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The map label for this gene is rickA [H]

Identifier: 15892832

GI number: 15892832

Start: 852642

End: 854204

Strand: Reverse

Name: rickA [H]

Synonym: RC0909

Alternate gene names: 15892832

Gene position: 854204-852642 (Counterclockwise)

Preceding gene: 15892833

Following gene: 15892826

Centisome position: 67.33

GC content: 31.8

Gene sequence:

>1563_bases
GTGTATGGCATGGTTAAAGAAATAGATATAAATAAATTATTAGCACAAGAAAATAATGCTTTAAATACTATATTGAGCCA
AGTAAATGAATTATGCAAACAAAATAAGCAGTTGCAAGGTTTAATCGAAATACAAAATGAAACTAAAGAACTAGAAAAAG
AACATAATAGATCGTTGCCTTGGTTTAAAAGATTTGTAAAAACAGTTTCTAATGTAAAGTATATTTTGATAAAAAGTGAA
GAACAGTTAACAAATGAAGCAATAAAGTATAATAATAAAATATTAAAAGATATTGATAATAAGATATATAATATAGCGGA
AAAATCTGCACCTTTAAAGCAAGCATTACAAGAAGAAATCGAAAAAAATTTTAAGGATTTAACAAAGAAAGATTTATCTA
AAGATCAAAGAGCAAGATTATCGGAAGTATTTTTTAGTTATAAGAGTAAACCTGAAAGATTCTCAGCTCTACATATGACA
AATCCCTTACAATTCATTAATGCTGAAGCACTAGAGAAACAATATAATTCTTTAAATGCTACAAAACAAAACATCCAAAA
TTTAATATCCGCAAATTCTAATATCAAAGAACTTAAAGAAATACAAAAACAGGTTGCTGAAATTAGGGCAGAAGTACCTC
ATACATTTTTTGAAAAATTAAATAATATTTGGCAAAATGTTAAAAATGTTTTTGTAAATAATAGTGAGCAGGTTTTAGCA
AAAAACAAAGAGAGTAATACTAGAACAATTAGAAAGATTGATGAACAATTATATAAAACGAAGCATAAATTTGAGGAATT
AATTGAAAATAAAGAAAGAAATATTAAGGATATAATTGCAAAATTACCTGACAATGAGAAGTTACAAAAGATAGTAAGTA
ACCTTACAAATCACATGGCTTCACAAAAAGAACCAATATTAGCAAATGCGTCCCTAGCTAAACCTTTGGAAAATAATATA
ACACCACCGTCTCCTTTACCGGAAAATAACATTCCATCACCACCTCCACCTCCACCACCGTCTCCTTTACCGGAAAATAA
CATTCCATCATCACCTCCACCTCCACCACCGCCTCCTTTACCGGAAAATAACATTCCATCACCACCTCCACCTCCACCTC
CACCTCCACCACCGCCTATGGCTCCGGCTCAGGCTGAGACATTATCTAAGCCTATAGAATCTACTACGGTTAAAAAACTG
GCAAATCAACCACGTCCTTCTATAGATACTTCTGATTTAATGAGAGAAATAGCAGGGCCAAAAAAACTAAAAAAAGTTGA
ATTTGACCCTAATACAGGAAAACCGGTTGCACATTCTCATAGTAAGCCTGCTCAGAATGTTAACGCACTTAGTGGACTTG
AATCAATTTTCGCACGAAGAGCTGTTATAAAGGTGAGTGATAGTAGTAGCAGTGAAAGCGATAGTGGTAACTGGAGTGAT
GTTAGTGTTAATAGGAATAAATCAAAAATGCTTAAAACTAAAGGAGAACGAGATGCTAAAATGACTACGCATGCTCAAAA
AATTAATAATAGGAACTCACAAAACCCATCATTTGTTAGATAA

Upstream 100 bases:

>100_bases
TTTATCTATCTTTTATTTATCAAAATACATTACATAAATTAACTTTCTCTTTGCTTTTGTACAAGAAATTTGCTATAATA
CTGATATTAATTTATATTAG

Downstream 100 bases:

>100_bases
TAAATGTCATTCCCGCTTTGCGGGAATGACATAAAACACCATATAAATCTACCCTTTAAACTTCTTAGTTATTTCAACTA
TTCTTTTACCAAAGAAATTA

Product: putative WASP, N-WASP, MENA proteins

Products: NA

Alternate protein names: Actin polymerization protein rickA [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MYGMVKEIDINKLLAQENNALNTILSQVNELCKQNKQLQGLIEIQNETKELEKEHNRSLPWFKRFVKTVSNVKYILIKSE
EQLTNEAIKYNNKILKDIDNKIYNIAEKSAPLKQALQEEIEKNFKDLTKKDLSKDQRARLSEVFFSYKSKPERFSALHMT
NPLQFINAEALEKQYNSLNATKQNIQNLISANSNIKELKEIQKQVAEIRAEVPHTFFEKLNNIWQNVKNVFVNNSEQVLA
KNKESNTRTIRKIDEQLYKTKHKFEELIENKERNIKDIIAKLPDNEKLQKIVSNLTNHMASQKEPILANASLAKPLENNI
TPPSPLPENNIPSPPPPPPPSPLPENNIPSSPPPPPPPPLPENNIPSPPPPPPPPPPPPMAPAQAETLSKPIESTTVKKL
ANQPRPSIDTSDLMREIAGPKKLKKVEFDPNTGKPVAHSHSKPAQNVNALSGLESIFARRAVIKVSDSSSSESDSGNWSD
VSVNRNKSKMLKTKGERDAKMTTHAQKINNRNSQNPSFVR

Sequences:

>Translated_520_residues
MYGMVKEIDINKLLAQENNALNTILSQVNELCKQNKQLQGLIEIQNETKELEKEHNRSLPWFKRFVKTVSNVKYILIKSE
EQLTNEAIKYNNKILKDIDNKIYNIAEKSAPLKQALQEEIEKNFKDLTKKDLSKDQRARLSEVFFSYKSKPERFSALHMT
NPLQFINAEALEKQYNSLNATKQNIQNLISANSNIKELKEIQKQVAEIRAEVPHTFFEKLNNIWQNVKNVFVNNSEQVLA
KNKESNTRTIRKIDEQLYKTKHKFEELIENKERNIKDIIAKLPDNEKLQKIVSNLTNHMASQKEPILANASLAKPLENNI
TPPSPLPENNIPSPPPPPPPSPLPENNIPSSPPPPPPPPLPENNIPSPPPPPPPPPPPPMAPAQAETLSKPIESTTVKKL
ANQPRPSIDTSDLMREIAGPKKLKKVEFDPNTGKPVAHSHSKPAQNVNALSGLESIFARRAVIKVSDSSSSESDSGNWSD
VSVNRNKSKMLKTKGERDAKMTTHAQKINNRNSQNPSFVR
>Mature_520_residues
MYGMVKEIDINKLLAQENNALNTILSQVNELCKQNKQLQGLIEIQNETKELEKEHNRSLPWFKRFVKTVSNVKYILIKSE
EQLTNEAIKYNNKILKDIDNKIYNIAEKSAPLKQALQEEIEKNFKDLTKKDLSKDQRARLSEVFFSYKSKPERFSALHMT
NPLQFINAEALEKQYNSLNATKQNIQNLISANSNIKELKEIQKQVAEIRAEVPHTFFEKLNNIWQNVKNVFVNNSEQVLA
KNKESNTRTIRKIDEQLYKTKHKFEELIENKERNIKDIIAKLPDNEKLQKIVSNLTNHMASQKEPILANASLAKPLENNI
TPPSPLPENNIPSPPPPPPPSPLPENNIPSSPPPPPPPPLPENNIPSPPPPPPPPPPPPMAPAQAETLSKPIESTTVKKL
ANQPRPSIDTSDLMREIAGPKKLKKVEFDPNTGKPVAHSHSKPAQNVNALSGLESIFARRAVIKVSDSSSSESDSGNWSD
VSVNRNKSKMLKTKGERDAKMTTHAQKINNRNSQNPSFVR

Specific function: Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell surface [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 WH2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 58711; Mature: 58711

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGMVKEIDINKLLAQENNALNTILSQVNELCKQNKQLQGLIEIQNETKELEKEHNRSLP
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCH
WFKRFVKTVSNVKYILIKSEEQLTNEAIKYNNKILKDIDNKIYNIAEKSAPLKQALQEEI
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EKNFKDLTKKDLSKDQRARLSEVFFSYKSKPERFSALHMTNPLQFINAEALEKQYNSLNA
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TKQNIQNLISANSNIKELKEIQKQVAEIRAEVPHTFFEKLNNIWQNVKNVFVNNSEQVLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
KNKESNTRTIRKIDEQLYKTKHKFEELIENKERNIKDIIAKLPDNEKLQKIVSNLTNHMA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
SQKEPILANASLAKPLENNITPPSPLPENNIPSPPPPPPPSPLPENNIPSSPPPPPPPPL
HCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PENNIPSPPPPPPPPPPPPMAPAQAETLSKPIESTTVKKLANQPRPSIDTSDLMREIAGP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCH
KKLKKVEFDPNTGKPVAHSHSKPAQNVNALSGLESIFARRAVIKVSDSSSSESDSGNWSD
HHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCC
VSVNRNKSKMLKTKGERDAKMTTHAQKINNRNSQNPSFVR
EECCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYGMVKEIDINKLLAQENNALNTILSQVNELCKQNKQLQGLIEIQNETKELEKEHNRSLP
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCH
WFKRFVKTVSNVKYILIKSEEQLTNEAIKYNNKILKDIDNKIYNIAEKSAPLKQALQEEI
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EKNFKDLTKKDLSKDQRARLSEVFFSYKSKPERFSALHMTNPLQFINAEALEKQYNSLNA
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TKQNIQNLISANSNIKELKEIQKQVAEIRAEVPHTFFEKLNNIWQNVKNVFVNNSEQVLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
KNKESNTRTIRKIDEQLYKTKHKFEELIENKERNIKDIIAKLPDNEKLQKIVSNLTNHMA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
SQKEPILANASLAKPLENNITPPSPLPENNIPSPPPPPPPSPLPENNIPSSPPPPPPPPL
HCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PENNIPSPPPPPPPPPPPPMAPAQAETLSKPIESTTVKKLANQPRPSIDTSDLMREIAGP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCH
KKLKKVEFDPNTGKPVAHSHSKPAQNVNALSGLESIFARRAVIKVSDSSSSESDSGNWSD
HHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCC
VSVNRNKSKMLKTKGERDAKMTTHAQKINNRNSQNPSFVR
EECCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]