Click here to switch to the map view.

The map label for this gene is atpA [H]

Identifier: 15921725

GI number: 15921725

Start: 1440051

End: 1441838

Strand: Direct

Name: atpA [H]

Synonym: ST1436

Alternate gene names: 15921725

Gene position: 1440051-1441838 (Clockwise)

Preceding gene: 15921724

Following gene: 15921726

Centisome position: 53.44

GC content: 36.69

Gene sequence:

>1788_bases
GTGAGTAATATGGTCTCTGAAGGTAGGGTCGTGAGAGTAAACGGACCTTTAGTTATAGCTGATGGTATGAGAGAAGCACA
AATGTTTGAGGTAGTATATGTAAGTGATCTTAAATTAGTAGGTGAAATAACAAGAATTGAAGGAGATAGAGCATTTATTC
AAGTTTATGAAAGTACTGACGGTGTAAAACCTGGTGATAAAGTTTATAGATCTGGAGCCCCATTATCAGTAGAATTAGGT
CCTGGGTTAATAGGAAAAATATATGATGGTTTACAGAGACCACTTGATTCTATAGCAAAAGTTTCTAATTCCCCATTTGT
AGCTAGAGGTGTATCTATACCAGCGTTAGATAGACAAACTAAATGGCATTTTGTTCCTAAGGTAAAAAGTGGTGACAAAG
TAGGTCCTGGGGATATAATTGGTGTGGTTCAAGAAACCGACCTTATAGAGCACAGAATTTTAATTCCCCCAAATGTTCAT
GGGACTTTAAAAGAATTAGCTAGAGAAGGAGATTATACTGTGGAAGATGTAGTAGCTGTAGTTGATATGAATGGTGATGA
AATACCAGTAAAAATGTACCAAAAATGGCCAGTCAGAATACCTAGACCTTATAAAGAAAAATTGGAACCAGTAGAGCCCT
TACTAACTGGCATAAGAGTTTTAGACACTGTATTTCCTATTGCAAAAGGTGGAACAGCCGCTATTCCAGGACCTTTCGGT
AGTGGAAAGACTGTAACATTGCAAAGTCTAGCAAAATGGTCTGCTGCAAAGGTTGTAATTTATGTAGGTTGTGGCGAAAG
AGGAAATGAGATGACTGACGAGTTAAGATCTTTCCCGAAGTTAAAAGACCCTTGGACTGGAAAGCCACTCCTATTAAGAA
CTATATTAGTTGCTAATACTAGCAATATGCCAGTAGCAGCTAGAGAATCTAGTATTTATGTTGGAGTTACTATGGCCGAA
TATTTCAGAGATCAAGGTTATGATGTATTACTTGTTGCTGATTCTACGAGTAGATGGGCTGAGGCACTAAGGGATTTAGG
AGGAAGAATGGAAGAGATGCCAGCTGAAGAAGGTTTCCCAAGCTATTTACCGTCTAGATTAGCTGAATATTATGAAAGAG
CTGGAAGAGTTATAGCTCTTGGTAATCCAGAAAGATATGGTTCAGTTACTATAGCTTCTGCAGTTTCTCCTCCTGGAGGT
GATTTTACAGAACCAGTTACTAGCAATACTTTAAGATTTGTAAGAGTTTTTTGGCCTTTAGACGTTTCATTAGCACAAGC
AAGGCATTATCCAGCAATTAATTGGATTCAAGGGTTCTCTGCATACGTGGACTTAGTAGCTCAATGGTGGCATAAGAATG
TAGATCCTAATTGGAAAGAGATGCGTGATACTATGATGAAAGTCTTGATAAGAGAAGATGAGTTAAGACAGATTGTTAGA
TTAGTGGGTCCAGAATCTTTAGCTGAAAAAGATAAATTAGTCCTAGAGGCTGCTAAACTAATAAAAGACGCTTTCCTTAA
ACAGAATGCTTATGATGATATTGATGCCTTTTCTTCACCTCAAAAGCAGGTAAGAATTATGAGGTTAATCTATATATTTT
ATAATCAGTCCCAAGATCTTATCAGTAAAGGTGTTCCATTGAAGAAGATATTAGACAAAGTCGGTCCTATAGAGCCAGAA
ATTATCAGAATTAAATACACGATTAAGAATGATGAGTTAAATAAGATTGACGAGATAGAGAATAAATTAAAAGCTACATT
TGATTCATTATTAAAAGAGGTGAGCTAA

Upstream 100 bases:

>100_bases
TACTATCCCGATAAAAGTTTATCAAAAGATTTTACACTTGAAACAATTTTAAATCAAGTTTTTGATGATATAAGGGATAA
AATAGCCCAAATTTTATTTG

Downstream 100 bases:

>100_bases
ATGAGTCTCCTTAATGTTAGGGAATATTCAAATATTTCAATGATTAAAGGTCCATTAATTGCTGTTCAAGGGGTTAGTGA
TGCAGCTTATAATGAATTAG

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: Sul-ATPase alpha chain; V-ATPase subunit A [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSNMVSEGRVVRVNGPLVIADGMREAQMFEVVYVSDLKLVGEITRIEGDRAFIQVYESTDGVKPGDKVYRSGAPLSVELG
PGLIGKIYDGLQRPLDSIAKVSNSPFVARGVSIPALDRQTKWHFVPKVKSGDKVGPGDIIGVVQETDLIEHRILIPPNVH
GTLKELAREGDYTVEDVVAVVDMNGDEIPVKMYQKWPVRIPRPYKEKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFG
SGKTVTLQSLAKWSAAKVVIYVGCGERGNEMTDELRSFPKLKDPWTGKPLLLRTILVANTSNMPVAARESSIYVGVTMAE
YFRDQGYDVLLVADSTSRWAEALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVIALGNPERYGSVTIASAVSPPGG
DFTEPVTSNTLRFVRVFWPLDVSLAQARHYPAINWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVR
LVGPESLAEKDKLVLEAAKLIKDAFLKQNAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDLISKGVPLKKILDKVGPIEPE
IIRIKYTIKNDELNKIDEIENKLKATFDSLLKEVS

Sequences:

>Translated_595_residues
MSNMVSEGRVVRVNGPLVIADGMREAQMFEVVYVSDLKLVGEITRIEGDRAFIQVYESTDGVKPGDKVYRSGAPLSVELG
PGLIGKIYDGLQRPLDSIAKVSNSPFVARGVSIPALDRQTKWHFVPKVKSGDKVGPGDIIGVVQETDLIEHRILIPPNVH
GTLKELAREGDYTVEDVVAVVDMNGDEIPVKMYQKWPVRIPRPYKEKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFG
SGKTVTLQSLAKWSAAKVVIYVGCGERGNEMTDELRSFPKLKDPWTGKPLLLRTILVANTSNMPVAARESSIYVGVTMAE
YFRDQGYDVLLVADSTSRWAEALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVIALGNPERYGSVTIASAVSPPGG
DFTEPVTSNTLRFVRVFWPLDVSLAQARHYPAINWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVR
LVGPESLAEKDKLVLEAAKLIKDAFLKQNAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDLISKGVPLKKILDKVGPIEPE
IIRIKYTIKNDELNKIDEIENKLKATFDSLLKEVS
>Mature_594_residues
SNMVSEGRVVRVNGPLVIADGMREAQMFEVVYVSDLKLVGEITRIEGDRAFIQVYESTDGVKPGDKVYRSGAPLSVELGP
GLIGKIYDGLQRPLDSIAKVSNSPFVARGVSIPALDRQTKWHFVPKVKSGDKVGPGDIIGVVQETDLIEHRILIPPNVHG
TLKELAREGDYTVEDVVAVVDMNGDEIPVKMYQKWPVRIPRPYKEKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFGS
GKTVTLQSLAKWSAAKVVIYVGCGERGNEMTDELRSFPKLKDPWTGKPLLLRTILVANTSNMPVAARESSIYVGVTMAEY
FRDQGYDVLLVADSTSRWAEALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVIALGNPERYGSVTIASAVSPPGGD
FTEPVTSNTLRFVRVFWPLDVSLAQARHYPAINWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVRL
VGPESLAEKDKLVLEAAKLIKDAFLKQNAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDLISKGVPLKKILDKVGPIEPEI
IRIKYTIKNDELNKIDEIENKLKATFDSLLKEVS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=600, Percent_Identity=48.6666666666667, Blast_Score=562, Evalue=1e-160,
Organism=Homo sapiens, GI32189394, Length=335, Percent_Identity=29.5522388059701, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI19913426, Length=339, Percent_Identity=24.4837758112094, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI19913428, Length=328, Percent_Identity=24.6951219512195, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI50345984, Length=253, Percent_Identity=26.8774703557312, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI4757810, Length=253, Percent_Identity=26.8774703557312, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790170, Length=358, Percent_Identity=29.3296089385475, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788251, Length=260, Percent_Identity=27.6923076923077, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790172, Length=240, Percent_Identity=29.1666666666667, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17565854, Length=545, Percent_Identity=52.8440366972477, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25144756, Length=308, Percent_Identity=29.5454545454545, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17510931, Length=320, Percent_Identity=25.3125, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17570191, Length=326, Percent_Identity=25.1533742331288, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988080, Length=253, Percent_Identity=26.8774703557312, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988063, Length=253, Percent_Identity=26.8774703557312, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71988074, Length=253, Percent_Identity=26.8774703557312, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320016, Length=352, Percent_Identity=44.3181818181818, Blast_Score=319, Evalue=9e-88,
Organism=Saccharomyces cerevisiae, GI6322581, Length=355, Percent_Identity=28.7323943661972, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319603, Length=342, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319370, Length=394, Percent_Identity=23.3502538071066, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583988, Length=600, Percent_Identity=49.5, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583986, Length=600, Percent_Identity=49.5, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583984, Length=600, Percent_Identity=49.5, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583992, Length=596, Percent_Identity=48.8255033557047, Blast_Score=577, Evalue=1e-164,
Organism=Drosophila melanogaster, GI20129479, Length=580, Percent_Identity=49.1379310344828, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24638766, Length=308, Percent_Identity=30.1948051948052, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28574560, Length=307, Percent_Identity=29.6416938110749, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281361666, Length=329, Percent_Identity=24.3161094224924, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646341, Length=329, Percent_Identity=24.3161094224924, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136796, Length=329, Percent_Identity=24.3161094224924, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24658560, Length=254, Percent_Identity=27.1653543307087, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000194
- InterPro:   IPR005726
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 66431; Mature: 66300

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMVSEGRVVRVNGPLVIADGMREAQMFEVVYVSDLKLVGEITRIEGDRAFIQVYESTD
CCCCCCCCEEEEECCCEEEECCCCCCHHEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCC
GVKPGDKVYRSGAPLSVELGPGLIGKIYDGLQRPLDSIAKVSNSPFVARGVSIPALDRQT
CCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
KWHFVPKVKSGDKVGPGDIIGVVQETDLIEHRILIPPNVHGTLKELAREGDYTVEDVVAV
CEEECCCCCCCCCCCCCCEEEEEECCCHHHCEEECCCCCCHHHHHHHHCCCCCHHHEEEE
VDMNGDEIPVKMYQKWPVRIPRPYKEKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFG
EECCCCCCCHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGKTVTLQSLAKWSAAKVVIYVGCGERGNEMTDELRSFPKLKDPWTGKPLLLRTILVANT
CCCEEEHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
SNMPVAARESSIYVGVTMAEYFRDQGYDVLLVADSTSRWAEALRDLGGRMEEMPAEEGFP
CCCCEEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCCH
SYLPSRLAEYYERAGRVIALGNPERYGSVTIASAVSPPGGDFTEPVTSNTLRFVRVFWPL
HHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
DVSLAQARHYPAINWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVR
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHH
LVGPESLAEKDKLVLEAAKLIKDAFLKQNAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDL
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCHHH
ISKGVPLKKILDKVGPIEPEIIRIKYTIKNDELNKIDEIENKLKATFDSLLKEVS
HHCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNMVSEGRVVRVNGPLVIADGMREAQMFEVVYVSDLKLVGEITRIEGDRAFIQVYESTD
CCCCCCCEEEEECCCEEEECCCCCCHHEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCC
GVKPGDKVYRSGAPLSVELGPGLIGKIYDGLQRPLDSIAKVSNSPFVARGVSIPALDRQT
CCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
KWHFVPKVKSGDKVGPGDIIGVVQETDLIEHRILIPPNVHGTLKELAREGDYTVEDVVAV
CEEECCCCCCCCCCCCCCEEEEEECCCHHHCEEECCCCCCHHHHHHHHCCCCCHHHEEEE
VDMNGDEIPVKMYQKWPVRIPRPYKEKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFG
EECCCCCCCHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGKTVTLQSLAKWSAAKVVIYVGCGERGNEMTDELRSFPKLKDPWTGKPLLLRTILVANT
CCCEEEHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
SNMPVAARESSIYVGVTMAEYFRDQGYDVLLVADSTSRWAEALRDLGGRMEEMPAEEGFP
CCCCEEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCCH
SYLPSRLAEYYERAGRVIALGNPERYGSVTIASAVSPPGGDFTEPVTSNTLRFVRVFWPL
HHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
DVSLAQARHYPAINWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVR
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHH
LVGPESLAEKDKLVLEAAKLIKDAFLKQNAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDL
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCHHH
ISKGVPLKKILDKVGPIEPEIIRIKYTIKNDELNKIDEIENKLKATFDSLLKEVS
HHCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2896191; 11572479 [H]