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The map label for this gene is merA [H]

Identifier: 15921327

GI number: 15921327

Start: 1059125

End: 1060495

Strand: Reverse

Name: merA [H]

Synonym: ST1075

Alternate gene names: 15921327

Gene position: 1060495-1059125 (Counterclockwise)

Preceding gene: 15921330

Following gene: 15921325

Centisome position: 39.35

GC content: 36.18

Gene sequence:

>1371_bases
GTGACTGAAATGAGATTGGTAATTGTAGGTAATGGGGCAGCAGCATTTGCAGCATTAATAAGGGCTAACGAACTTGGAGT
TAAACCAGTAATGATTAGTCACGGAATTATAGGTGGAACTTGCGTTAATGTAGGTTGTGTGCCCTCAAAAAGAATGTTAA
GAATAGGTGAAGTTTACGATTACACAAGAAAAACTTTAGGAAAAGATGTATACCCAGATTTTTTCAAAGCATTTGAAGAT
AAACAAGAAATAGTTGAGACTTTAAGAAAAGAAAAATATATAGATGTTTTATCCTCATATGACGTAGAATATGTGGAGGG
AAAAGCACACTTTGTCTCCCCTAAGGAAGTAAAGGTTAATGGTAAAATAATTGAGGGAGATAAGTTCATAATTGCGACGG
GTTCTTCTCCTCAAATACCGGATATACCGGGGCTGAAAGAACTCGGTTATTGGACGAATGTAGAAGCTTTATCACCAAAC
AGAAAAATCTCCTCGCTGGCTGTTATTGGTGGAAGAGCTTTAGCATTAGAGTTTGCACAGATGTACAAAAGGCTAGGAGT
AGATGTTTTAATACTTCAAAGAAGTAAGATAATAATACCCAATTGGGAACCAGAAATTTCAATTGCAGTTCAAAACTACT
TGTCAAAAGAAGAGGGCATATATATTGTTACTGACGTTAAAATTAAAGAAATTAAAAAAGGAGATGAAGGAGGGAAAATA
ATAGTAACTGATAAAGGTGAAGCAGAAGTAGACGAAATTTTAGTTGCAACCGGAAGAAGACCTAATGTAGACTTAAACTT
AGATGTAGCGGGAGTAAAGCTAAACGAGAAAGGGGGAATATTAGTTAATGAAACACTTCAAACAACAAACCCCAATATCT
ACGCTGCTGGAGATGTAATCGGAGATTTAATGCTTGAATCTTTAGCCGGTAAAGAAGGTTCAGTAGCTGCTGAAAATGCT
ATATTAAACTCTGGTAAAAAGATAGACAGACTTAGTATACCACAAGTAATATTCATAGAACCTAACGTTGCAAGAGTAGG
GCTTACTTATCTCGAGGCACAGCGTGAATACTCAGTTGAATCAAGAGTAGTTAAGATGAGTAGTGTTGCTAAAGCCAGAA
TATTAAGGGAGCCCCAAGGATTAATAAAAATGAATGTGGATAAAAATACAAAGAAAATACTGGGAGTACAGATGTTTGGA
AAGTATGCTGCTGAAGTAATAAATGAGGCTGCATTAGCAATTAGATTAAGGGCAACGATAGACGATATAATAGATACTGT
TCACGTATTCCCTACAATGGCTGAAAGCTTAAAACTAGCTGCAATGTCGTTCTACAGAGATGTGGATAAAATGAGCTGTT
GTGTTGACTAA

Upstream 100 bases:

>100_bases
AACTAACAGAAGACAATATTTATGTTAGAGTAATAAATGGCAAAGAACATTATTTCTGTTGTTCACATTGTGCTGATAAA
TATGAACAGAGGATTAAAAT

Downstream 100 bases:

>100_bases
GGAAAAATTTTAATTAATTTTAAAACATTTATGAGAATACTATCTCATGAATAATATATTTCTTATCAAGACTTTTATAT
TAGTAATTAGAATAATATAT

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTEMRLVIVGNGAAAFAALIRANELGVKPVMISHGIIGGTCVNVGCVPSKRMLRIGEVYDYTRKTLGKDVYPDFFKAFED
KQEIVETLRKEKYIDVLSSYDVEYVEGKAHFVSPKEVKVNGKIIEGDKFIIATGSSPQIPDIPGLKELGYWTNVEALSPN
RKISSLAVIGGRALALEFAQMYKRLGVDVLILQRSKIIIPNWEPEISIAVQNYLSKEEGIYIVTDVKIKEIKKGDEGGKI
IVTDKGEAEVDEILVATGRRPNVDLNLDVAGVKLNEKGGILVNETLQTTNPNIYAAGDVIGDLMLESLAGKEGSVAAENA
ILNSGKKIDRLSIPQVIFIEPNVARVGLTYLEAQREYSVESRVVKMSSVAKARILREPQGLIKMNVDKNTKKILGVQMFG
KYAAEVINEAALAIRLRATIDDIIDTVHVFPTMAESLKLAAMSFYRDVDKMSCCVD

Sequences:

>Translated_456_residues
MTEMRLVIVGNGAAAFAALIRANELGVKPVMISHGIIGGTCVNVGCVPSKRMLRIGEVYDYTRKTLGKDVYPDFFKAFED
KQEIVETLRKEKYIDVLSSYDVEYVEGKAHFVSPKEVKVNGKIIEGDKFIIATGSSPQIPDIPGLKELGYWTNVEALSPN
RKISSLAVIGGRALALEFAQMYKRLGVDVLILQRSKIIIPNWEPEISIAVQNYLSKEEGIYIVTDVKIKEIKKGDEGGKI
IVTDKGEAEVDEILVATGRRPNVDLNLDVAGVKLNEKGGILVNETLQTTNPNIYAAGDVIGDLMLESLAGKEGSVAAENA
ILNSGKKIDRLSIPQVIFIEPNVARVGLTYLEAQREYSVESRVVKMSSVAKARILREPQGLIKMNVDKNTKKILGVQMFG
KYAAEVINEAALAIRLRATIDDIIDTVHVFPTMAESLKLAAMSFYRDVDKMSCCVD
>Mature_455_residues
TEMRLVIVGNGAAAFAALIRANELGVKPVMISHGIIGGTCVNVGCVPSKRMLRIGEVYDYTRKTLGKDVYPDFFKAFEDK
QEIVETLRKEKYIDVLSSYDVEYVEGKAHFVSPKEVKVNGKIIEGDKFIIATGSSPQIPDIPGLKELGYWTNVEALSPNR
KISSLAVIGGRALALEFAQMYKRLGVDVLILQRSKIIIPNWEPEISIAVQNYLSKEEGIYIVTDVKIKEIKKGDEGGKII
VTDKGEAEVDEILVATGRRPNVDLNLDVAGVKLNEKGGILVNETLQTTNPNIYAAGDVIGDLMLESLAGKEGSVAAENAI
LNSGKKIDRLSIPQVIFIEPNVARVGLTYLEAQREYSVESRVVKMSSVAKARILREPQGLIKMNVDKNTKKILGVQMFGK
YAAEVINEAALAIRLRATIDDIIDTVHVFPTMAESLKLAAMSFYRDVDKMSCCVD

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=31.5789473684211, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI50301238, Length=450, Percent_Identity=28.6666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI33519430, Length=433, Percent_Identity=27.0207852193995, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI33519428, Length=433, Percent_Identity=27.0207852193995, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI33519426, Length=433, Percent_Identity=27.0207852193995, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148277071, Length=433, Percent_Identity=27.0207852193995, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148277065, Length=433, Percent_Identity=27.0207852193995, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI22035672, Length=447, Percent_Identity=28.1879194630872, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=26.9585253456221, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI291045268, Length=423, Percent_Identity=27.1867612293144, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=31.4775160599572, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=27.7777777777778, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=32.3462414578588, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=24.4493392070485, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789065, Length=189, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=30.1724137931034, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71983419, Length=434, Percent_Identity=30.184331797235, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=434, Percent_Identity=30.184331797235, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17557007, Length=489, Percent_Identity=26.3803680981595, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=438, Percent_Identity=24.2009132420091, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321091, Length=490, Percent_Identity=30, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=448, Percent_Identity=26.5625, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=25.2653927813163, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21358499, Length=477, Percent_Identity=30.398322851153, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=29.0123456790123, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640553, Length=486, Percent_Identity=29.0123456790123, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24640551, Length=486, Percent_Identity=29.0123456790123, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17737741, Length=493, Percent_Identity=27.1805273833671, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 50082; Mature: 49951

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMRLVIVGNGAAAFAALIRANELGVKPVMISHGIIGGTCVNVGCVPSKRMLRIGEVYD
CCCEEEEEEECCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHH
YTRKTLGKDVYPDFFKAFEDKQEIVETLRKEKYIDVLSSYDVEYVEGKAHFVSPKEVKVN
HHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCEEEEC
GKIIEGDKFIIATGSSPQIPDIPGLKELGYWTNVEALSPNRKISSLAVIGGRALALEFAQ
CEEEECCEEEEEECCCCCCCCCCCHHHCCCCCCEEECCCCCCCCEEEEECCHHHHHHHHH
MYKRLGVDVLILQRSKIIIPNWEPEISIAVQNYLSKEEGIYIVTDVKIKEIKKGDEGGKI
HHHHCCCEEEEEECCEEEECCCCCCEEEEEHHHCCCCCCEEEEECCEEEHHHCCCCCCEE
IVTDKGEAEVDEILVATGRRPNVDLNLDVAGVKLNEKGGILVNETLQTTNPNIYAAGDVI
EEECCCCCCHHHHHEECCCCCCCEEEEEEEEEEECCCCCEEEECEEECCCCCEEECHHHH
GDLMLESLAGKEGSVAAENAILNSGKKIDRLSIPQVIFIEPNVARVGLTYLEAQREYSVE
HHHHHHHHCCCCCCCHHHHHHHCCCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHCCHH
SRVVKMSSVAKARILREPQGLIKMNVDKNTKKILGVQMFGKYAAEVINEAALAIRLRATI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
DDIIDTVHVFPTMAESLKLAAMSFYRDVDKMSCCVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEMRLVIVGNGAAAFAALIRANELGVKPVMISHGIIGGTCVNVGCVPSKRMLRIGEVYD
CCEEEEEEECCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHH
YTRKTLGKDVYPDFFKAFEDKQEIVETLRKEKYIDVLSSYDVEYVEGKAHFVSPKEVKVN
HHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCEEEEC
GKIIEGDKFIIATGSSPQIPDIPGLKELGYWTNVEALSPNRKISSLAVIGGRALALEFAQ
CEEEECCEEEEEECCCCCCCCCCCHHHCCCCCCEEECCCCCCCCEEEEECCHHHHHHHHH
MYKRLGVDVLILQRSKIIIPNWEPEISIAVQNYLSKEEGIYIVTDVKIKEIKKGDEGGKI
HHHHCCCEEEEEECCEEEECCCCCCEEEEEHHHCCCCCCEEEEECCEEEHHHCCCCCCEE
IVTDKGEAEVDEILVATGRRPNVDLNLDVAGVKLNEKGGILVNETLQTTNPNIYAAGDVI
EEECCCCCCHHHHHEECCCCCCCEEEEEEEEEEECCCCCEEEECEEECCCCCEEECHHHH
GDLMLESLAGKEGSVAAENAILNSGKKIDRLSIPQVIFIEPNVARVGLTYLEAQREYSVE
HHHHHHHHCCCCCCCHHHHHHHCCCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHCCHH
SRVVKMSSVAKARILREPQGLIKMNVDKNTKKILGVQMFGKYAAEVINEAALAIRLRATI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
DDIIDTVHVFPTMAESLKLAAMSFYRDVDKMSCCVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]