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The map label for this gene is fabH

Identifier: 15893125

GI number: 15893125

Start: 1097428

End: 1098384

Strand: Reverse

Name: fabH

Synonym: RC1202

Alternate gene names: 15893125

Gene position: 1098384-1097428 (Counterclockwise)

Preceding gene: 15893126

Following gene: 15893123

Centisome position: 86.57

GC content: 36.05

Gene sequence:

>957_bases
ATGACCTGTAAAATTATTGGTTGCGGCGGGTATCTTCCTTCAAAAATAGTTAGTAATGACGAGCTTGCAAAATTCGTAGA
TACTAACGATGAATGGATTAGAACAAGAACAGGTATTACGCAGCGTCATATAGCAGGTGATACAGAATATACTTCCCATC
TTGCTTTAAAATCAGCTGAAAAAGCTATAGCAGATGCAGGGATATCGGTAAATGATATTGATTTAATTATTACATGTACT
ACTACTCCCGATAATAGCTTCCCTTCGGTTGCCTCTAAGCTTCAAGGTTATCTTGGTTTAACTAATATACCGTCTTTTGA
TTTACAAGCAGTATGTGCCGGCTTTGTTTATGGTTTACAAGTAGCAAATTCTCTTATCTCATCAGATAAATATAAAACTA
TTTTGCTTATAGGAGCCGAGAAAATGACGTCGTTATTAGATTGGAATGATAGGACTACTTGCGTTTTATTCGGTGATGGG
GCCGGTAGCGTAATATTACAGCGTAGTAGTGATGATTCCGGTTTGATAGATAGTAATATCTTCTCAAGCGGGGCTGATTA
TGATGAAATATTATACACAAACGGTGGTGTAAGTATGAACGGTATTAGTGGCAAAATAGTTATGCAGGGGCAAAAATTAT
TTCGTCATGCAATAGAAAAAATGCAACAATCTATAAAAGATTTACTGCATGCTAATCAATTCAGTGTAAGCGATATTGAT
TATTTTATACCTCATCAAGCAAATATCCGTATTATAAATAAACTCGCTGAACTATTAAATATAGAAGAGCATAAAGTAGT
GAAAACCGTAGACAAACATGCTAACTGCTCTGCTGCTTCTATTCCGCTTGCTTTGAGTACTCTCAAAGCATCAGGCAAAA
TAAAAAAAGGTGATATTCTACTATTTTCAGCTATCGGTGCAGGTCTTACTTGGGGCAGTGCATTCATTAGATGGTGA

Upstream 100 bases:

>100_bases
AAGCTTCCGCATCACGTTTCTTTAGTCGACGGTACTTATAATAATCGTCTAGTAGTAACAAAGAAAATTAAAACTGAAGA
AGAAGTAGCCTAAAAGATTT

Downstream 100 bases:

>100_bases
ATATACTCGTTGTATTACATCTTCGGAAACTCTACTACTAGAGGTAATTTGTACGTTGATCCTGTACTCGAATCCTCACG
TACCTCTATGTACGCTGCGG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTCKIIGCGGYLPSKIVSNDELAKFVDTNDEWIRTRTGITQRHIAGDTEYTSHLALKSAEKAIADAGISVNDIDLIITCT
TTPDNSFPSVASKLQGYLGLTNIPSFDLQAVCAGFVYGLQVANSLISSDKYKTILLIGAEKMTSLLDWNDRTTCVLFGDG
AGSVILQRSSDDSGLIDSNIFSSGADYDEILYTNGGVSMNGISGKIVMQGQKLFRHAIEKMQQSIKDLLHANQFSVSDID
YFIPHQANIRIINKLAELLNIEEHKVVKTVDKHANCSAASIPLALSTLKASGKIKKGDILLFSAIGAGLTWGSAFIRW

Sequences:

>Translated_318_residues
MTCKIIGCGGYLPSKIVSNDELAKFVDTNDEWIRTRTGITQRHIAGDTEYTSHLALKSAEKAIADAGISVNDIDLIITCT
TTPDNSFPSVASKLQGYLGLTNIPSFDLQAVCAGFVYGLQVANSLISSDKYKTILLIGAEKMTSLLDWNDRTTCVLFGDG
AGSVILQRSSDDSGLIDSNIFSSGADYDEILYTNGGVSMNGISGKIVMQGQKLFRHAIEKMQQSIKDLLHANQFSVSDID
YFIPHQANIRIINKLAELLNIEEHKVVKTVDKHANCSAASIPLALSTLKASGKIKKGDILLFSAIGAGLTWGSAFIRW
>Mature_317_residues
TCKIIGCGGYLPSKIVSNDELAKFVDTNDEWIRTRTGITQRHIAGDTEYTSHLALKSAEKAIADAGISVNDIDLIITCTT
TPDNSFPSVASKLQGYLGLTNIPSFDLQAVCAGFVYGLQVANSLISSDKYKTILLIGAEKMTSLLDWNDRTTCVLFGDGA
GSVILQRSSDDSGLIDSNIFSSGADYDEILYTNGGVSMNGISGKIVMQGQKLFRHAIEKMQQSIKDLLHANQFSVSDIDY
FIPHQANIRIINKLAELLNIEEHKVVKTVDKHANCSAASIPLALSTLKASGKIKKGDILLFSAIGAGLTWGSAFIRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=40.4388714733542, Blast_Score=258, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_RICCN (Q92GC1)

Other databases:

- EMBL:   AE006914
- PIR:   B97850
- RefSeq:   NP_360839.1
- ProteinModelPortal:   Q92GC1
- SMR:   Q92GC1
- GeneID:   928349
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC1202
- OMA:   SSGADYE
- ProtClustDB:   PRK09352
- BioCyc:   RCON272944:RC1202-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34401; Mature: 34269

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 245-245 ACT_SITE 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCKIIGCGGYLPSKIVSNDELAKFVDTNDEWIRTRTGITQRHIAGDTEYTSHLALKSAE
CEEEEEEECCCCCHHHCCCCHHHHHHCCCCHHEEHHCCCCHHHCCCCCCHHHHHHHHHHH
KAIADAGISVNDIDLIITCTTTPDNSFPSVASKLQGYLGLTNIPSFDLQAVCAGFVYGLQ
HHHHHCCCCEECEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VANSLISSDKYKTILLIGAEKMTSLLDWNDRTTCVLFGDGAGSVILQRSSDDSGLIDSNI
HHHHHHCCCCCEEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCHH
FSSGADYDEILYTNGGVSMNGISGKIVMQGQKLFRHAIEKMQQSIKDLLHANQFSVSDID
HCCCCCCCCEEEECCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
YFIPHQANIRIINKLAELLNIEEHKVVKTVDKHANCSAASIPLALSTLKASGKIKKGDIL
EECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCEECCCEE
LFSAIGAGLTWGSAFIRW
EEEECCCCCCCCHHHCCC
>Mature Secondary Structure 
TCKIIGCGGYLPSKIVSNDELAKFVDTNDEWIRTRTGITQRHIAGDTEYTSHLALKSAE
EEEEEEECCCCCHHHCCCCHHHHHHCCCCHHEEHHCCCCHHHCCCCCCHHHHHHHHHHH
KAIADAGISVNDIDLIITCTTTPDNSFPSVASKLQGYLGLTNIPSFDLQAVCAGFVYGLQ
HHHHHCCCCEECEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VANSLISSDKYKTILLIGAEKMTSLLDWNDRTTCVLFGDGAGSVILQRSSDDSGLIDSNI
HHHHHHCCCCCEEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCHH
FSSGADYDEILYTNGGVSMNGISGKIVMQGQKLFRHAIEKMQQSIKDLLHANQFSVSDID
HCCCCCCCCEEEECCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
YFIPHQANIRIINKLAELLNIEEHKVVKTVDKHANCSAASIPLALSTLKASGKIKKGDIL
EECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCEECCCEE
LFSAIGAGLTWGSAFIRW
EEEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893