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The map label for this gene is glgC [C]

Identifier: 15921209

GI number: 15921209

Start: 943087

End: 943773

Strand: Direct

Name: glgC [C]

Synonym: ST0968

Alternate gene names: 15921209

Gene position: 943087-943773 (Clockwise)

Preceding gene: 15921208

Following gene: 15921211

Centisome position: 35.0

GC content: 31.44

Gene sequence:

>687_bases
ATGAAAGCTGTAATTTTAGCTGGAGGTTACGGTAAAAGATTAAGACCTTTAACTGATGATAAACCTAAACCCCTAGTAGA
AGTTGCTGGAAAACCTATTATAGAATGGCAAATACATTGGTTAAAGAGTTTTGGTATTACTTCTTTCTTTGTGTTAGCTG
GTTACAAAAAAGAAGCTCTCATTGAATGGATTTCAAAAAATCAACAAAGACTTAATGTGTCAATTGCTACATTAACAGAA
GAAGAACCATTAGGTACCGGTGGTGCAATAAGAAGACTTAAAGATTTCATAAGTGATGATTTCATAGTTATAAATGGAGA
TATACTTACTAACATTGATATTAACAAGATGGTGTTAAAAGATTGTATTGTAGCTATAGCTCTAGTTCCTTTAAGGAGCC
CATATGGTATTGTAAGTATAGATGACAATGGAAAAATAATACGTTTTGTCGAAAAACCCTTATTAAAAGAATACTGGATA
AATGCTGGTGTTTACAAAATGAAACCAGAGGTTTTTGAATATTTACCGGAAAAAGGAGATATTGAAAAAATAACGTTTCC
GTCTCTAGCTGAAAAAGGTTTACTTAAAGGAGTAACTTATGAAAACGTTTACTGGAGATCAATAGATACTATAAAAGATT
ATGAAGAAGCATCAGTAGAGATACCGGAAGTATTTAAGAAGTTATGA

Upstream 100 bases:

>100_bases
AGGAATAGATGTGGCTAAATTCATAGAAAAATAATAAGAAAAAAGAGAATATTAGAGGACTCTGAAAAACTTTATTATTA
TAAAGAATTGTAGTAATTTA

Downstream 100 bases:

>100_bases
TTTCCACATCATTATCACTATTTAACCATTTTTGTAAAGCTCCTTCAAGCCCTAGATCTCTTACATCCTTCATAAATTTC
CTCCTTAAATCTGCTATTAA

Product: GDP-mannose pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKAVILAGGYGKRLRPLTDDKPKPLVEVAGKPIIEWQIHWLKSFGITSFFVLAGYKKEALIEWISKNQQRLNVSIATLTE
EEPLGTGGAIRRLKDFISDDFIVINGDILTNIDINKMVLKDCIVAIALVPLRSPYGIVSIDDNGKIIRFVEKPLLKEYWI
NAGVYKMKPEVFEYLPEKGDIEKITFPSLAEKGLLKGVTYENVYWRSIDTIKDYEEASVEIPEVFKKL

Sequences:

>Translated_228_residues
MKAVILAGGYGKRLRPLTDDKPKPLVEVAGKPIIEWQIHWLKSFGITSFFVLAGYKKEALIEWISKNQQRLNVSIATLTE
EEPLGTGGAIRRLKDFISDDFIVINGDILTNIDINKMVLKDCIVAIALVPLRSPYGIVSIDDNGKIIRFVEKPLLKEYWI
NAGVYKMKPEVFEYLPEKGDIEKITFPSLAEKGLLKGVTYENVYWRSIDTIKDYEEASVEIPEVFKKL
>Mature_228_residues
MKAVILAGGYGKRLRPLTDDKPKPLVEVAGKPIIEWQIHWLKSFGITSFFVLAGYKKEALIEWISKNQQRLNVSIATLTE
EEPLGTGGAIRRLKDFISDDFIVINGDILTNIDINKMVLKDCIVAIALVPLRSPYGIVSIDDNGKIIRFVEKPLLKEYWI
NAGVYKMKPEVFEYLPEKGDIEKITFPSLAEKGLLKGVTYENVYWRSIDTIKDYEEASVEIPEVFKKL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=36.283185840708, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=36.283185840708, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI31881779, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI45447090, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1789837, Length=276, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=227, Percent_Identity=37.4449339207048, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17509979, Length=249, Percent_Identity=31.7269076305221, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17509981, Length=235, Percent_Identity=30.6382978723404, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320148, Length=234, Percent_Identity=36.3247863247863, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320417, Length=123, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355443, Length=226, Percent_Identity=34.070796460177, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644084, Length=226, Percent_Identity=34.070796460177, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653912, Length=199, Percent_Identity=31.1557788944724, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 25891; Mature: 25891

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILAGGYGKRLRPLTDDKPKPLVEVAGKPIIEWQIHWLKSFGITSFFVLAGYKKEAL
CCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHCCHHHEEEHHCCCHHHH
IEWISKNQQRLNVSIATLTEEEPLGTGGAIRRLKDFISDDFIVINGDILTNIDINKMVLK
HHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCEEECCCHHHHHHH
DCIVAIALVPLRSPYGIVSIDDNGKIIRFVEKPLLKEYWINAGVYKMKPEVFEYLPEKGD
HHHHHHHHHHCCCCCEEEEECCCCCEEEEHHHHHHHHHHCCCCEEEECHHHHHHCCCCCC
IEKITFPSLAEKGLLKGVTYENVYWRSIDTIKDYEEASVEIPEVFKKL
CCEEECHHHHHHHHHCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MKAVILAGGYGKRLRPLTDDKPKPLVEVAGKPIIEWQIHWLKSFGITSFFVLAGYKKEAL
CCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHCCHHHEEEHHCCCHHHH
IEWISKNQQRLNVSIATLTEEEPLGTGGAIRRLKDFISDDFIVINGDILTNIDINKMVLK
HHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCEEECCCHHHHHHH
DCIVAIALVPLRSPYGIVSIDDNGKIIRFVEKPLLKEYWINAGVYKMKPEVFEYLPEKGD
HHHHHHHHHHCCCCCEEEEECCCCCEEEEHHHHHHHHHHCCCCEEEECHHHHHHCCCCCC
IEKITFPSLAEKGLLKGVTYENVYWRSIDTIKDYEEASVEIPEVFKKL
CCEEECHHHHHHHHHCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA