Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 15921207

GI number: 15921207

Start: 940931

End: 942553

Strand: Direct

Name: thrS

Synonym: ST0966

Alternate gene names: 15921207

Gene position: 940931-942553 (Clockwise)

Preceding gene: 15921202

Following gene: 15921208

Centisome position: 34.92

GC content: 32.84

Gene sequence:

>1623_bases
ATGGAAGAGTATAAAGGAGTATGGCTGAAGGCTGGTATAATCTATGCCTTAAATTTGGCCTCAAACGGGTTTAAACCCGT
AGAAGTCGGTTTAGGTGAGAGAGATTTTTATGTTGATGTAGAAAGTGATACTACCTTAACATTAGATGAAGCTAAGAAAT
TTGCTACTTACAATCAATACTCCTATCAGTTAAAGGATGGATATATAGAATTTAATGGAAATAAGATTAAGGTATTAGGA
GAGCCATCAAGCTTAGAACCAAAATATTTTGAAATACTTAATATTTCAGTTCATCATCCTTCTCCTAATGTTCAATACGT
TAGAATAAGAGGCGTAGGATTTGAGAAAAAAGAGGAATTAGATCAATATTTAAAGTGGCTAGAAGAGGTATCAGAATACG
ATCACAGAATAATAGGAGAAAGACTGGATTTGTTTAGTTTTCCGGACGAGACTGCACCAGGTCTTGCTCTATTTCATTAT
AAAGGGCAAATAATAAGAAAAGAGTTGATGAAGTTTATGGAAGAAATAAATGAAAGTATGGGTTACCAAGAAGTATTTAC
AGCAGAGATATATAGATCAATTCTCTGGAAAACTAGTGGTCATTACGACTATTATAAGGATAAGATGGTTCTTTTTAAGA
TGGAGGATGAAGAACTAGGGCTTAAGCCAATGAATTGTCCAGCTCATATCTTAATATATAAATCTAAAACGAGAAGTTAT
AAAGATTTACCTATAAGGTTTTCAGAGTTTGGATTGGTTTTTAGGTGGGAGAAAAGAGGTGAGCTTTATGGATTACTAAG
AGTTAGAGGATTTGTACAAGATGATGGGCATATATTCTTAACTGAAGATCAAATCAAAGATGAAGTAAAAATGTTAGTAA
AGAAAACTATTGATGTTTTATCTATTTTTGGTTTTAAAGGTGATGATGTTAGGATTAACCTAAGTACAAGACCAGATGAA
AGTATAGGAAGTGATGAATTATGGGAAAAGGCTACAAATGCTTTAGTTTCTGCCCTAAATGAGCTTGGGATAAAGTATAT
TGTGAAAGAAAAGGAAGGAGCATTTTATGGTCCTAAAATAGATTTCGATATAAGAGATAGTTTAGGTAGATGGTGGCAAT
TATCAACAATTCAAGTAGATTTCAATCTCCCAGAGAGATTTAAGTTAGAATATATAGACAAAGATGGGAGTAGAAAAAGA
CCAGTTATGATACATAGAGCTATTTATGGTTCCATAGAAAGATTTATGGCAATTCTATTAGAACATTTCAGAGGAAAATT
ACCTACGTGGCTCTCACCAGTTCAAGTTAGAATATTACCAATAAGTAAGGATGTGGAAGATTATGCCTTAAATCTACTCT
CTAAGCTAAAGGAAAATAAGATAAGAGTAGAACTAGATATGTCTGATGAGACTTTATCAAAAAGGATTAAGAAGGCTTAT
GATGAAGGTGTTCCCTACATGATAATAGTAGGAAAGAAGGAGAGAGAAGAGGGTAAAGTAACTGTAAGAGGTAGGAATAA
TGTGGAAATAAGGGGAGTTAAGTTTGATGACTTTCTCAAGGCATTATTAGAGGAGATAAGAAATAGAGATTTGAACCAGA
GTGCAATAAATAAATTAAAATGA

Upstream 100 bases:

>100_bases
GCTATTGCTCTTCCAAAACCAGTATGTCCTCCGCCACTTGCAATTATAAGTAATTCTGACACTAAAACTATTTTATTCGG
TTAGATAAAAATACCTAACT

Downstream 100 bases:

>100_bases
TAGTTTACGGTCTTTATAAAAGCCCTTTTGGTCCAATAACAGTAGCTAAAAATGAAAAAGGATTTGTTATGCTAGATTTT
TGTGATTGTGCAGAGAGGAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MEEYKGVWLKAGIIYALNLASNGFKPVEVGLGERDFYVDVESDTTLTLDEAKKFATYNQYSYQLKDGYIEFNGNKIKVLG
EPSSLEPKYFEILNISVHHPSPNVQYVRIRGVGFEKKEELDQYLKWLEEVSEYDHRIIGERLDLFSFPDETAPGLALFHY
KGQIIRKELMKFMEEINESMGYQEVFTAEIYRSILWKTSGHYDYYKDKMVLFKMEDEELGLKPMNCPAHILIYKSKTRSY
KDLPIRFSEFGLVFRWEKRGELYGLLRVRGFVQDDGHIFLTEDQIKDEVKMLVKKTIDVLSIFGFKGDDVRINLSTRPDE
SIGSDELWEKATNALVSALNELGIKYIVKEKEGAFYGPKIDFDIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGSRKR
PVMIHRAIYGSIERFMAILLEHFRGKLPTWLSPVQVRILPISKDVEDYALNLLSKLKENKIRVELDMSDETLSKRIKKAY
DEGVPYMIIVGKKEREEGKVTVRGRNNVEIRGVKFDDFLKALLEEIRNRDLNQSAINKLK

Sequences:

>Translated_540_residues
MEEYKGVWLKAGIIYALNLASNGFKPVEVGLGERDFYVDVESDTTLTLDEAKKFATYNQYSYQLKDGYIEFNGNKIKVLG
EPSSLEPKYFEILNISVHHPSPNVQYVRIRGVGFEKKEELDQYLKWLEEVSEYDHRIIGERLDLFSFPDETAPGLALFHY
KGQIIRKELMKFMEEINESMGYQEVFTAEIYRSILWKTSGHYDYYKDKMVLFKMEDEELGLKPMNCPAHILIYKSKTRSY
KDLPIRFSEFGLVFRWEKRGELYGLLRVRGFVQDDGHIFLTEDQIKDEVKMLVKKTIDVLSIFGFKGDDVRINLSTRPDE
SIGSDELWEKATNALVSALNELGIKYIVKEKEGAFYGPKIDFDIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGSRKR
PVMIHRAIYGSIERFMAILLEHFRGKLPTWLSPVQVRILPISKDVEDYALNLLSKLKENKIRVELDMSDETLSKRIKKAY
DEGVPYMIIVGKKEREEGKVTVRGRNNVEIRGVKFDDFLKALLEEIRNRDLNQSAINKLK
>Mature_540_residues
MEEYKGVWLKAGIIYALNLASNGFKPVEVGLGERDFYVDVESDTTLTLDEAKKFATYNQYSYQLKDGYIEFNGNKIKVLG
EPSSLEPKYFEILNISVHHPSPNVQYVRIRGVGFEKKEELDQYLKWLEEVSEYDHRIIGERLDLFSFPDETAPGLALFHY
KGQIIRKELMKFMEEINESMGYQEVFTAEIYRSILWKTSGHYDYYKDKMVLFKMEDEELGLKPMNCPAHILIYKSKTRSY
KDLPIRFSEFGLVFRWEKRGELYGLLRVRGFVQDDGHIFLTEDQIKDEVKMLVKKTIDVLSIFGFKGDDVRINLSTRPDE
SIGSDELWEKATNALVSALNELGIKYIVKEKEGAFYGPKIDFDIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGSRKR
PVMIHRAIYGSIERFMAILLEHFRGKLPTWLSPVQVRILPISKDVEDYALNLLSKLKENKIRVELDMSDETLSKRIKKAY
DEGVPYMIIVGKKEREEGKVTVRGRNNVEIRGVKFDDFLKALLEEIRNRDLNQSAINKLK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=402, Percent_Identity=42.5373134328358, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI38570111, Length=402, Percent_Identity=42.0398009950249, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI20070344, Length=447, Percent_Identity=36.6890380313199, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1788013, Length=433, Percent_Identity=44.5727482678984, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71984184, Length=411, Percent_Identity=41.8491484184915, Blast_Score=337, Evalue=8e-93,
Organism=Caenorhabditis elegans, GI71984192, Length=411, Percent_Identity=41.8491484184915, Blast_Score=337, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6322112, Length=453, Percent_Identity=41.0596026490066, Blast_Score=347, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=42, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24583839, Length=401, Percent_Identity=43.640897755611, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24583842, Length=401, Percent_Identity=43.640897755611, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI28574141, Length=401, Percent_Identity=43.640897755611, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_SULTO (Q973C8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376876.1
- ProteinModelPortal:   Q973C8
- SMR:   Q973C8
- GeneID:   1458938
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0966
- NMPDR:   fig|273063.1.peg.1044
- HOGENOM:   HBG352811
- OMA:   HQVATIQ
- ProtClustDB:   PRK14799
- BioCyc:   STOK273063:ST0966-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_A
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 63111; Mature: 63111

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEYKGVWLKAGIIYALNLASNGFKPVEVGLGERDFYVDVESDTTLTLDEAKKFATYNQY
CCCCCCEEEEECEEEEEEECCCCCEEEEECCCCCEEEEEECCCCEEEHHHHHHHHCCCCE
SYQLKDGYIEFNGNKIKVLGEPSSLEPKYFEILNISVHHPSPNVQYVRIRGVGFEKKEEL
EEEEECCEEEECCCEEEEEECCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCHHHHH
DQYLKWLEEVSEYDHRIIGERLDLFSFPDETAPGLALFHYKGQIIRKELMKFMEEINESM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
GYQEVFTAEIYRSILWKTSGHYDYYKDKMVLFKMEDEELGLKPMNCPAHILIYKSKTRSY
CHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEECCHHCCCCCCCCCEEEEEEECCCCCC
KDLPIRFSEFGLVFRWEKRGELYGLLRVRGFVQDDGHIFLTEDQIKDEVKMLVKKTIDVL
CCCCEEEECCCEEEEEECCCCEEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHH
SIFGFKGDDVRINLSTRPDESIGSDELWEKATNALVSALNELGIKYIVKEKEGAFYGPKI
HHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEECCEE
DFDIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGSRKRPVMIHRAIYGSIERFMAILL
CEECHHCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHH
EHFRGKLPTWLSPVQVRILPISKDVEDYALNLLSKLKENKIRVELDMSDETLSKRIKKAY
HHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
DEGVPYMIIVGKKEREEGKVTVRGRNNVEIRGVKFDDFLKALLEEIRNRDLNQSAINKLK
HCCCCEEEEEECCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure
MEEYKGVWLKAGIIYALNLASNGFKPVEVGLGERDFYVDVESDTTLTLDEAKKFATYNQY
CCCCCCEEEEECEEEEEEECCCCCEEEEECCCCCEEEEEECCCCEEEHHHHHHHHCCCCE
SYQLKDGYIEFNGNKIKVLGEPSSLEPKYFEILNISVHHPSPNVQYVRIRGVGFEKKEEL
EEEEECCEEEECCCEEEEEECCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCHHHHH
DQYLKWLEEVSEYDHRIIGERLDLFSFPDETAPGLALFHYKGQIIRKELMKFMEEINESM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
GYQEVFTAEIYRSILWKTSGHYDYYKDKMVLFKMEDEELGLKPMNCPAHILIYKSKTRSY
CHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEECCHHCCCCCCCCCEEEEEEECCCCCC
KDLPIRFSEFGLVFRWEKRGELYGLLRVRGFVQDDGHIFLTEDQIKDEVKMLVKKTIDVL
CCCCEEEECCCEEEEEECCCCEEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHH
SIFGFKGDDVRINLSTRPDESIGSDELWEKATNALVSALNELGIKYIVKEKEGAFYGPKI
HHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEECCEE
DFDIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGSRKRPVMIHRAIYGSIERFMAILL
CEECHHCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHH
EHFRGKLPTWLSPVQVRILPISKDVEDYALNLLSKLKENKIRVELDMSDETLSKRIKKAY
HHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
DEGVPYMIIVGKKEREEGKVTVRGRNNVEIRGVKFDDFLKALLEEIRNRDLNQSAINKLK
HCCCCEEEEEECCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479