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The map label for this gene is map [H]

Identifier: 15921708

GI number: 15921708

Start: 1421745

End: 1422638

Strand: Direct

Name: map [H]

Synonym: ST1419

Alternate gene names: 15921708

Gene position: 1421745-1422638 (Clockwise)

Preceding gene: 15921706

Following gene: 15921709

Centisome position: 52.76

GC content: 33.67

Gene sequence:

>894_bases
GTGGAAGAATCAGATTTAGAATTATTAAGAAAAGCAGGCAAGATAGCTGCAAAGGCTAGGGATTATGGTGCTAAGCTGAT
AAAACCTGGAGCTAAAGTTTATGATATTTGTGAAACAGTAGAAAAGATAATAATAGAAGAGGGAGCTAAACCAGCGTTTC
CTTGCAATCTGTCTATAAATTCTGAAGCAGCTCATTATAGCCCATTAATAGATGATGAAAAAACTATTCCAGAAGGTGCG
GTAGTAAAATTAGATATAGGTGCTCATATTGATGGTTATATTACCGATACGGCAGTTACAGTAGTATTAGACGATAAATA
CCAAAAACTTGCTGAAGCAGCAAAAGATGCACTCAACGCTGCTATAGCTAACTTTAAACCCGGTACTGATTTAGGAGAGA
TTGGAAAAAACATAGAAAAAATAATAAAGATCCATGGTTTCAAACCTATAAGGAATTTAGGAGGCCATTTGATAAGACGA
TATGAACTTCATGCTGGAGTGTTTGTACCAAACATTTATGAAAGAGGCCTTGGAAGAATTATTGAAGGTAATACATATGC
TATAGAACCATTTGCAACAAATGGGGAAGGAGAGGTTATTGAAGGTAAAGATATTACTATTTATTCAATTAAAACATTAA
ATGCTAAAGGACTTACTGATGAAGAAAAAAGATTCCTAGCTCAAATATATAAAAAAGCAAATATGCTACCATTCAATGAA
AGATGGTTAAGAGATCTAGGAGAACCTAATTACATAAGACAAATGTTAAAAACTTTAGTAAGAAGGGGTGCATTAAGGGC
GTATCCAATTTTAATAGAAGTAAGAAAAGGATTAGTTTCTCAGTTTGAGCACACGGTACTAGTTACTAGAGATGGTGCTG
AAATTATAACTTAA

Upstream 100 bases:

>100_bases
AGATTTAATTCAACTGCTGCGTGACCTAGCCATCTTAATTGTGGCATATACAAAGTTATTTTAAAGGAAAAAATTAAAGT
TTCTATTCCTTTGTTACAGT

Downstream 100 bases:

>100_bases
CAAGATTAACATTTTGTTGCAAATGATCTAATCTAAACTCATGGAAACATCTTATTTAATGTTATTACTTTCTGTAGAAA
CATAACCATTTATAAATAGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MEESDLELLRKAGKIAAKARDYGAKLIKPGAKVYDICETVEKIIIEEGAKPAFPCNLSINSEAAHYSPLIDDEKTIPEGA
VVKLDIGAHIDGYITDTAVTVVLDDKYQKLAEAAKDALNAAIANFKPGTDLGEIGKNIEKIIKIHGFKPIRNLGGHLIRR
YELHAGVFVPNIYERGLGRIIEGNTYAIEPFATNGEGEVIEGKDITIYSIKTLNAKGLTDEEKRFLAQIYKKANMLPFNE
RWLRDLGEPNYIRQMLKTLVRRGALRAYPILIEVRKGLVSQFEHTVLVTRDGAEIIT

Sequences:

>Translated_297_residues
MEESDLELLRKAGKIAAKARDYGAKLIKPGAKVYDICETVEKIIIEEGAKPAFPCNLSINSEAAHYSPLIDDEKTIPEGA
VVKLDIGAHIDGYITDTAVTVVLDDKYQKLAEAAKDALNAAIANFKPGTDLGEIGKNIEKIIKIHGFKPIRNLGGHLIRR
YELHAGVFVPNIYERGLGRIIEGNTYAIEPFATNGEGEVIEGKDITIYSIKTLNAKGLTDEEKRFLAQIYKKANMLPFNE
RWLRDLGEPNYIRQMLKTLVRRGALRAYPILIEVRKGLVSQFEHTVLVTRDGAEIIT
>Mature_297_residues
MEESDLELLRKAGKIAAKARDYGAKLIKPGAKVYDICETVEKIIIEEGAKPAFPCNLSINSEAAHYSPLIDDEKTIPEGA
VVKLDIGAHIDGYITDTAVTVVLDDKYQKLAEAAKDALNAAIANFKPGTDLGEIGKNIEKIIKIHGFKPIRNLGGHLIRR
YELHAGVFVPNIYERGLGRIIEGNTYAIEPFATNGEGEVIEGKDITIYSIKTLNAKGLTDEEKRFLAQIYKKANMLPFNE
RWLRDLGEPNYIRQMLKTLVRRGALRAYPILIEVRKGLVSQFEHTVLVTRDGAEIIT

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=307, Percent_Identity=34.5276872964169, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI124494254, Length=291, Percent_Identity=25.7731958762887, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI164420681, Length=309, Percent_Identity=25.8899676375405, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786364, Length=214, Percent_Identity=28.0373831775701, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17544396, Length=311, Percent_Identity=33.7620578778135, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17542840, Length=297, Percent_Identity=31.3131313131313, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996291, Length=208, Percent_Identity=27.8846153846154, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319380, Length=313, Percent_Identity=31.3099041533546, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323273, Length=302, Percent_Identity=25.4966887417219, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137568, Length=307, Percent_Identity=33.8762214983713, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24658585, Length=314, Percent_Identity=27.3885350318471, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355531, Length=207, Percent_Identity=27.0531400966184, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583427, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 33000; Mature: 33000

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS01202 MAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESDLELLRKAGKIAAKARDYGAKLIKPGAKVYDICETVEKIIIEEGAKPAFPCNLSIN
CCCHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
SEAAHYSPLIDDEKTIPEGAVVKLDIGAHIDGYITDTAVTVVLDDKYQKLAEAAKDALNA
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEECEEEEEEECHHHHHHHHHHHHHHHH
AIANFKPGTDLGEIGKNIEKIIKIHGFKPIRNLGGHLIRRYELHAGVFVPNIYERGLGRI
HHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEE
IEGNTYAIEPFATNGEGEVIEGKDITIYSIKTLNAKGLTDEEKRFLAQIYKKANMLPFNE
ECCCEEEEEEEEECCCCCEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCH
RWLRDLGEPNYIRQMLKTLVRRGALRAYPILIEVRKGLVSQFEHTVLVTRDGAEIIT
HHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCHHCC
>Mature Secondary Structure
MEESDLELLRKAGKIAAKARDYGAKLIKPGAKVYDICETVEKIIIEEGAKPAFPCNLSIN
CCCHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
SEAAHYSPLIDDEKTIPEGAVVKLDIGAHIDGYITDTAVTVVLDDKYQKLAEAAKDALNA
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEECEEEEEEECHHHHHHHHHHHHHHHH
AIANFKPGTDLGEIGKNIEKIIKIHGFKPIRNLGGHLIRRYELHAGVFVPNIYERGLGRI
HHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEE
IEGNTYAIEPFATNGEGEVIEGKDITIYSIKTLNAKGLTDEEKRFLAQIYKKANMLPFNE
ECCCEEEEEEEEECCCCCEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCH
RWLRDLGEPNYIRQMLKTLVRRGALRAYPILIEVRKGLVSQFEHTVLVTRDGAEIIT
HHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]