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The map label for this gene is uvrC [H]

Identifier: 15892787

GI number: 15892787

Start: 813554

End: 815473

Strand: Reverse

Name: uvrC [H]

Synonym: RC0864

Alternate gene names: 15892787

Gene position: 815473-813554 (Counterclockwise)

Preceding gene: 15892788

Following gene: 15892781

Centisome position: 64.27

GC content: 35.83

Gene sequence:

>1920_bases
ATGACCCTAGAAATTACCGGAAGTGAGTTAATTAAATCTAAACTTATAGATGCTCCTGAACGTTCAGGGGTTTATCGAAT
GTTTGACGTTAACAAGCAAGTTCTCTATGTCGGTAAAGCTAAAAATTTAAAGAAACGCCTTACTAATTACATTAAAAGCA
ATTTAGATAATAAGACGCTTCGGATGATTGCAAATACTTGTTTTTTAGAGTATAGCATCACTAATTCCGAAGTTGAAGCA
CTACTTTTAGAAGCACAGTTAATCAAGAAATTTCAGCCGAAATTTAATATTCTTCTTAAGGACTGCAAGTCTTTTCCTTT
CATTAAGTTACGTTTAGATCATGATTTCCCACAATTACTAAAATATCGAGGTAAAACTCTAAGTGACGGGAAGTTTTTTG
GTCCTTTTGCCTCGAGTGTGGAAGTTAATACTACTTTGACCGAACTACAAAAAATTTTTAAATTACGTTCTTGCACGGAT
AATTACTTTAATTCACGTACTCGCCCTTGCTTACAATATGAAATAAAACGTTGTTATGCTCCTTGCGTCGGTAAAATAAA
CAAGGAAGACTATAGAGACTTAGTAACTCAGGTTAAAGATTTCTTACAAGGTCGCACTAAAGAACTCCAAGAGAACCTAT
CTAGAAAGATGGAAGAGCTAAGTAGTCAGATGCGTTTTGAAGAGGCGGCAGAAATTAGAGATCGCATTAAAGCACTGAGT
TATGTGCAGCTTAAGGCAGGGGTTTCAGATGTCGTTAAAGACGCAGATATAATCGCTATTGTGGAAAAGAACGGGCATTA
TTGCGTGGAAGTGTTTTTATATAGGGCAGGGCAAGCATGCGGTAATATTCCTTATTTTCCTACTGCTACCGAAAATAGTA
CCAAAGAAGAAGTATTAGAATATTTTTTATTACAATTTTACCAAAAACAACACGTGCCTGCGGCAATTATAATTAATCAT
GAAATTAATGATAAAGAGAATGTGATAGAGGCGATTAAGAAAATCAACAATATACTTCAGATTAATATTACAGTACCTAA
TAAAGGCGGTAAGGCTAAATTAGTTCAAAATGCTGAGACACATGCTTTATTTTCTCTAGAGCAGTATTTGAAGAAATTTG
CAAAAAATCAAGAGATTATGTTTGAAATTAAAGAGCTGTTTGGTCTTTCTGAAATTCCTGAAAGAATTGAGATTTATGAT
AATAGCCATATTCAAGGTAAGTTTGCGGTTGGAGTGATGGTAGTTGCTGGTAAAGTCGGTTTTGATAAAAAAGAATATCG
GGTTTTTAATGTCCATACTCCCTCTCTCGTATGTCATTCCCGTGAAAGCGGGGATCCAAAAAGGTTAATGGATTCCTGCT
TTCGTGGGAATGGCATAAAGAACTGCGGGGGTGACATAAAAGGTGACGATTATGAGATGCTCCGGCAAGTCCTAACAAGG
CGGCTTACAAGGTTAAGGCAAGAGCCGCATAAATTGCCAAGCTTAATGATTATAGACGGCGGCAAAGGGCATTTAGGCGT
TGTTAAAGAGGTGATGGATAAATTTGAAATGAATATTCCTTTTGTTTGTATGTCAAAAGGAGTAGATAGAAATGCCGGTT
TTGAACAGTTCCATGTGATAGGTAAGGAAGTATTTACTCTAGATAAGAATTTGCCGGTTATGAAATATTTACAAATCTTG
CGAGATGAGGCACATAATTTTGCCATAAAGAATCATAGACTAGGTAGATCACGTGCTATAAAAATATCACGCCTTGACGA
TATAGAGGGCGTAGGTGAAACTCGAAAAAAAGCATTACTGCATTATTTCGGTTCGTATAAAGCAGTATGCGACGCAACCA
TATATGAGCTTGCTAAAGTAAATGGTATTAACAAGTTACTTGCTGAGATGATTTTTAATGTTTTGCACAGAAAAAACTAA

Upstream 100 bases:

>100_bases
TTGTTTTTTTAGGTTTAATGTGTAATTTTTATATCAATATTAAGGTTATTTTTTCTGGATTTCGGCTTTTAGCTAAGAAT
GACATAGGACCACTATACAC

Downstream 100 bases:

>100_bases
TATTATAACTCATGAAAAACCTAGTTGTATGAGTTGCGATGTCATTCCCGCAGAGGCGGGAATCCAGTCACTAAAAAGTC
TAGACATACTAAATTTAAAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MTLEITGSELIKSKLIDAPERSGVYRMFDVNKQVLYVGKAKNLKKRLTNYIKSNLDNKTLRMIANTCFLEYSITNSEVEA
LLLEAQLIKKFQPKFNILLKDCKSFPFIKLRLDHDFPQLLKYRGKTLSDGKFFGPFASSVEVNTTLTELQKIFKLRSCTD
NYFNSRTRPCLQYEIKRCYAPCVGKINKEDYRDLVTQVKDFLQGRTKELQENLSRKMEELSSQMRFEEAAEIRDRIKALS
YVQLKAGVSDVVKDADIIAIVEKNGHYCVEVFLYRAGQACGNIPYFPTATENSTKEEVLEYFLLQFYQKQHVPAAIIINH
EINDKENVIEAIKKINNILQINITVPNKGGKAKLVQNAETHALFSLEQYLKKFAKNQEIMFEIKELFGLSEIPERIEIYD
NSHIQGKFAVGVMVVAGKVGFDKKEYRVFNVHTPSLVCHSRESGDPKRLMDSCFRGNGIKNCGGDIKGDDYEMLRQVLTR
RLTRLRQEPHKLPSLMIIDGGKGHLGVVKEVMDKFEMNIPFVCMSKGVDRNAGFEQFHVIGKEVFTLDKNLPVMKYLQIL
RDEAHNFAIKNHRLGRSRAIKISRLDDIEGVGETRKKALLHYFGSYKAVCDATIYELAKVNGINKLLAEMIFNVLHRKN

Sequences:

>Translated_639_residues
MTLEITGSELIKSKLIDAPERSGVYRMFDVNKQVLYVGKAKNLKKRLTNYIKSNLDNKTLRMIANTCFLEYSITNSEVEA
LLLEAQLIKKFQPKFNILLKDCKSFPFIKLRLDHDFPQLLKYRGKTLSDGKFFGPFASSVEVNTTLTELQKIFKLRSCTD
NYFNSRTRPCLQYEIKRCYAPCVGKINKEDYRDLVTQVKDFLQGRTKELQENLSRKMEELSSQMRFEEAAEIRDRIKALS
YVQLKAGVSDVVKDADIIAIVEKNGHYCVEVFLYRAGQACGNIPYFPTATENSTKEEVLEYFLLQFYQKQHVPAAIIINH
EINDKENVIEAIKKINNILQINITVPNKGGKAKLVQNAETHALFSLEQYLKKFAKNQEIMFEIKELFGLSEIPERIEIYD
NSHIQGKFAVGVMVVAGKVGFDKKEYRVFNVHTPSLVCHSRESGDPKRLMDSCFRGNGIKNCGGDIKGDDYEMLRQVLTR
RLTRLRQEPHKLPSLMIIDGGKGHLGVVKEVMDKFEMNIPFVCMSKGVDRNAGFEQFHVIGKEVFTLDKNLPVMKYLQIL
RDEAHNFAIKNHRLGRSRAIKISRLDDIEGVGETRKKALLHYFGSYKAVCDATIYELAKVNGINKLLAEMIFNVLHRKN
>Mature_638_residues
TLEITGSELIKSKLIDAPERSGVYRMFDVNKQVLYVGKAKNLKKRLTNYIKSNLDNKTLRMIANTCFLEYSITNSEVEAL
LLEAQLIKKFQPKFNILLKDCKSFPFIKLRLDHDFPQLLKYRGKTLSDGKFFGPFASSVEVNTTLTELQKIFKLRSCTDN
YFNSRTRPCLQYEIKRCYAPCVGKINKEDYRDLVTQVKDFLQGRTKELQENLSRKMEELSSQMRFEEAAEIRDRIKALSY
VQLKAGVSDVVKDADIIAIVEKNGHYCVEVFLYRAGQACGNIPYFPTATENSTKEEVLEYFLLQFYQKQHVPAAIIINHE
INDKENVIEAIKKINNILQINITVPNKGGKAKLVQNAETHALFSLEQYLKKFAKNQEIMFEIKELFGLSEIPERIEIYDN
SHIQGKFAVGVMVVAGKVGFDKKEYRVFNVHTPSLVCHSRESGDPKRLMDSCFRGNGIKNCGGDIKGDDYEMLRQVLTRR
LTRLRQEPHKLPSLMIIDGGKGHLGVVKEVMDKFEMNIPFVCMSKGVDRNAGFEQFHVIGKEVFTLDKNLPVMKYLQILR
DEAHNFAIKNHRLGRSRAIKISRLDDIEGVGETRKKALLHYFGSYKAVCDATIYELAKVNGINKLLAEMIFNVLHRKN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=636, Percent_Identity=35.8490566037736, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=30.0518134715026, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 73355; Mature: 73224

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEITGSELIKSKLIDAPERSGVYRMFDVNKQVLYVGKAKNLKKRLTNYIKSNLDNKTL
CEEEECHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHCCCHHHH
RMIANTCFLEYSITNSEVEALLLEAQLIKKFQPKFNILLKDCKSFPFIKLRLDHDFPQLL
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHH
KYRGKTLSDGKFFGPFASSVEVNTTLTELQKIFKLRSCTDNYFNSRTRPCLQYEIKRCYA
HHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
PCVGKINKEDYRDLVTQVKDFLQGRTKELQENLSRKMEELSSQMRFEEAAEIRDRIKALS
HHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVQLKAGVSDVVKDADIIAIVEKNGHYCVEVFLYRAGQACGNIPYFPTATENSTKEEVLE
HHHHHHCHHHHHCCCCEEEEEECCCCEEEHHHHHHHCHHCCCCCCCCCCCCCCCHHHHHH
YFLLQFYQKQHVPAAIIINHEINDKENVIEAIKKINNILQINITVPNKGGKAKLVQNAET
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEEEECCCHH
HALFSLEQYLKKFAKNQEIMFEIKELFGLSEIPERIEIYDNSHIQGKFAVGVMVVAGKVG
HHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHCCHHHEECCCCCCCCCCEEEEEEEECCCC
FDKKEYRVFNVHTPSLVCHSRESGDPKRLMDSCFRGNGIKNCGGDIKGDDYEMLRQVLTR
CCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
RLTRLRQEPHKLPSLMIIDGGKGHLGVVKEVMDKFEMNIPFVCMSKGVDRNAGFEQFHVI
HHHHHHHCHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHH
GKEVFTLDKNLPVMKYLQILRDEAHNFAIKNHRLGRSRAIKISRLDDIEGVGETRKKALL
HHHHHEECCCCCHHHHHHHHHHHHHCEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHH
HYFGSYKAVCDATIYELAKVNGINKLLAEMIFNVLHRKN
HHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLEITGSELIKSKLIDAPERSGVYRMFDVNKQVLYVGKAKNLKKRLTNYIKSNLDNKTL
EEEECHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHCCCHHHH
RMIANTCFLEYSITNSEVEALLLEAQLIKKFQPKFNILLKDCKSFPFIKLRLDHDFPQLL
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHH
KYRGKTLSDGKFFGPFASSVEVNTTLTELQKIFKLRSCTDNYFNSRTRPCLQYEIKRCYA
HHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
PCVGKINKEDYRDLVTQVKDFLQGRTKELQENLSRKMEELSSQMRFEEAAEIRDRIKALS
HHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVQLKAGVSDVVKDADIIAIVEKNGHYCVEVFLYRAGQACGNIPYFPTATENSTKEEVLE
HHHHHHCHHHHHCCCCEEEEEECCCCEEEHHHHHHHCHHCCCCCCCCCCCCCCCHHHHHH
YFLLQFYQKQHVPAAIIINHEINDKENVIEAIKKINNILQINITVPNKGGKAKLVQNAET
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEEEECCCHH
HALFSLEQYLKKFAKNQEIMFEIKELFGLSEIPERIEIYDNSHIQGKFAVGVMVVAGKVG
HHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHCCHHHEECCCCCCCCCCEEEEEEEECCCC
FDKKEYRVFNVHTPSLVCHSRESGDPKRLMDSCFRGNGIKNCGGDIKGDDYEMLRQVLTR
CCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
RLTRLRQEPHKLPSLMIIDGGKGHLGVVKEVMDKFEMNIPFVCMSKGVDRNAGFEQFHVI
HHHHHHHCHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHH
GKEVFTLDKNLPVMKYLQILRDEAHNFAIKNHRLGRSRAIKISRLDDIEGVGETRKKALL
HHHHHEECCCCCHHHHHHHHHHHHHCEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHH
HYFGSYKAVCDATIYELAKVNGINKLLAEMIFNVLHRKN
HHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA