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The map label for this gene is bla [H]

Identifier: 15893167

GI number: 15893167

Start: 1150266

End: 1150538

Strand: Reverse

Name: bla [H]

Synonym: RC1244

Alternate gene names: 15893167

Gene position: 1150538-1150266 (Counterclockwise)

Preceding gene: 15893168

Following gene: 15893166

Centisome position: 90.68

GC content: 30.4

Gene sequence:

>273_bases
ATGAAAATTATAAAACAAGAAGGTAATTGTGAGTCTCGTTATGCTCCATGCTCAACATTTAAAATTGCTATAAGTTTAAT
GGGTTATGATGATGGGTTTTTAATTGATGAAACTCATCCAAAATTACCTGTTAAAGAAGGATATGCTGACTATCTTGAAG
TTTGGAAACAATCCCAAACACCTAAAGATTGGATGAAGAATAGCTGTGTTTGGTATTCTCAGATTATTACTAAAGAATTA
GGTATGGAAAAATTTCGTGATTATGTAACATAA

Upstream 100 bases:

>100_bases
CTATTTTTATTTGAACCTATGAAAAAAATTATTTTATATCTCACTGCCCTAATATCACTTACTATAACTTTTATAATTCA
AGCGGATTGTTTTTTAGTTA

Downstream 100 bases:

>100_bases
TGTGATTATGGTAATCGTGATATTTCAGGAGGAGATAAAGGAAGGAATAACGGTTTAACTAATTCATGGCTTTCTAGTTC
TTTAGAAATTTCACCGTAAG

Product: putative beta-lactamase

Products: NA

Alternate protein names: Penicillinase [H]

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MKIIKQEGNCESRYAPCSTFKIAISLMGYDDGFLIDETHPKLPVKEGYADYLEVWKQSQTPKDWMKNSCVWYSQIITKEL
GMEKFRDYVT

Sequences:

>Translated_90_residues
MKIIKQEGNCESRYAPCSTFKIAISLMGYDDGFLIDETHPKLPVKEGYADYLEVWKQSQTPKDWMKNSCVWYSQIITKEL
GMEKFRDYVT
>Mature_90_residues
MKIIKQEGNCESRYAPCSTFKIAISLMGYDDGFLIDETHPKLPVKEGYADYLEVWKQSQTPKDWMKNSCVWYSQIITKEL
GMEKFRDYVT

Specific function: Has a broad substrate profile, hydrolyzes amoxicillin, ticarcillin, cephalothin, ceftazidime, cefotaxime, and aztreonam, but not imipenem or cephamycins [H]

COG id: COG2602

COG function: function code V; Beta-lactamase class D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-D beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR002137
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 10567; Mature: 10567

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00337 BETA_LACTAMASE_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIKQEGNCESRYAPCSTFKIAISLMGYDDGFLIDETHPKLPVKEGYADYLEVWKQSQT
CCCCCCCCCCCCCCCCCCCEEHEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCC
PKDWMKNSCVWYSQIITKELGMEKFRDYVT
CHHHHHCCCHHHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure
MKIIKQEGNCESRYAPCSTFKIAISLMGYDDGFLIDETHPKLPVKEGYADYLEVWKQSQT
CCCCCCCCCCCCCCCCCCCEEHEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCC
PKDWMKNSCVWYSQIITKELGMEKFRDYVT
CHHHHHCCCHHHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9333046 [H]