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The map label for this gene is glyS [H]

Identifier: 15920555

GI number: 15920555

Start: 374054

End: 375769

Strand: Direct

Name: glyS [H]

Synonym: ST0353

Alternate gene names: 15920555

Gene position: 374054-375769 (Clockwise)

Preceding gene: 161751101

Following gene: 15920556

Centisome position: 13.88

GC content: 31.47

Gene sequence:

>1716_bases
ATGAGTGAGAAGTTAATTGAATTGGCGAAAAGAAGAGGAATATTTTGGCCTTCATATGAAATTTATGGCGGTGTTGCAGG
ACTTTATGATATTGGTCCTATTGGAGTTAGAATAAAAAATAAAATTATTGAGCTATGGAGAAGATATTTTATCTATGATA
ATTCTGAGTTTGTAGTAGAAATTGAAACACCAATGATAACGCCTTATAAAGTATTAGAAGCTAGTGGTCATGTGGAAAAC
TTTACAGATCCAATTGTCGAATGTACAAAATGTCATAAAATTTATAGAGCAGACCATCTTATTGAAGAATTGGCTAAAAT
AAATGTTGAGGGTCTTTCGCCATCAGAATTAGATAGAATAATTAGAGAAAAAGGGCTAAAATGCCCTGCTTGTGGTGGTG
AATTGGGTGAGGTAAGACTATTTAATTTACTTTTTACTACAAATATCGGTCCATATACTGGTAATCAAGGATTTTTAAGA
CCAGAAACAGCACAAGGAATGTTTACCTCATTTAAGAGAGTTTTTGAGGCATTTAGACAAAAATTACCTTTAGGCATTGC
ACAAGTAGGTAGGGTCGCTAGGAATGAAATTTCTCCTAGGCAAGGTCTAATAAGAATGAGAGAATTTACCATAATGGAAG
TAGAATTTTTCTTTGACCCAGAAAGTAATGTAAATCCACCTCTTGAAAAATTCGGCAATATGAAGCTTAATATCTTAAGG
GGAGAGGACAAACTTAAGAATGAAAAACCGAAAGAATATAGTATTGAAGAACTTCTAAAGGAAAAGATAGTGTTGAATCC
TTGGATGTTATATTGGATGGCTACTGCTGCTAAATTTGTCACCGCATTAGGTATGAAATCATATTATTTTGAAGAAAAAT
TACCTCATGAAAGAGCGCACTATTCTAAGCAAACTTTTGATCAAATTGTTGTTATAGGAGACGAAAAAGTTGAAATCTCT
GGGCATGCATATAGAACTGATTACGATTTAAGTAGACATATGAAGTATAGTGGACAAGATATGACTGTTTTTAAAAAATA
TGATAAGCCGAAAACTATAAAGAGAAAGATAGTTGTAATTAATAAAGATTCTCTAAATAAGGAAGATAAAGAATTTGTGA
AGAATTTTATGAGTTTTATATCTTCTAAAAAACCAGAAGAAATAGAGGAATTTATTAATGCAAATGAGAAAGTAAATGGT
AAAAACATATCTAATTATGTAAAAATATTAGAGAAGGAAGAGAAAGTTAACGGTGAAAAAATCATACCTCATGTAGTTGA
GCCCTCTTTTGGTGTTGAGAGATGTTTATATCTAACTCTATTAAATGCTTATAAGGAGAAAGAAGGAAGGATAGTGTTAT
CATTACCTAAATATTTAGCTCCTTATGATGTTGCTGTATTTCCACTTTTAGAAAAGGAGGAGCTTATTAACAAGGCTAAA
GAAGTATATAATCTCGTCAGAGAAAGATTTGATACAATTTTTGATGATTCTGGTAGTATAGGGAAAAGATATGCTAGAGC
TGATGAAATTGGTGTTCCTTATTCTATAACGATTGATCCACAGACTTTAGTTGATAATTCTGTAACTATTAGGGACAGAG
ATACTTGGCAGCAAATAAGAGTTAATATTAACGATATTGTCTCGGTATTAGAAAGGTTGTTTAAGGGTGAAGAGTTTAAT
AAGGTAGGTAAAGTAATTAATAATGAAAATGAGTAA

Upstream 100 bases:

