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The map label for this gene is pccB [H]

Identifier: 15892883

GI number: 15892883

Start: 899164

End: 900708

Strand: Reverse

Name: pccB [H]

Synonym: RC0960

Alternate gene names: 15892883

Gene position: 900708-899164 (Counterclockwise)

Preceding gene: 15892886

Following gene: 15892882

Centisome position: 70.99

GC content: 40.26

Gene sequence:

>1545_bases
ATGAATCAAAGTAATATAATCTCTCCTGAGTTATTGGATGAGAGAAGAAATATTGCAAGGCAAGGGGGCGGTGAAGCTAG
GATCAACGCACAACATCAAAAAGGTAAGTTAACTGCACGAGAACGCATAGAAGTATTATTAGATCCGAATAGCTTTACCG
AAACAGGTATGTTTGTATCCCATAGATGCGATAATTTTGGGATGCAGGATAAAAAGTTTTTAGGTGACGGCGTTGTAACG
GGACACGGTACGATAAACGGTAGGTTGGTATTTATTTATAGCCAAGATTTTACCGTACTCGGCGGCTCTCTCGGTGAATA
TCATGCTAAGAAAATCTGTGATATTATCGATCAAGCTATAGAAACCGGTGCTCCCGTAATCGGTATTAACGACTCAGGGG
GAGCAAGAATTCAAGAAGGGGTTGATGCTCTGGCCGGATACGGTGAATTATTTCAGCGTAATGTTTTAGCGTCGGGTGTC
ATCCCTCAAATTACCCTAATTATGGGCCCTTGTGCCGGTGGTGCGGTATATTCTCCTGCCTTAACCGATTTTATATTTAT
GGTTAAGAATAGTTCTTATATGTTCGTAACTGGTCCCGATGTAGTAAAAACCGTTACGGGTGAAGAAGTAAGCCAAGAAA
AGCTCGGCGGTGCTAGGATGCATACCACTAAAAGCGGCGTTGCCGATCTTGCATTTAACAATGATATAGAAGCATTGCTT
GAAATTCGTAAATTCTTTAATTTCCTTCCGTCATCCAATCGTAGTCCTCTTCCTGTTCGTTCGACTGTTGATCCTGCCGA
TAGAGTGGATATGTCTCTTAGTACGTTAATACCTAACACTCCTAATAAGCCTTATGATATGAAAGAGCTTGTTGAGCGTA
TCGTTGATGAGGGAGAATTTTTTGAACTACAACCTGATTTTGCTAAGAATATCATTATTGGCTTTGGTTATATGGAAGGT
TATCCGGTAGGATTTGTGGCTAATCAGCCTTTGCATTTAGCAGGATGTTTAGATATAAACGCCTCAAGAAAAGCAGCAAG
ATTTGTTAGATTTTGTGATGCTTTCAATATTCCTATAGTAAGTCTTGTTGATGTGCCTGGATTTCTGCCTGGTACATCCC
AAGAGCATGATGGTATTATTAAACACGGGGCTAAGCTGTTATACGCTTATGCGGAAGCTACAGTGCCGAAGATTACTGTA
ATTACCCGTAAGGCTTATGGAGGTGCTTATATAGTTATGAACTCCAAGCATCTTAGAGGTGATATAAACTATGCTTGGTT
TAATTCGGAAATCGCTGTTATGGGGGCAGAGGGAGCAGCAGAGATAATATTTAAGGAAGAATGTAAAAACCCTGAAGCTA
AAAAACAAAAAATCGATGAATATAGGCAAGTAGTAACTTCGCCTTTTGTTGCGGCATCTAGGGGATATTTGGATGATATT
ATAAGACCGCAAAATACCAGATGGCGAATATGTAAGGCGTTAAATTTTCTGCGTACTAAAAAAGTAGAACTGCCTTGGAA
GAAGCATGATAATTTGCCGCTTTAG

Upstream 100 bases:

>100_bases
CTTTGATATAGTTGGTAGATGACATAAATAATTATCTTTTCACATTAGCATTATTATATTATATTATGGATATTTTGGAA
AATAAAACTATAAATAATCT

Downstream 100 bases:

>100_bases
CTGTCATCCCGTGGCGTGACCATGGGATCTCAGAATACAGCCTGTGACACAAGACCCCGTGGTCAAGCCACGGGGTGACA
TTAGGATATAAAAAACTATG

Product: propionyl-CoA carboxylase beta chain precursor

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MNQSNIISPELLDERRNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVSHRCDNFGMQDKKFLGDGVVT
GHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAIETGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGV
IPQITLIMGPCAGGAVYSPALTDFIFMVKNSSYMFVTGPDVVKTVTGEEVSQEKLGGARMHTTKSGVADLAFNNDIEALL
EIRKFFNFLPSSNRSPLPVRSTVDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEFFELQPDFAKNIIIGFGYMEG
YPVGFVANQPLHLAGCLDINASRKAARFVRFCDAFNIPIVSLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITV
ITRKAYGGAYIVMNSKHLRGDINYAWFNSEIAVMGAEGAAEIIFKEECKNPEAKKQKIDEYRQVVTSPFVAASRGYLDDI
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL

Sequences:

>Translated_514_residues
MNQSNIISPELLDERRNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVSHRCDNFGMQDKKFLGDGVVT
GHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAIETGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGV
IPQITLIMGPCAGGAVYSPALTDFIFMVKNSSYMFVTGPDVVKTVTGEEVSQEKLGGARMHTTKSGVADLAFNNDIEALL
EIRKFFNFLPSSNRSPLPVRSTVDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEFFELQPDFAKNIIIGFGYMEG
YPVGFVANQPLHLAGCLDINASRKAARFVRFCDAFNIPIVSLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITV
ITRKAYGGAYIVMNSKHLRGDINYAWFNSEIAVMGAEGAAEIIFKEECKNPEAKKQKIDEYRQVVTSPFVAASRGYLDDI
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL
>Mature_514_residues
MNQSNIISPELLDERRNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVSHRCDNFGMQDKKFLGDGVVT
GHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAIETGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGV
IPQITLIMGPCAGGAVYSPALTDFIFMVKNSSYMFVTGPDVVKTVTGEEVSQEKLGGARMHTTKSGVADLAFNNDIEALL
EIRKFFNFLPSSNRSPLPVRSTVDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEFFELQPDFAKNIIIGFGYMEG
YPVGFVANQPLHLAGCLDINASRKAARFVRFCDAFNIPIVSLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITV
ITRKAYGGAYIVMNSKHLRGDINYAWFNSEIAVMGAEGAAEIIFKEECKNPEAKKQKIDEYRQVVTSPFVAASRGYLDDI
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=64.8915187376726, Blast_Score=682, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=62.4288425047438, Blast_Score=670, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=493, Percent_Identity=32.8600405679513, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI134142062, Length=399, Percent_Identity=25.31328320802, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679960, Length=397, Percent_Identity=25.4408060453401, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI38679977, Length=397, Percent_Identity=24.6851385390428, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI38679967, Length=397, Percent_Identity=24.6851385390428, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI38679974, Length=397, Percent_Identity=24.6851385390428, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI38679971, Length=397, Percent_Identity=24.6851385390428, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1788655, Length=195, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=62.624254473161, Blast_Score=676, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=62.624254473161, Blast_Score=676, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=509, Percent_Identity=32.4165029469548, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24586065, Length=514, Percent_Identity=33.852140077821, Blast_Score=235, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56690; Mature: 56690

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSNIISPELLDERRNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVS
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHH
HRCDNFGMQDKKFLGDGVVTGHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAI
HCCCCCCCCCHHHHCCCEEECCCEECCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
ETGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGVIPQITLIMGPCAGGAVYSPA
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
LTDFIFMVKNSSYMFVTGPDVVKTVTGEEVSQEKLGGARMHTTKSGVADLAFNNDIEALL
HHHEEEEEECCCEEEEECCHHHEECCCCHHHHHHCCCCEEEECCCCCEEEECCCCHHHHH
EIRKFFNFLPSSNRSPLPVRSTVDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEF
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCE
FELQPDFAKNIIIGFGYMEGYPVGFVANQPLHLAGCLDINASRKAARFVRFCDAFNIPIV
EEECCHHHCCEEEEECCCCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEE
SLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITVITRKAYGGAYIVMNSKHLRG
EEECCCCCCCCCCCCCCCHHHHHHHHEEHHHHCCCCEEEEEEEECCCCEEEEECCCCCCC
DINYAWFNSEIAVMGAEGAAEIIFKEECKNPEAKKQKIDEYRQVVTSPFVAASRGYLDDI
CCEEEEECCEEEEEECCCCHHHEEHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHH
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL
CCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure
MNQSNIISPELLDERRNIARQGGGEARINAQHQKGKLTARERIEVLLDPNSFTETGMFVS
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHH
HRCDNFGMQDKKFLGDGVVTGHGTINGRLVFIYSQDFTVLGGSLGEYHAKKICDIIDQAI
HCCCCCCCCCHHHHCCCEEECCCEECCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
ETGAPVIGINDSGGARIQEGVDALAGYGELFQRNVLASGVIPQITLIMGPCAGGAVYSPA
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
LTDFIFMVKNSSYMFVTGPDVVKTVTGEEVSQEKLGGARMHTTKSGVADLAFNNDIEALL
HHHEEEEEECCCEEEEECCHHHEECCCCHHHHHHCCCCEEEECCCCCEEEECCCCHHHHH
EIRKFFNFLPSSNRSPLPVRSTVDPADRVDMSLSTLIPNTPNKPYDMKELVERIVDEGEF
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCE
FELQPDFAKNIIIGFGYMEGYPVGFVANQPLHLAGCLDINASRKAARFVRFCDAFNIPIV
EEECCHHHCCEEEEECCCCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEE
SLVDVPGFLPGTSQEHDGIIKHGAKLLYAYAEATVPKITVITRKAYGGAYIVMNSKHLRG
EEECCCCCCCCCCCCCCCHHHHHHHHEEHHHHCCCCEEEEEEEECCCCEEEEECCCCCCC
DINYAWFNSEIAVMGAEGAAEIIFKEECKNPEAKKQKIDEYRQVVTSPFVAASRGYLDDI
CCEEEEECCEEEEEECCCCHHHEEHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHH
IRPQNTRWRICKALNFLRTKKVELPWKKHDNLPL
CCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]