGAATGGATCTTGTATTCGC
ACATGGATTTAATATCCATTATAAGTTAATAGAACCGCCCAAGACAGTTGATGTTTATATGATAGCACCTAAAGGACCTG
GACCAATAGTAAGAGAATATTTTGCAAAGGGAGGAGGAGTACCAGCTCTAGTAGCAGTACACCAAAACTACTCTGGGAAA
GCTTTTGAAAAAGCATTGGCTATTGCGAAAGCATTAGGAGCTACGAGGGCTGGAGTTATAGAGACGACATTTAAAGAAGA
AACTGAAACTGACCTATTTGGCGAACAAGTTGATTTGGTAGGAGGAATTACACAATTAATGAGGACAGCTTTTCAAGTTT
TAGTTGAAGCCGGCTATCAACCGGAAATAGCTTACTATGAGACTATAAACGAAATGAAAATGATAGTAGATTTAATATAT
GAAAAAGGATTTACAGGAATGTTAAAAGCTGTATCAGAAACAGCTAAATATGGCGGTTTTACTGCAGGAAAATATGTTAT
AAATGAGGATGTAAAGAAGAGAATGAAAGAAGTATTAGATAGAATAAGGAGCGGAAAATTCGCTGAAGAATGGATTGAAG
AATACAATAAAGGAGCACCCACACTTGTTAATGGTATGAAAGAGGTTGAAAACAGCTTGGAAGAACAAGTAGGTAGGCAA
ATTAGAGAGATTTCGCTCAGAGGAAAGCCTAAATCTTAA

Upstream 100 bases:

>100_bases
ACAATAATTGAAGGAGAGCCCTCACAGGCTAGAGAATATGATATAGTTGTTTTTAAACCAGTTTTTACAAAAGTAACAAC
AATCAGTTGGGGGGTTGTAA

Downstream 100 bases:

>100_bases
TTTTTTATATGTATATTGTGAATTCCAATAAATCACGGGGTTCTTCGGTAGAACGTTATATTGTTTCTAGGCTAAGAGAT
AAAGGATTTGCTGTTATAAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MAKVYIDKDASLDPIKDKTIAVLGYGSQGRAWALNLRDSGLKVLVGLEREGNSWKVAESDGFNPMHTEDAVKKSDIVIFL
VPDMVQRYVYRERVAPYLRDGMDLVFAHGFNIHYKLIEPPKTVDVYMIAPKGPGPIVREYFAKGGGVPALVAVHQNYSGK
AFEKALAIAKALGATRAGVIETTFKEETETDLFGEQVDLVGGITQLMRTAFQVLVEAGYQPEIAYYETINEMKMIVDLIY
EKGFTGMLKAVSETAKYGGFTAGKYVINEDVKKRMKEVLDRIRSGKFAEEWIEEYNKGAPTLVNGMKEVENSLEEQVGRQ
IREISLRGKPKS

Sequences:

>Translated_332_residues
MAKVYIDKDASLDPIKDKTIAVLGYGSQGRAWALNLRDSGLKVLVGLEREGNSWKVAESDGFNPMHTEDAVKKSDIVIFL
VPDMVQRYVYRERVAPYLRDGMDLVFAHGFNIHYKLIEPPKTVDVYMIAPKGPGPIVREYFAKGGGVPALVAVHQNYSGK
AFEKALAIAKALGATRAGVIETTFKEETETDLFGEQVDLVGGITQLMRTAFQVLVEAGYQPEIAYYETINEMKMIVDLIY
EKGFTGMLKAVSETAKYGGFTAGKYVINEDVKKRMKEVLDRIRSGKFAEEWIEEYNKGAPTLVNGMKEVENSLEEQVGRQ
IREISLRGKPKS
>Mature_331_residues
AKVYIDKDASLDPIKDKTIAVLGYGSQGRAWALNLRDSGLKVLVGLEREGNSWKVAESDGFNPMHTEDAVKKSDIVIFLV
PDMVQRYVYRERVAPYLRDGMDLVFAHGFNIHYKLIEPPKTVDVYMIAPKGPGPIVREYFAKGGGVPALVAVHQNYSGKA
FEKALAIAKALGATRAGVIETTFKEETETDLFGEQVDLVGGITQLMRTAFQVLVEAGYQPEIAYYETINEMKMIVDLIYE
KGFTGMLKAVSETAKYGGFTAGKYVINEDVKKRMKEVLDRIRSGKFAEEWIEEYNKGAPTLVNGMKEVENSLEEQVGRQI
REISLRGKPKS

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=294, Percent_Identity=34.6938775510204, Blast_Score=144, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=257, Percent_Identity=40.4669260700389, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_SULTO (Q971A9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377405.1
- ProteinModelPortal:   Q971A9
- SMR:   Q971A9
- GeneID:   1459478
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1445
- NMPDR:   fig|273063.1.peg.1573
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   STOK273063:ST1445-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37034; Mature: 36903

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYIDKDASLDPIKDKTIAVLGYGSQGRAWALNLRDSGLKVLVGLEREGNSWKVAESD
CCEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCEEEECCC
GFNPMHTEDAVKKSDIVIFLVPDMVQRYVYRERVAPYLRDGMDLVFAHGFNIHYKLIEPP
CCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCC
KTVDVYMIAPKGPGPIVREYFAKGGGVPALVAVHQNYSGKAFEKALAIAKALGATRAGVI
CCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCE
ETTFKEETETDLFGEQVDLVGGITQLMRTAFQVLVEAGYQPEIAYYETINEMKMIVDLIY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EKGFTGMLKAVSETAKYGGFTAGKYVINEDVKKRMKEVLDRIRSGKFAEEWIEEYNKGAP
HCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
TLVNGMKEVENSLEEQVGRQIREISLRGKPKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKVYIDKDASLDPIKDKTIAVLGYGSQGRAWALNLRDSGLKVLVGLEREGNSWKVAESD
CEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCEEEECCC
GFNPMHTEDAVKKSDIVIFLVPDMVQRYVYRERVAPYLRDGMDLVFAHGFNIHYKLIEPP
CCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCC
KTVDVYMIAPKGPGPIVREYFAKGGGVPALVAVHQNYSGKAFEKALAIAKALGATRAGVI
CCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCE
ETTFKEETETDLFGEQVDLVGGITQLMRTAFQVLVEAGYQPEIAYYETINEMKMIVDLIY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EKGFTGMLKAVSETAKYGGFTAGKYVINEDVKKRMKEVLDRIRSGKFAEEWIEEYNKGAP
HCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
TLVNGMKEVENSLEEQVGRQIREISLRGKPKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479