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The map label for this gene is trxB [H]

Identifier: 15920765

GI number: 15920765

Start: 539430

End: 540404

Strand: Direct

Name: trxB [H]

Synonym: ST0546

Alternate gene names: 15920765

Gene position: 539430-540404 (Clockwise)

Preceding gene: 15920762

Following gene: 15920766

Centisome position: 20.02

GC content: 35.18

Gene sequence:

>975_bases
ATGATGAGTCTTTTACCTAGAGCATTTGATGTAAGACCAGGAGAAAAGTTTGATGTGGTTATAATTGGTATGGGTCCTGC
AGCGTATAGTGCAGCCCTATATAGTGCAAGGTTTATGCTAAAGACTCTAATGATAGGTGAGACACCTGGAGGACAATTAA
CAGAAGCTGGAGAGGTTGATGATTATTTAGGTTTAATTGGAATTCAAGCTGCTGATATGATAAAATTATTCAATAAACAC
ATAGAAAAATATAACGTCCCTGCAATTATGGATACAGTAGAATACTTTAGAAAAGAAAATAATGAATTTATCGTTAAAAC
TAAAAGAAGAGGAGAGTTCAAAGCTGATGCAATAATAGTTGCGGTAGGCGTAAAGAGAAGAAAATTAAATGTGCCAGGAG
AAGCTGAATTTACTGGTAAAGGTGTTTCTTATTGTTCAGTTTGTGATGCTCCGCTATTCAAGAACAGACCAGTTGTTGTT
GTTGGAGGAGGAGATTCTGCATTAGAAGGAGCTGAGATTCTTTCTCGTTATGCAACTAAAGTATATCTTGTACATAGAAG
AGATGAATTTAAAGCACAACCAATTTATGTAGAGAGCGTAAAGCAAAAACCAAATGTTGAGTTTATCTTAAATTCAGTAG
TTAAAGAAATTAAAGGTGACAAAATAGTTAGAAAGGTTATTGTTCAAAATCTAAAGACTAATGAAATTAGAGAACTCGAT
GTTAATGGAGTGTTTGTTGAAATTGGTTTCGATCCGCCAACAGATTTTGCGAGGCAAAATGGCCTAGAAGTAGATTCACA
TGGGTATATTAAGGTAGATGAATGGATGAGAACTAATATAGAAGGTGTATATGCTGCTGGTGATTGTACTGGGATGTGGT
TAGGTTTTAGGCAAATTATAACTTCAGCTGCACAAGGTGCGGTAGCCGCACATAGTGCTTTTAATTATTTAACAGAGAAA
AAGAGGAAAAAGTAA

Upstream 100 bases:

>100_bases
TTCCGGTTACTAGTAACACTTTCACATACTATCTTTCTTAATTTAGGATTAAAAATACCGTTATTAGAAACTCTTTTATT
TACTTTAACACATAATATTA

Downstream 100 bases:

>100_bases
TGCGAGAGGTTTTAGTAAAGATTACAAAGGAAATAATTTCTTTCCTATATGAAGAAAAAGATAAACAAGGTATTGATAAA
ATCATAGGAAAACATGGAAA

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MMSLLPRAFDVRPGEKFDVVIIGMGPAAYSAALYSARFMLKTLMIGETPGGQLTEAGEVDDYLGLIGIQAADMIKLFNKH
IEKYNVPAIMDTVEYFRKENNEFIVKTKRRGEFKADAIIVAVGVKRRKLNVPGEAEFTGKGVSYCSVCDAPLFKNRPVVV
VGGGDSALEGAEILSRYATKVYLVHRRDEFKAQPIYVESVKQKPNVEFILNSVVKEIKGDKIVRKVIVQNLKTNEIRELD
VNGVFVEIGFDPPTDFARQNGLEVDSHGYIKVDEWMRTNIEGVYAAGDCTGMWLGFRQIITSAAQGAVAAHSAFNYLTEK
KRKK

Sequences:

>Translated_324_residues
MMSLLPRAFDVRPGEKFDVVIIGMGPAAYSAALYSARFMLKTLMIGETPGGQLTEAGEVDDYLGLIGIQAADMIKLFNKH
IEKYNVPAIMDTVEYFRKENNEFIVKTKRRGEFKADAIIVAVGVKRRKLNVPGEAEFTGKGVSYCSVCDAPLFKNRPVVV
VGGGDSALEGAEILSRYATKVYLVHRRDEFKAQPIYVESVKQKPNVEFILNSVVKEIKGDKIVRKVIVQNLKTNEIRELD
VNGVFVEIGFDPPTDFARQNGLEVDSHGYIKVDEWMRTNIEGVYAAGDCTGMWLGFRQIITSAAQGAVAAHSAFNYLTEK
KRKK
>Mature_324_residues
MMSLLPRAFDVRPGEKFDVVIIGMGPAAYSAALYSARFMLKTLMIGETPGGQLTEAGEVDDYLGLIGIQAADMIKLFNKH
IEKYNVPAIMDTVEYFRKENNEFIVKTKRRGEFKADAIIVAVGVKRRKLNVPGEAEFTGKGVSYCSVCDAPLFKNRPVVV
VGGGDSALEGAEILSRYATKVYLVHRRDEFKAQPIYVESVKQKPNVEFILNSVVKEIKGDKIVRKVIVQNLKTNEIRELD
VNGVFVEIGFDPPTDFARQNGLEVDSHGYIKVDEWMRTNIEGVYAAGDCTGMWLGFRQIITSAAQGAVAAHSAFNYLTEK
KRKK

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=175, Percent_Identity=33.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI65787454, Length=175, Percent_Identity=33.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21389617, Length=175, Percent_Identity=33.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787114, Length=314, Percent_Identity=37.8980891719745, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI87081763, Length=315, Percent_Identity=34.9206349206349, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17559934, Length=224, Percent_Identity=29.9107142857143, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321898, Length=317, Percent_Identity=35.3312302839117, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320560, Length=314, Percent_Identity=35.3503184713376, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 36041; Mature: 36041

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSLLPRAFDVRPGEKFDVVIIGMGPAAYSAALYSARFMLKTLMIGETPGGQLTEAGEVD
CCCCCCCHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
DYLGLIGIQAADMIKLFNKHIEKYNVPAIMDTVEYFRKENNEFIVKTKRRGEFKADAIIV
HHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
AVGVKRRKLNVPGEAEFTGKGVSYCSVCDAPLFKNRPVVVVGGGDSALEGAEILSRYATK
EECCEEEEECCCCCCCCCCCCCCEEHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHE
VYLVHRRDEFKAQPIYVESVKQKPNVEFILNSVVKEIKGDKIVRKVIVQNLKTNEIRELD
EEEEEECCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEE
VNGVFVEIGFDPPTDFARQNGLEVDSHGYIKVDEWMRTNIEGVYAAGDCTGMWLGFRQII
CCEEEEEECCCCCHHHHHHCCCEECCCCCEEEHHHHHCCCCEEEECCCCHHHHHHHHHHH
TSAAQGAVAAHSAFNYLTEKKRKK
HHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMSLLPRAFDVRPGEKFDVVIIGMGPAAYSAALYSARFMLKTLMIGETPGGQLTEAGEVD
CCCCCCCHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
DYLGLIGIQAADMIKLFNKHIEKYNVPAIMDTVEYFRKENNEFIVKTKRRGEFKADAIIV
HHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
AVGVKRRKLNVPGEAEFTGKGVSYCSVCDAPLFKNRPVVVVGGGDSALEGAEILSRYATK
EECCEEEEECCCCCCCCCCCCCCEEHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHE
VYLVHRRDEFKAQPIYVESVKQKPNVEFILNSVVKEIKGDKIVRKVIVQNLKTNEIRELD
EEEEEECCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEE
VNGVFVEIGFDPPTDFARQNGLEVDSHGYIKVDEWMRTNIEGVYAAGDCTGMWLGFRQII
CCEEEEEECCCCCHHHHHHCCCEECCCCCEEEHHHHHCCCCEEEECCCCHHHHHHHHHHH
TSAAQGAVAAHSAFNYLTEKKRKK
HHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]