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The map label for this gene is hpsA [H]

Identifier: 15920421

GI number: 15920421

Start: 259291

End: 259962

Strand: Direct

Name: hpsA [H]

Synonym: ST0238

Alternate gene names: 15920421

Gene position: 259291-259962 (Clockwise)

Preceding gene: 15920419

Following gene: 15920422

Centisome position: 9.62

GC content: 33.04

Gene sequence:

>672_bases
ATGATGGAATTACTGGAAAAATTATTAAAAAGTAAAAATTTACAAGTAGCATTAGATTTTATCGATTTAAAAAACGCAGA
AGAAATTGCAAAACAGTCTATTGAGGCTGGGGCTGATATATTAGAAGTTGGAACACCTTTAATCAAGTCTTATGGCATAC
AAGGAATAAGAAGAATAAGGGAAATTGCAAAAGAAAGAATTGTTTTAGCTGACACTAAAACTGCAGATGCTGGCGACGTA
GAGGCTGAAATAGTTCATCTAGGTGGAGGTAATATTATGACAGTGCTTGGAATTATGGACGATGCTACAATAGAAAGTGC
AGTAAAGAAAGCACATGAATATGGAATTCTCGTCCAAGCAGATCTCATAAACGTTAAAGATATTCTAAAACGAGCAGAAG
AAATTAAAAGATTGGGGGTAGACATAATAGGATTGCATGTAGGATTAGATGTGCAGAAAAAAAGAGGTATTACTATAAGC
GATTTAAAGAATGAAATAAAGAAAGTTAGCGAACTTGGAGTAATAGTATCAGTTGCTGGCGGGTTAAACAAGAATAATAT
TGTTGATATTATAGATTTACCTATAAATATTTATGTTGTTGGTGGAGCAATAACAAGAGCGAAGAATCCATTAGAGGAAG
CTAAGCAAATCGTTAAAATAATTAAGGGGTAA

Upstream 100 bases:

>100_bases
TATAATATACTTTGTCAATCGGAAATCACAGCTAAAAATATCACACAGTGAGTTTTAAAAATCATTTGTTAACTTTTATG
TAGAAATACCTATTGGTGGA

Downstream 100 bases:

>100_bases
AATGAGAATTATAAAGGAGTGATTAAATGTCTCAGCCAGGACAGACTAAATCAAAAGAGCTTAAACTCACATCTAAACAA
GTATTTACTCCAGATTCATT

Product: hexulose-6-phosphate synthase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MMELLEKLLKSKNLQVALDFIDLKNAEEIAKQSIEAGADILEVGTPLIKSYGIQGIRRIREIAKERIVLADTKTADAGDV
EAEIVHLGGGNIMTVLGIMDDATIESAVKKAHEYGILVQADLINVKDILKRAEEIKRLGVDIIGLHVGLDVQKKRGITIS
DLKNEIKKVSELGVIVSVAGGLNKNNIVDIIDLPINIYVVGGAITRAKNPLEEAKQIVKIIKG

Sequences:

>Translated_223_residues
MMELLEKLLKSKNLQVALDFIDLKNAEEIAKQSIEAGADILEVGTPLIKSYGIQGIRRIREIAKERIVLADTKTADAGDV
EAEIVHLGGGNIMTVLGIMDDATIESAVKKAHEYGILVQADLINVKDILKRAEEIKRLGVDIIGLHVGLDVQKKRGITIS
DLKNEIKKVSELGVIVSVAGGLNKNNIVDIIDLPINIYVVGGAITRAKNPLEEAKQIVKIIKG
>Mature_223_residues
MMELLEKLLKSKNLQVALDFIDLKNAEEIAKQSIEAGADILEVGTPLIKSYGIQGIRRIREIAKERIVLADTKTADAGDV
EAEIVHLGGGNIMTVLGIMDDATIESAVKKAHEYGILVQADLINVKDILKRAEEIKRLGVDIIGLHVGLDVQKKRGITIS
DLKNEIKKVSELGVIVSVAGGLNKNNIVDIIDLPINIYVVGGAITRAKNPLEEAKQIVKIIKG

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=209, Percent_Identity=30.1435406698565, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790006, Length=205, Percent_Identity=30.2439024390244, Blast_Score=80, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR017120
- InterPro:   IPR001754
- InterPro:   IPR011060
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6; PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 24169; Mature: 24169

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMELLEKLLKSKNLQVALDFIDLKNAEEIAKQSIEAGADILEVGTPLIKSYGIQGIRRIR
CHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHCHHHHHHHCHHHHHHHH
EIAKERIVLADTKTADAGDVEAEIVHLGGGNIMTVLGIMDDATIESAVKKAHEYGILVQA
HHHHCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEHHCCHHHHHHHHHHHHCCEEEEE
DLINVKDILKRAEEIKRLGVDIIGLHVGLDVQKKRGITISDLKNEIKKVSELGVIVSVAG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHEEEECC
GLNKNNIVDIIDLPINIYVVGGAITRAKNPLEEAKQIVKIIKG
CCCCCCEEEEEECCEEEEEECCHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMELLEKLLKSKNLQVALDFIDLKNAEEIAKQSIEAGADILEVGTPLIKSYGIQGIRRIR
CHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHCHHHHHHHCHHHHHHHH
EIAKERIVLADTKTADAGDVEAEIVHLGGGNIMTVLGIMDDATIESAVKKAHEYGILVQA
HHHHCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEHHCCHHHHHHHHHHHHCCEEEEE
DLINVKDILKRAEEIKRLGVDIIGLHVGLDVQKKRGITISDLKNEIKKVSELGVIVSVAG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHEEEECC
GLNKNNIVDIIDLPINIYVVGGAITRAKNPLEEAKQIVKIIKG
CCCCCCEEEEEECCEEEEEECCHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA