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The map label for this gene is ahcY

Identifier: 15920541

GI number: 15920541

Start: 359720

End: 360967

Strand: Direct

Name: ahcY

Synonym: ST0342

Alternate gene names: 15920541

Gene position: 359720-360967 (Clockwise)

Preceding gene: 15920540

Following gene: 15920542

Centisome position: 13.35

GC content: 34.46

Gene sequence:

>1248_bases
ATGGACTATAAGGTTAAAGATCTTAGTTTAGCTGAACAAGGTAAAAAACAAATAGAATGGGCAGAAATACACATGCCAGC
ATTAATGGAGATAAGAAAGCAATTTGAGAAAGAAAAACCTCTTCAAGGATTAAGGATTAGTGCTGTCCTTCACGTAACTA
AGGAAACTGCTGTATTAGTTAAGACTCTAAAAATAGGAGGAGCTACAGTTGCATTAGCTGGTAGTAATCCGTTATCTACT
CAAGATGACGTTGCTGCTGCACTAGTTGAGGAGGGAATTCGTGTATTTGCATGGAGAGGTGAAACTGAAAAAGATTATTA
TGATAATATTAAAGAAATTCTAAAATATGAACCTCAAATAATAATGGATGATGGAGGAGATCTTCATGCTTATGTCCACG
AAAATATGCCACAGTTAAAACTATTTGGGGGTACAGAAGAAACAACAACAGGAGTAATAAGACTAAAGGCCATGGAAGAA
CAAGGAGTCCTAAGATATCCAGTAATCGCTGTAAATAATGCTTTTACAAAATACTTATTTGATAATAGAATAGGTACTGG
ACAGAGTACAATAGATGGAATACTTAGAGCAACAAATATACTAATTGCTGGTAAAGTAGCTGTAGTAGCTGGATACGGAT
GGGTAGGAAGAGGGATAGCTCAAAGGCTTAGAGGTATGGGTGCTAGGGTTATAGTGGTCGAAGTATCTCCTTTAAGAGCA
TTAGAGGCAGTTATGGATGGTTTTGATGTAATGCCAATGAGTAAAGCTGCAGAATTAGGGGAGATTTTTATCACTGCTAC
CGGTAATATAAACGTAATAAGAAAAGAACATATTCTAAAAATGAAAGATGGTGCAATTTTAGCAAACTCTGGGCATTTTA
ATGTAGAGATAGACGTAAAAGGATTAAAAGAAATGGCAAAATCATCAAGATTGATAAGACCAAACTTGGAAGAATATGAA
TTACCTAATGGAAAAAGAATTTATTTATTAGCTGAAGGTAGATTAGTTAATTTAGCTGCAGCCGAGGGACATCCTAGTGA
GGTTATGGATTTAAGCTTTTCAAATCAAGCTTTATCGGTAAAGTATATTTATGAAAATAGAGGAAAGTTAGAGAATAAAG
TATATAATGTTCCACAAGAGATAGATGAAACGGTTGCTAAATTAAAATTAAATGGAATGGGAATAGAAATAGAGCCAATG
ACACAAGAACAAATAGAATACATGAAACAATGGAGATATGGTACTTGA

Upstream 100 bases:

>100_bases
CGATCATAGTTGGTGCGATAACGGCACTTACATCAGTAAGAGTTGCTAGGGCAATAGGAGCATAAGTTAAACTTTTTTTA
TTATTTTCTTTTTACACCCT

Downstream 100 bases:

>100_bases
CCTTTTTTACTTAGCGTAACTCTTTTAAATCATTTTAGCATATTTGTTTATTGGGCCCGTAGCTTAGCCCGGTAGAGCGC
CCGGCTCATAAAGATCCTTC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDYKVKDLSLAEQGKKQIEWAEIHMPALMEIRKQFEKEKPLQGLRISAVLHVTKETAVLVKTLKIGGATVALAGSNPLST
QDDVAAALVEEGIRVFAWRGETEKDYYDNIKEILKYEPQIIMDDGGDLHAYVHENMPQLKLFGGTEETTTGVIRLKAMEE
QGVLRYPVIAVNNAFTKYLFDNRIGTGQSTIDGILRATNILIAGKVAVVAGYGWVGRGIAQRLRGMGARVIVVEVSPLRA
LEAVMDGFDVMPMSKAAELGEIFITATGNINVIRKEHILKMKDGAILANSGHFNVEIDVKGLKEMAKSSRLIRPNLEEYE
LPNGKRIYLLAEGRLVNLAAAEGHPSEVMDLSFSNQALSVKYIYENRGKLENKVYNVPQEIDETVAKLKLNGMGIEIEPM
TQEQIEYMKQWRYGT

Sequences:

>Translated_415_residues
MDYKVKDLSLAEQGKKQIEWAEIHMPALMEIRKQFEKEKPLQGLRISAVLHVTKETAVLVKTLKIGGATVALAGSNPLST
QDDVAAALVEEGIRVFAWRGETEKDYYDNIKEILKYEPQIIMDDGGDLHAYVHENMPQLKLFGGTEETTTGVIRLKAMEE
QGVLRYPVIAVNNAFTKYLFDNRIGTGQSTIDGILRATNILIAGKVAVVAGYGWVGRGIAQRLRGMGARVIVVEVSPLRA
LEAVMDGFDVMPMSKAAELGEIFITATGNINVIRKEHILKMKDGAILANSGHFNVEIDVKGLKEMAKSSRLIRPNLEEYE
LPNGKRIYLLAEGRLVNLAAAEGHPSEVMDLSFSNQALSVKYIYENRGKLENKVYNVPQEIDETVAKLKLNGMGIEIEPM
TQEQIEYMKQWRYGT
>Mature_415_residues
MDYKVKDLSLAEQGKKQIEWAEIHMPALMEIRKQFEKEKPLQGLRISAVLHVTKETAVLVKTLKIGGATVALAGSNPLST
QDDVAAALVEEGIRVFAWRGETEKDYYDNIKEILKYEPQIIMDDGGDLHAYVHENMPQLKLFGGTEETTTGVIRLKAMEE
QGVLRYPVIAVNNAFTKYLFDNRIGTGQSTIDGILRATNILIAGKVAVVAGYGWVGRGIAQRLRGMGARVIVVEVSPLRA
LEAVMDGFDVMPMSKAAELGEIFITATGNINVIRKEHILKMKDGAILANSGHFNVEIDVKGLKEMAKSSRLIRPNLEEYE
LPNGKRIYLLAEGRLVNLAAAEGHPSEVMDLSFSNQALSVKYIYENRGKLENKVYNVPQEIDETVAKLKLNGMGIEIEPM
TQEQIEYMKQWRYGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=413, Percent_Identity=47.4576271186441, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=47.8149100257069, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI298286489, Length=413, Percent_Identity=40.4358353510896, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI195539349, Length=413, Percent_Identity=40.4358353510896, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI24308043, Length=413, Percent_Identity=40.4358353510896, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI195539337, Length=413, Percent_Identity=40.4358353510896, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI21361647, Length=413, Percent_Identity=38.9830508474576, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17506425, Length=415, Percent_Identity=43.6144578313253, Blast_Score=338, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6320882, Length=428, Percent_Identity=45.7943925233645, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24642172, Length=412, Percent_Identity=46.8446601941748, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24656245, Length=414, Percent_Identity=39.6135265700483, Blast_Score=297, Evalue=8e-81,
Organism=Drosophila melanogaster, GI45553385, Length=412, Percent_Identity=40.2912621359223, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI45553387, Length=412, Percent_Identity=40.2912621359223, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_SULTO (Q975T0)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376210.1
- ProteinModelPortal:   Q975T0
- SMR:   Q975T0
- GeneID:   1458257
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0342
- NMPDR:   fig|273063.1.peg.378
- HOGENOM:   HBG352029
- OMA:   RTESEKE
- ProtClustDB:   PRK05476
- BioCyc:   STOK273063:ST0342-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 46208; Mature: 46208

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 53-53 BINDING 124-124 BINDING 147-147 BINDING 177-177 BINDING 181-181 BINDING 182-182 BINDING 234-234 BINDING 269-269 BINDING 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKVKDLSLAEQGKKQIEWAEIHMPALMEIRKQFEKEKPLQGLRISAVLHVTKETAVLV
CCCEECCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHEEEE
KTLKIGGATVALAGSNPLSTQDDVAAALVEEGIRVFAWRGETEKDYYDNIKEILKYEPQI
EEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEE
IMDDGGDLHAYVHENMPQLKLFGGTEETTTGVIRLKAMEEQGVLRYPVIAVNNAFTKYLF
EEECCCCEEEEEECCCCCEEEECCCCCCCEEEEEEEEECCCCCEEEEEEEECCHHHHHHH
DNRIGTGQSTIDGILRATNILIAGKVAVVAGYGWVGRGIAQRLRGMGARVIVVEVSPLRA
HCCCCCCHHHHHHHHHHHHEEEECCEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCHHH
LEAVMDGFDVMPMSKAAELGEIFITATGNINVIRKEHILKMKDGAILANSGHFNVEIDVK
HHHHHCCCCCCCCHHHCCCCEEEEEECCCEEEEEHHHEEEECCCEEEECCCEEEEEEEHH
GLKEMAKSSRLIRPNLEEYELPNGKRIYLLAEGRLVNLAAAEGHPSEVMDLSFSNQALSV
HHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEECCCEEEE
KYIYENRGKLENKVYNVPQEIDETVAKLKLNGMGIEIEPMTQEQIEYMKQWRYGT
EEEECCCCCHHHHHHCCCHHHHHHHHHEEECCCCEEECCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MDYKVKDLSLAEQGKKQIEWAEIHMPALMEIRKQFEKEKPLQGLRISAVLHVTKETAVLV
CCCEECCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHEEEE
KTLKIGGATVALAGSNPLSTQDDVAAALVEEGIRVFAWRGETEKDYYDNIKEILKYEPQI
EEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEE
IMDDGGDLHAYVHENMPQLKLFGGTEETTTGVIRLKAMEEQGVLRYPVIAVNNAFTKYLF
EEECCCCEEEEEECCCCCEEEECCCCCCCEEEEEEEEECCCCCEEEEEEEECCHHHHHHH
DNRIGTGQSTIDGILRATNILIAGKVAVVAGYGWVGRGIAQRLRGMGARVIVVEVSPLRA
HCCCCCCHHHHHHHHHHHHEEEECCEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCHHH
LEAVMDGFDVMPMSKAAELGEIFITATGNINVIRKEHILKMKDGAILANSGHFNVEIDVK
HHHHHCCCCCCCCHHHCCCCEEEEEECCCEEEEEHHHEEEECCCEEEECCCEEEEEEEHH
GLKEMAKSSRLIRPNLEEYELPNGKRIYLLAEGRLVNLAAAEGHPSEVMDLSFSNQALSV
HHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEECCCEEEE
KYIYENRGKLENKVYNVPQEIDETVAKLKLNGMGIEIEPMTQEQIEYMKQWRYGT
EEEECCCCCHHHHHHCCCHHHHHHHHHEEECCCCEEECCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479