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The map label for this gene is ahpC [C]

Identifier: 15920801

GI number: 15920801

Start: 570524

End: 571171

Strand: Direct

Name: ahpC [C]

Synonym: ST0584

Alternate gene names: 15920801

Gene position: 570524-571171 (Clockwise)

Preceding gene: 15920800

Following gene: 15920803

Centisome position: 21.17

GC content: 35.65

Gene sequence:

>648_bases
ATGGTCAAACTATACTCTAAGTTCCCAGATGTTCAAGTATTAACAACAAAAGGTCCAATTGATTTCTACAAAGATATATT
TGGTAAAGGAAAATGGTTATTCCTATTCGCTCATCCAGCAGACTTTACACCAGTATGTACAACAGAATTTGTAGCATTCT
CGCAAAAGTATGAGGAATTCAAAAAACTTGGTGTAGAACTTGTTGGACTAAGTGTTGATAGTATTTACTCTCATATACAA
TGGTTAATGGATATTGAACAGAGATACGGCGTAAAAGTACCATTCCCAGTAATAGCAGACCCAGACAAGAAATTAGCAAG
GATGTTAGATGCATTAGATGAGGCCTCCGGTCAAACTATAAGAATTGTTGTTCTAGCATCACCGGATGGAATAATCAGAT
TTGTTGCTCAATATCCAATGGAGTTTGGAAGAAATATTGACGAATTGTTAAGAATAACTAAAGCTGCAATAGTTAACTAT
AAAGCAAAAGTAGTACTTCCAGCAAATTGGCAACCTGGTCAAGACGTTATAGTACCGCCACCAGCCATATTTGATGAAGC
AGAAATGAGAATCAAATTACCAAATGCAAAAGCATGGTACTTATTATTCAAGAAATATGAAGAACTTCCACCAGATCAGA
AAGTCTGA

Upstream 100 bases:

>100_bases
AACATCGATATTCGTCTTCTTAATATATAAACTCATCTATTAACTTTCATTTAAAAATAATTTAAAAACATGAAATGATA
CTAACTTATAGTGATTCTAA

Downstream 100 bases:

>100_bases
ATCAATACAATTTTTTTATTTGCCGGTAAAGCTACATTATAAACCCTCACGTTCCTGACCACGCTAAATGTTATTTTTGC
ATAATGTGCATGGCCATGTA

Product: putative peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MVKLYSKFPDVQVLTTKGPIDFYKDIFGKGKWLFLFAHPADFTPVCTTEFVAFSQKYEEFKKLGVELVGLSVDSIYSHIQ
WLMDIEQRYGVKVPFPVIADPDKKLARMLDALDEASGQTIRIVVLASPDGIIRFVAQYPMEFGRNIDELLRITKAAIVNY
KAKVVLPANWQPGQDVIVPPPAIFDEAEMRIKLPNAKAWYLLFKKYEELPPDQKV

Sequences:

>Translated_215_residues
MVKLYSKFPDVQVLTTKGPIDFYKDIFGKGKWLFLFAHPADFTPVCTTEFVAFSQKYEEFKKLGVELVGLSVDSIYSHIQ
WLMDIEQRYGVKVPFPVIADPDKKLARMLDALDEASGQTIRIVVLASPDGIIRFVAQYPMEFGRNIDELLRITKAAIVNY
KAKVVLPANWQPGQDVIVPPPAIFDEAEMRIKLPNAKAWYLLFKKYEELPPDQKV
>Mature_215_residues
MVKLYSKFPDVQVLTTKGPIDFYKDIFGKGKWLFLFAHPADFTPVCTTEFVAFSQKYEEFKKLGVELVGLSVDSIYSHIQ
WLMDIEQRYGVKVPFPVIADPDKKLARMLDALDEASGQTIRIVVLASPDGIIRFVAQYPMEFGRNIDELLRITKAAIVNY
KAKVVLPANWQPGQDVIVPPPAIFDEAEMRIKLPNAKAWYLLFKKYEELPPDQKV

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=36.8421052631579, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4505591, Length=152, Percent_Identity=36.8421052631579, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI32455266, Length=152, Percent_Identity=36.8421052631579, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI32455264, Length=152, Percent_Identity=36.8421052631579, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI5453549, Length=155, Percent_Identity=34.8387096774194, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI5802974, Length=159, Percent_Identity=37.7358490566038, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI32483377, Length=159, Percent_Identity=37.7358490566038, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI32189392, Length=152, Percent_Identity=36.1842105263158, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI33188454, Length=53, Percent_Identity=54.7169811320755, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786822, Length=152, Percent_Identity=34.8684210526316, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25153706, Length=161, Percent_Identity=38.5093167701863, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17554494, Length=159, Percent_Identity=37.7358490566038, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193204376, Length=152, Percent_Identity=36.1842105263158, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32565831, Length=152, Percent_Identity=36.1842105263158, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319407, Length=213, Percent_Identity=41.3145539906103, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323613, Length=153, Percent_Identity=36.6013071895425, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320661, Length=152, Percent_Identity=35.5263157894737, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24652436, Length=198, Percent_Identity=40.4040404040404, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24652434, Length=198, Percent_Identity=39.8989898989899, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI17975518, Length=198, Percent_Identity=39.8989898989899, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24581278, Length=213, Percent_Identity=34.2723004694836, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17738015, Length=148, Percent_Identity=37.8378378378378, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17157991, Length=155, Percent_Identity=36.7741935483871, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24641739, Length=155, Percent_Identity=36.7741935483871, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24656348, Length=153, Percent_Identity=35.2941176470588, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17864676, Length=153, Percent_Identity=35.2941176470588, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=34.9315068493151, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH1_SULTO (Q974S8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376470.1
- ProteinModelPortal:   Q974S8
- SMR:   Q974S8
- GeneID:   1458529
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0584
- NMPDR:   fig|273063.1.peg.638
- HOGENOM:   HBG493509
- OMA:   DSIYSHI
- ProtClustDB:   PRK13190
- BioCyc:   STOK273063:ST0584-MONOMER
- BRENDA:   1.11.1.15
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 24558; Mature: 24558

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 46-46

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLYSKFPDVQVLTTKGPIDFYKDIFGKGKWLFLFAHPADFTPVCTTEFVAFSQKYEEF
CCCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
KKLGVELVGLSVDSIYSHIQWLMDIEQRYGVKVPFPVIADPDKKLARMLDALDEASGQTI
HHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCEE
RIVVLASPDGIIRFVAQYPMEFGRNIDELLRITKAAIVNYKAKVVLPANWQPGQDVIVPP
EEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEECC
PAIFDEAEMRIKLPNAKAWYLLFKKYEELPPDQKV
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVKLYSKFPDVQVLTTKGPIDFYKDIFGKGKWLFLFAHPADFTPVCTTEFVAFSQKYEEF
CCCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
KKLGVELVGLSVDSIYSHIQWLMDIEQRYGVKVPFPVIADPDKKLARMLDALDEASGQTI
HHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCEE
RIVVLASPDGIIRFVAQYPMEFGRNIDELLRITKAAIVNYKAKVVLPANWQPGQDVIVPP
EEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEECC
PAIFDEAEMRIKLPNAKAWYLLFKKYEELPPDQKV
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479