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The map label for this gene is mtaP [H]

Identifier: 15921217

GI number: 15921217

Start: 953437

End: 954150

Strand: Direct

Name: mtaP [H]

Synonym: ST0975

Alternate gene names: 15921217

Gene position: 953437-954150 (Clockwise)

Preceding gene: 15921216

Following gene: 15921218

Centisome position: 35.38

GC content: 35.01

Gene sequence:

>714_bases
GTGAACCCAGTTCACATACTTGCCAAGAAAGGGGATATAGCTGAAAAAGTTATTATAGCTGGCGATCCTAGCAGAGTCAA
GAGCCTTTCTAAATTTTTAGAGGAACCTCAACTTGTAAATGAAAATAGAGGTTTTTTAATCTACACCGGTAAGTACAAGG
GAGAAAGAATAAGTATAGCTACTCATGGAATTGGTGGTCCATCAATAGCAATAGTTTTAGAAGAATTAACTATGTTAGGA
GGGAGGATATTTATCAGATACGGTACATCTGGTGCTTTAGTTCCAGAGGTTAATATTGGAGATTATGTTATAGTTACTGG
TGCTTCCTATAATCCTTCAAGCTTAGTTTACCAATACTTTAAAGAACAAGCTTGTGTTTCAGCTACTCCAGATTTCGAAA
TAACCATGGCTTTATACAACTCTTTTAAGAACAAGGGGTTAAAGTTCCATTTAGGTAATGTATTTAGTAGTGATGCTTTT
TACGCTGAAGATGAAGACTTTGCAAAGAAATGGTCAGAGAGAGGAAATATAGCCGTTGAAATGGAGTGTGCTACCTTATT
TATGTTAAGTAAATTAAGGAAAATTAGGAGTGGCGCCGTAGTTATAATCAGTGATAGTTTAGTCAAAGGAGGATGGATTA
GTAAAGATGAATTGGAGAAGAAAGTTAGTGATGGTGCAATAGCTATTTTAGATGCCTTAATTAATATAACTTAA

Upstream 100 bases:

>100_bases
TTTCTAACATTTTAATATTACTGTTTATACTTGTTAAGTAGATGATGAGCGCCGGCTGTAATGATTAATGATATAAAATT
TCTTGGCTGATATATTTTCT

Downstream 100 bases:

>100_bases
TATGAAGATTATAAGAGATCCTATACACGGTTACATAGAAGTTCCAGATGATATCTTACCAGTAATTTCTTCTCCCTTTT
TTCAGCGATTAAGGTTTATT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNPVHILAKKGDIAEKVIIAGDPSRVKSLSKFLEEPQLVNENRGFLIYTGKYKGERISIATHGIGGPSIAIVLEELTMLG
GRIFIRYGTSGALVPEVNIGDYVIVTGASYNPSSLVYQYFKEQACVSATPDFEITMALYNSFKNKGLKFHLGNVFSSDAF
YAEDEDFAKKWSERGNIAVEMECATLFMLSKLRKIRSGAVVIISDSLVKGGWISKDELEKKVSDGAIAILDALINIT

Sequences:

>Translated_237_residues
MNPVHILAKKGDIAEKVIIAGDPSRVKSLSKFLEEPQLVNENRGFLIYTGKYKGERISIATHGIGGPSIAIVLEELTMLG
GRIFIRYGTSGALVPEVNIGDYVIVTGASYNPSSLVYQYFKEQACVSATPDFEITMALYNSFKNKGLKFHLGNVFSSDAF
YAEDEDFAKKWSERGNIAVEMECATLFMLSKLRKIRSGAVVIISDSLVKGGWISKDELEKKVSDGAIAILDALINIT
>Mature_237_residues
MNPVHILAKKGDIAEKVIIAGDPSRVKSLSKFLEEPQLVNENRGFLIYTGKYKGERISIATHGIGGPSIAIVLEELTMLG
GRIFIRYGTSGALVPEVNIGDYVIVTGASYNPSSLVYQYFKEQACVSATPDFEITMALYNSFKNKGLKFHLGNVFSSDAF
YAEDEDFAKKWSERGNIAVEMECATLFMLSKLRKIRSGAVVIISDSLVKGGWISKDELEKKVSDGAIAILDALINIT

Specific function: Endowed with a broad substrate specificity, being able to phosphorolytically cleave inosine, guanosine, and adenosine with a better efficiency than MTA [H]

COG id: COG2820

COG function: function code F; Uridine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family [H]

Homologues:

Organism=Escherichia coli, GI1790844, Length=209, Percent_Identity=35.4066985645933, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790265, Length=214, Percent_Identity=33.6448598130841, Blast_Score=117, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018017
- InterPro:   IPR018016
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 25967; Mature: 25967

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01232 PNP_UDP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVHILAKKGDIAEKVIIAGDPSRVKSLSKFLEEPQLVNENRGFLIYTGKYKGERISIA
CCCEEEEEECCCCCCEEEEECCHHHHHHHHHHHCCCCEECCCCCEEEEECCCCCCEEEEE
THGIGGPSIAIVLEELTMLGGRIFIRYGTSGALVPEVNIGDYVIVTGASYNPSSLVYQYF
ECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
KEQACVSATPDFEITMALYNSFKNKGLKFHLGNVFSSDAFYAEDEDFAKKWSERGNIAVE
HHHHHCCCCCCCEEHHHHHHHHHHCCEEEEECCEECCCCCCCCCHHHHHHHHHCCCEEEE
MECATLFMLSKLRKIRSGAVVIISDSLVKGGWISKDELEKKVSDGAIAILDALINIT
EHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNPVHILAKKGDIAEKVIIAGDPSRVKSLSKFLEEPQLVNENRGFLIYTGKYKGERISIA
CCCEEEEEECCCCCCEEEEECCHHHHHHHHHHHCCCCEECCCCCEEEEECCCCCCEEEEE
THGIGGPSIAIVLEELTMLGGRIFIRYGTSGALVPEVNIGDYVIVTGASYNPSSLVYQYF
ECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
KEQACVSATPDFEITMALYNSFKNKGLKFHLGNVFSSDAFYAEDEDFAKKWSERGNIAVE
HHHHHCCCCCCCEEHHHHHHHHHHCCEEEEECCEECCCCCCCCCHHHHHHHHHCCCEEEE
MECATLFMLSKLRKIRSGAVVIISDSLVKGGWISKDELEKKVSDGAIAILDALINIT
EHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726; 7929153 [H]