>100_bases
TTAAATCCGGCAAATAATCTACTATTTTCATTTAAGTATAGTAACCTGCTATCTGACATGAGAGTAGAAATTTTTAATCT
TGTTTATATGCTTATCTCGT

Downstream 100 bases:

>100_bases
GGATGAAAAAGAAGAGGAAAAGAAGGTTGATGTAAAATCTTTAGTAAATATTATACCTCCTGCATCTTCTTTAAAGAAGA
GTAAAGCTCCGCCTAAAGAA

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MSEKLIELAKRRGIFWPSYEIYGGVAGLYDIGPIGVRIKNKIIELWRRYFIYDNSEFVVEIETPMITPYKVLEASGHVEN
FTDPIVECTKCHKIYRADHLIEELAKINVEGLSPSELDRIIREKGLKCPACGGELGEVRLFNLLFTTNIGPYTGNQGFLR
PETAQGMFTSFKRVFEAFRQKLPLGIAQVGRVARNEISPRQGLIRMREFTIMEVEFFFDPESNVNPPLEKFGNMKLNILR
GEDKLKNEKPKEYSIEELLKEKIVLNPWMLYWMATAAKFVTALGMKSYYFEEKLPHERAHYSKQTFDQIVVIGDEKVEIS
GHAYRTDYDLSRHMKYSGQDMTVFKKYDKPKTIKRKIVVINKDSLNKEDKEFVKNFMSFISSKKPEEIEEFINANEKVNG
KNISNYVKILEKEEKVNGEKIIPHVVEPSFGVERCLYLTLLNAYKEKEGRIVLSLPKYLAPYDVAVFPLLEKEELINKAK
EVYNLVRERFDTIFDDSGSIGKRYARADEIGVPYSITIDPQTLVDNSVTIRDRDTWQQIRVNINDIVSVLERLFKGEEFN
KVGKVINNENE

Sequences:

>Translated_571_residues
MSEKLIELAKRRGIFWPSYEIYGGVAGLYDIGPIGVRIKNKIIELWRRYFIYDNSEFVVEIETPMITPYKVLEASGHVEN
FTDPIVECTKCHKIYRADHLIEELAKINVEGLSPSELDRIIREKGLKCPACGGELGEVRLFNLLFTTNIGPYTGNQGFLR
PETAQGMFTSFKRVFEAFRQKLPLGIAQVGRVARNEISPRQGLIRMREFTIMEVEFFFDPESNVNPPLEKFGNMKLNILR
GEDKLKNEKPKEYSIEELLKEKIVLNPWMLYWMATAAKFVTALGMKSYYFEEKLPHERAHYSKQTFDQIVVIGDEKVEIS
GHAYRTDYDLSRHMKYSGQDMTVFKKYDKPKTIKRKIVVINKDSLNKEDKEFVKNFMSFISSKKPEEIEEFINANEKVNG
KNISNYVKILEKEEKVNGEKIIPHVVEPSFGVERCLYLTLLNAYKEKEGRIVLSLPKYLAPYDVAVFPLLEKEELINKAK
EVYNLVRERFDTIFDDSGSIGKRYARADEIGVPYSITIDPQTLVDNSVTIRDRDTWQQIRVNINDIVSVLERLFKGEEFN
KVGKVINNENE
>Mature_570_residues
SEKLIELAKRRGIFWPSYEIYGGVAGLYDIGPIGVRIKNKIIELWRRYFIYDNSEFVVEIETPMITPYKVLEASGHVENF
TDPIVECTKCHKIYRADHLIEELAKINVEGLSPSELDRIIREKGLKCPACGGELGEVRLFNLLFTTNIGPYTGNQGFLRP
ETAQGMFTSFKRVFEAFRQKLPLGIAQVGRVARNEISPRQGLIRMREFTIMEVEFFFDPESNVNPPLEKFGNMKLNILRG
EDKLKNEKPKEYSIEELLKEKIVLNPWMLYWMATAAKFVTALGMKSYYFEEKLPHERAHYSKQTFDQIVVIGDEKVEISG
HAYRTDYDLSRHMKYSGQDMTVFKKYDKPKTIKRKIVVINKDSLNKEDKEFVKNFMSFISSKKPEEIEEFINANEKVNGK
NISNYVKILEKEEKVNGEKIIPHVVEPSFGVERCLYLTLLNAYKEKEGRIVLSLPKYLAPYDVAVFPLLEKEELINKAKE
VYNLVRERFDTIFDDSGSIGKRYARADEIGVPYSITIDPQTLVDNSVTIRDRDTWQQIRVNINDIVSVLERLFKGEEFNK
VGKVINNENE

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=592, Percent_Identity=32.6013513513513, Blast_Score=319, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17554996, Length=600, Percent_Identity=34.3333333333333, Blast_Score=335, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI32564541, Length=600, Percent_Identity=34.3333333333333, Blast_Score=335, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6325338, Length=591, Percent_Identity=33.6717428087986, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6319597, Length=621, Percent_Identity=30.5958132045089, Blast_Score=294, Evalue=3e-80,
Organism=Drosophila melanogaster, GI21357965, Length=579, Percent_Identity=36.2694300518135, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24664462, Length=579, Percent_Identity=36.2694300518135, Blast_Score=349, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022960
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 66197; Mature: 66066

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKLIELAKRRGIFWPSYEIYGGVAGLYDIGPIGVRIKNKIIELWRRYFIYDNSEFVVE
CCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCEEEEE
IETPMITPYKVLEASGHVENFTDPIVECTKCHKIYRADHLIEELAKINVEGLSPSELDRI
ECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IREKGLKCPACGGELGEVRLFNLLFTTNIGPYTGNQGFLRPETAQGMFTSFKRVFEAFRQ
HHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KLPLGIAQVGRVARNEISPRQGLIRMREFTIMEVEFFFDPESNVNPPLEKFGNMKLNILR
HCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEEEEEEEECCCCCCCCCHHHHCCCEEEEEE
GEDKLKNEKPKEYSIEELLKEKIVLNPWMLYWMATAAKFVTALGMKSYYFEEKLPHERAH
CCHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YSKQTFDQIVVIGDEKVEISGHAYRTDYDLSRHMKYSGQDMTVFKKYDKPKTIKRKIVVI
HHHHCCCEEEEECCCEEEECCCEEECCCCHHHHHCCCCCCEEEEECCCCCCCEEEEEEEE
NKDSLNKEDKEFVKNFMSFISSKKPEEIEEFINANEKVNGKNISNYVKILEKEEKVNGEK
ECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
IIPHVVEPSFGVERCLYLTLLNAYKEKEGRIVLSLPKYLAPYDVAVFPLLEKEELINKAK
CCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHCCCCCEEEECCCCHHHHHHHHH
EVYNLVRERFDTIFDDSGSIGKRYARADEIGVPYSITIDPQTLVDNSVTIRDRDTWQQIR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECHHHHCCCCEEEECCCCHHHHH
VNINDIVSVLERLFKGEEFNKVGKVINNENE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEKLIELAKRRGIFWPSYEIYGGVAGLYDIGPIGVRIKNKIIELWRRYFIYDNSEFVVE
CHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCEEEEE
IETPMITPYKVLEASGHVENFTDPIVECTKCHKIYRADHLIEELAKINVEGLSPSELDRI
ECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IREKGLKCPACGGELGEVRLFNLLFTTNIGPYTGNQGFLRPETAQGMFTSFKRVFEAFRQ
HHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KLPLGIAQVGRVARNEISPRQGLIRMREFTIMEVEFFFDPESNVNPPLEKFGNMKLNILR
HCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEEEEEEEECCCCCCCCCHHHHCCCEEEEEE
GEDKLKNEKPKEYSIEELLKEKIVLNPWMLYWMATAAKFVTALGMKSYYFEEKLPHERAH
CCHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YSKQTFDQIVVIGDEKVEISGHAYRTDYDLSRHMKYSGQDMTVFKKYDKPKTIKRKIVVI
HHHHCCCEEEEECCCEEEECCCEEECCCCHHHHHCCCCCCEEEEECCCCCCCEEEEEEEE
NKDSLNKEDKEFVKNFMSFISSKKPEEIEEFINANEKVNGKNISNYVKILEKEEKVNGEK
ECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
IIPHVVEPSFGVERCLYLTLLNAYKEKEGRIVLSLPKYLAPYDVAVFPLLEKEELINKAK
CCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHCCCCCEEEECCCCHHHHHHHHH
EVYNLVRERFDTIFDDSGSIGKRYARADEIGVPYSITIDPQTLVDNSVTIRDRDTWQQIR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECHHHHCCCCEEEECCCCHHHHH
VNINDIVSVLERLFKGEEFNKVGKVINNENE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]