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The map label for this gene is adhP [C]

Identifier: 15920695

GI number: 15920695

Start: 480166

End: 481170

Strand: Direct

Name: adhP [C]

Synonym: ST0480

Alternate gene names: 15920695

Gene position: 480166-481170 (Clockwise)

Preceding gene: 15920688

Following gene: 15920696

Centisome position: 17.82

GC content: 36.72

Gene sequence:

>1005_bases
ATGAAAGCAATTGTAGTTCCAGGACCTAAGCAAGGGTATAAACTTGAAGAGGTACCTGATCCTAAGCCGGGAAAAGATGA
AGTAATAATTAGGGTAGATAGAGCTGCTCTTTGTTATAGAGATTTGCTTCAACTACAAGGATATTATCCAAGAATGAAAT
ACCCAGTTATACTAGGGCATGAAGTTGTAGGAACCATAGAAGAAGTCGGAGAAAATATAAAGGGATTTGAAGTAGGTGAT
AAAGTAATTTCTTTATTATATGCACCAGATGGTACATGCGAATATTGCCAAATAGGTGAGGAAGCATATTGTCATCATAG
GTTAGGCTACTCAGAAGAGCTAGACGGATTTTTTGCAGAGAAAGCTAAAATTAAAGTAACTAGCTTAGTAAAGGTTCCAA
AAGGTACCCCAGATGAGGGAGCAGTACTTGTACCTTGTGTAACCGGAATGATATATAGAGGTATTAGAAGGGCTGGTGGT
ATACGTAAAGGGGAGCTAGTGTTAGTTACTGGTGCCAGTGGTGGAGTAGGAATACATGCAATTCAAGTTGCTAAGGCCTT
AGGTGCTAAAGTTATAGGGGTAACAACATCAGAAGAAAAAGCAAAGATAATTAAGCAGTATGCGGATTATGTCATCGTTG
GTACAAAGTTTTCTGAAGAAGCAAAGAAGATAGGTGATGTTACTTTAGTTATTGATACTGTGGGTACTCCTACTTTCGAT
GAAAGCTTAAAGTCATTGTGGATGGGCGGAAGGATTGTTCAAATAGGGAATGTCGACCCTTCTCAAATCTATAATTTAAG
ATTGGGCTACATAATATTAAAAGATTTAAAGATAGTTGGTCATGCCTCAGCTACCAAAAAAGATGCTGAAGATACACTAA
AATTAACACAAGAGGGAAAAATTAAACCAGTTATTGCAGGAACAGTCAGTCTTGAAAATATTGATGAAGGTTATAAAATG
ATAAAGGATAAGAATAAAGTAGGCAAAGTCTTAGTAAAACCATAA

Upstream 100 bases:

>100_bases
TTTTATTCGTGGAGGATTTTTTAAATACATAATTATAAAATCGAGCGTAAGGTAATAAGCTAATAAAAAATTTATACTAT
TTAAACAGTATAAGCAATAA

Downstream 100 bases:

>100_bases
AATTTTAACTGAATATGATACTACTGTGAAGTTAAAATTTTCCTCTATTGAAATAAAAAGTGATCTACTTCCTCATAGTG
AGAATGATACAAACCAATAT

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKAIVVPGPKQGYKLEEVPDPKPGKDEVIIRVDRAALCYRDLLQLQGYYPRMKYPVILGHEVVGTIEEVGENIKGFEVGD
KVISLLYAPDGTCEYCQIGEEAYCHHRLGYSEELDGFFAEKAKIKVTSLVKVPKGTPDEGAVLVPCVTGMIYRGIRRAGG
IRKGELVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAKIIKQYADYVIVGTKFSEEAKKIGDVTLVIDTVGTPTFD
ESLKSLWMGGRIVQIGNVDPSQIYNLRLGYIILKDLKIVGHASATKKDAEDTLKLTQEGKIKPVIAGTVSLENIDEGYKM
IKDKNKVGKVLVKP

Sequences:

>Translated_334_residues
MKAIVVPGPKQGYKLEEVPDPKPGKDEVIIRVDRAALCYRDLLQLQGYYPRMKYPVILGHEVVGTIEEVGENIKGFEVGD
KVISLLYAPDGTCEYCQIGEEAYCHHRLGYSEELDGFFAEKAKIKVTSLVKVPKGTPDEGAVLVPCVTGMIYRGIRRAGG
IRKGELVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAKIIKQYADYVIVGTKFSEEAKKIGDVTLVIDTVGTPTFD
ESLKSLWMGGRIVQIGNVDPSQIYNLRLGYIILKDLKIVGHASATKKDAEDTLKLTQEGKIKPVIAGTVSLENIDEGYKM
IKDKNKVGKVLVKP
>Mature_334_residues
MKAIVVPGPKQGYKLEEVPDPKPGKDEVIIRVDRAALCYRDLLQLQGYYPRMKYPVILGHEVVGTIEEVGENIKGFEVGD
KVISLLYAPDGTCEYCQIGEEAYCHHRLGYSEELDGFFAEKAKIKVTSLVKVPKGTPDEGAVLVPCVTGMIYRGIRRAGG
IRKGELVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAKIIKQYADYVIVGTKFSEEAKKIGDVTLVIDTVGTPTFD
ESLKSLWMGGRIVQIGNVDPSQIYNLRLGYIILKDLKIVGHASATKKDAEDTLKLTQEGKIKPVIAGTVSLENIDEGYKM
IKDKNKVGKVLVKP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI194239674, Length=331, Percent_Identity=27.190332326284, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI13236495, Length=331, Percent_Identity=27.190332326284, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI156627571, Length=346, Percent_Identity=30.0578034682081, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI22538446, Length=348, Percent_Identity=22.9885057471264, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI22538444, Length=348, Percent_Identity=22.9885057471264, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501939, Length=222, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI156523966, Length=222, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI71743840, Length=225, Percent_Identity=27.1111111111111, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI262073058, Length=225, Percent_Identity=27.1111111111111, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=25.1336898395722, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI34577061, Length=226, Percent_Identity=28.3185840707965, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4501929, Length=226, Percent_Identity=29.2035398230088, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI194239676, Length=325, Percent_Identity=25.8461538461538, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71565154, Length=233, Percent_Identity=27.0386266094421, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI47519420, Length=349, Percent_Identity=24.6418338108883, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI28557745, Length=275, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081918, Length=290, Percent_Identity=27.9310344827586, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790045, Length=347, Percent_Identity=25.3602305475504, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=28.8184438040346, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=24.8538011695906, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788407, Length=330, Percent_Identity=25.1515151515152, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786825, Length=397, Percent_Identity=24.4332493702771, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=313, Percent_Identity=26.517571884984, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790485, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082125, Length=360, Percent_Identity=26.3888888888889, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=339, Percent_Identity=24.188790560472, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=23.936170212766, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788073, Length=269, Percent_Identity=26.3940520446097, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082401, Length=336, Percent_Identity=21.7261904761905, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=321, Percent_Identity=27.7258566978193, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=23.9393939393939, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=327, Percent_Identity=25.3822629969419, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=221, Percent_Identity=28.9592760180996, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=233, Percent_Identity=29.1845493562232, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=262, Percent_Identity=27.0992366412214, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=235, Percent_Identity=29.3617021276596, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=229, Percent_Identity=27.9475982532751, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=333, Percent_Identity=28.5285285285285, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=28.4023668639053, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=344, Percent_Identity=26.7441860465116, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=28.1437125748503, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319520, Length=339, Percent_Identity=28.3185840707965, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=239, Percent_Identity=27.6150627615063, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=285, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=285, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=304, Percent_Identity=26.9736842105263, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=367, Percent_Identity=25.3405994550409, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=299, Percent_Identity=25.752508361204, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737895, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581345, Length=234, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737897, Length=188, Percent_Identity=30.3191489361702, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI221330659, Length=224, Percent_Identity=27.2321428571429, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920632, Length=226, Percent_Identity=26.5486725663717, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137530, Length=191, Percent_Identity=29.3193717277487, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACAR_SULTO (Q975C8)

Other databases:

- EMBL:   BA000023
- EMBL:   FJ445417
- RefSeq:   NP_376364.1
- HSSP:   Q59096
- ProteinModelPortal:   Q975C8
- SMR:   Q975C8
- GeneID:   1458422
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0480
- NMPDR:   fig|273063.1.peg.532
- HOGENOM:   HBG753318
- OMA:   VQIGNVD
- ProtClustDB:   PRK13771
- BioCyc:   MetaCyc:MONOMER-13730
- BioCyc:   STOK273063:ST0480-MONOMER
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.3.1.84

Molecular weight: Translated: 36301; Mature: 36301

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00059 ADH_ZINC; PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVVPGPKQGYKLEEVPDPKPGKDEVIIRVDRAALCYRDLLQLQGYYPRMKYPVILGH
CCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTIEEVGENIKGFEVGDKVISLLYAPDGTCEYCQIGEEAYCHHRLGYSEELDGFFAE
HHHHHHHHHCCCCCCEEHHHHHEEEEECCCCCCHHHHCCCHHHHHHHCCCCHHHCCHHHH
KAKIKVTSLVKVPKGTPDEGAVLVPCVTGMIYRGIRRAGGIRKGELVLVTGASGGVGIHA
CCEEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
IQVAKALGAKVIGVTTSEEKAKIIKQYADYVIVGTKFSEEAKKIGDVTLVIDTVGTPTFD
HHHHHHHCCEEEEEECCHHHHHHHHHHCCEEEEECCCHHHHHHHCCEEEEEECCCCCCHH
ESLKSLWMGGRIVQIGNVDPSQIYNLRLGYIILKDLKIVGHASATKKDAEDTLKLTQEGK
HHHHHHHCCCEEEEECCCCHHHHEEEEEEEEEEEEHHEEECCCCCCCCHHHHHHHCCCCC
IKPVIAGTVSLENIDEGYKMIKDKNKVGKVLVKP
EEEEEEEEEEHHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MKAIVVPGPKQGYKLEEVPDPKPGKDEVIIRVDRAALCYRDLLQLQGYYPRMKYPVILGH
CCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTIEEVGENIKGFEVGDKVISLLYAPDGTCEYCQIGEEAYCHHRLGYSEELDGFFAE
HHHHHHHHHCCCCCCEEHHHHHEEEEECCCCCCHHHHCCCHHHHHHHCCCCHHHCCHHHH
KAKIKVTSLVKVPKGTPDEGAVLVPCVTGMIYRGIRRAGGIRKGELVLVTGASGGVGIHA
CCEEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
IQVAKALGAKVIGVTTSEEKAKIIKQYADYVIVGTKFSEEAKKIGDVTLVIDTVGTPTFD
HHHHHHHCCEEEEEECCHHHHHHHHHHCCEEEEECCCHHHHHHHCCEEEEEECCCCCCHH
ESLKSLWMGGRIVQIGNVDPSQIYNLRLGYIILKDLKIVGHASATKKDAEDTLKLTQEGK
HHHHHHHCCCEEEEECCCCHHHHEEEEEEEEEEEEHHEEECCCCCCCCHHHHHHHCCCCC
IKPVIAGTVSLENIDEGYKMIKDKNKVGKVLVKP
EEEEEEEEEEHHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479