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The map label for this gene is pbpA2 [H]

Identifier: 15892778

GI number: 15892778

Start: 806140

End: 807825

Strand: Reverse

Name: pbpA2 [H]

Synonym: RC0855

Alternate gene names: 15892778

Gene position: 807825-806140 (Counterclockwise)

Preceding gene: 15892779

Following gene: 15892777

Centisome position: 63.67

GC content: 34.34

Gene sequence:

>1686_bases
ATGAAACAAATTTGGGAAAAATGGAAACCTACAATTAAAAGTCTAACAATTTGGAATGTTTGTAGTAAAAATACAAAAAT
CCGATTATTAATGGTTATTTGTGTCTTTTCTTTTCTTTTTTGTACTTTATCTTACAGATTGATAATCGTTGCTACGAGTG
TTTACGATAAAAATATTAATTCCTTTAAAAAAAATCATCAATTTAGAAAAGAAATAGTTGATCGAAACGGTAATTTATTA
GCAGTGAACCTACCTTCTGCCTCATTATTTGCTAATCCACAAATAGTACTTGATCCTGAAACTTCCGTAAAAAAGCTAGC
AGAAATTCTACCTGATATTAATAAAGCTAAATTACTTGCAGAACTTAAGTCAAATAAAAGCTTTATATGGGTAAAAAGGG
ATGTACTACCTAGTCAGCAAGAAAAGATAACTAGCCTTGGGTTACTTGGTTTTGAATTTGAAGAAGAGCAGAAACGAATT
TATACCTTTTCTAATTTATTGTCGCATGTTGTCGGTTATGTAGGCAGAGACTCGGTAGGGCTTAGTGGCTTAGAGCTCGC
TTATGATAAGTATTTAACTAATTCTGATTATGAATTAAACGAACCAAAGAATCGGAAAGAACCGCTTCAATTATCTATTG
ATATCAGATTACAAAGTATTTTAAGTGAGGAGATTGATAAAACTTTAAAGCAATTTAAGGCCATAGGAGCAGTAGGCATT
ATTGCTGATCCAAATAATGGCGAGATTTTAGCATTAGTAAATAAGCCTGATTTCGATCCACATTATCCGAGTTTAGCCAA
ACCGGAAGAGCTGTTTAATATAGCAAGTCTCGGGATTTACGAAATGGGTTCGGTGTTTAAGGCATTAACTATGGCAGTTG
GCTTTGATACCGGTGTAATAAATATGAATGATGCTTATGATATAAGTTATATGAAAGTAGGAGGATTCCAGCTTAAGGAT
TATACGCCAAGGCAAGGATGGCATAGTGTACCTGAGATTTTTCTATATTCTTCAAATATTGGCACAAGTCAAATTATGCT
TGAAATCGGTAAAAGCAATTTTAAAAAATACCTAAAGAAATTAGGTCTATTAGATCAGTTGCAAATAGAATTACCTGAAA
GAGGTACTCCGTTATTTCCTTCCGAGAAAAGATGGAATGAGTTAACGAGTGTTACTATGTCGTATGGCTACGGCATTTCG
ATTAGCCCTTTGCATTTTGTTAGAGCAATGTTACCGGTTGTTAACGGCGGTACTTTATATGATCTTACTTTATTAAAAAG
AAAGGATGAAAAAGTAATAGGTACAAAAGTTTTTAGTGAAAATACCTCTACCCAAATGAAAAAATTATTTAGAGCGGTAG
TAAAAGAAGGTAACGGTAAAAGAGCAGAGGTCAAAGGCTATCTTATCGGCGGTAAGACCGGTACGGCAGAAAAACTTTCA
CAAGGGGCAGGAGGAAAAAAGAAATATCTAAAAAATAGTAGAGCGTCATCGTTTTTAGGTATGCTGCCTGCATCTAACCC
GCAATATATTATTTTTATTAGATTTGATGAGCCGAAACCGACTAAAGAAAGCTTTGGCTTTGCAACCGCAAGTTGGACGG
CTGCTCCTACTGCCGGTAGAGTATTTGAACGTATGATATCTTTATATGGTTTAGAACCGATAGAACAAAGTGAGGAAGAA
AGTTAA

Upstream 100 bases:

>100_bases
ATCAAGTTTTGAAAAGGTTTTAAAGTACTGGATTCCCGCTTTCGCGGGAATGACATAAGGATTGCGGAAATATTAGTGTT
TGAAACACCATAAATAACAT

Downstream 100 bases:

>100_bases
AATATTACCTAATAATTATAGATTTTGTCATTGCGAGCAGGCATTGTTGCGTAGATCGGTAAAACCTACTTGATGTCATC
CCCGCCTATGCGGGAATGAC

Product: penicillin-binding protein

Products: NA

Alternate protein names: Sporulation-specific penicillin-binding protein [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MKQIWEKWKPTIKSLTIWNVCSKNTKIRLLMVICVFSFLFCTLSYRLIIVATSVYDKNINSFKKNHQFRKEIVDRNGNLL
AVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLAELKSNKSFIWVKRDVLPSQQEKITSLGLLGFEFEEEQKRI
YTFSNLLSHVVGYVGRDSVGLSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
IADPNNGEILALVNKPDFDPHYPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGVINMNDAYDISYMKVGGFQLKD
YTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKKLGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGIS
ISPLHFVRAMLPVVNGGTLYDLTLLKRKDEKVIGTKVFSENTSTQMKKLFRAVVKEGNGKRAEVKGYLIGGKTGTAEKLS
QGAGGKKKYLKNSRASSFLGMLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGRVFERMISLYGLEPIEQSEEE
S

Sequences:

>Translated_561_residues
MKQIWEKWKPTIKSLTIWNVCSKNTKIRLLMVICVFSFLFCTLSYRLIIVATSVYDKNINSFKKNHQFRKEIVDRNGNLL
AVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLAELKSNKSFIWVKRDVLPSQQEKITSLGLLGFEFEEEQKRI
YTFSNLLSHVVGYVGRDSVGLSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
IADPNNGEILALVNKPDFDPHYPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGVINMNDAYDISYMKVGGFQLKD
YTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKKLGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGIS
ISPLHFVRAMLPVVNGGTLYDLTLLKRKDEKVIGTKVFSENTSTQMKKLFRAVVKEGNGKRAEVKGYLIGGKTGTAEKLS
QGAGGKKKYLKNSRASSFLGMLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGRVFERMISLYGLEPIEQSEEE
S
>Mature_561_residues
MKQIWEKWKPTIKSLTIWNVCSKNTKIRLLMVICVFSFLFCTLSYRLIIVATSVYDKNINSFKKNHQFRKEIVDRNGNLL
AVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLAELKSNKSFIWVKRDVLPSQQEKITSLGLLGFEFEEEQKRI
YTFSNLLSHVVGYVGRDSVGLSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
IADPNNGEILALVNKPDFDPHYPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGVINMNDAYDISYMKVGGFQLKD
YTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKKLGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGIS
ISPLHFVRAMLPVVNGGTLYDLTLLKRKDEKVIGTKVFSENTSTQMKKLFRAVVKEGNGKRAEVKGYLIGGKTGTAEKLS
QGAGGKKKYLKNSRASSFLGMLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGRVFERMISLYGLEPIEQSEEE
S

Specific function: Penicillin-binding protein with an unknown catalytic activity. May have a specialized role in the morphogenesis of spore cortex, which is a modified form of peptidoglycan. Pore cortex formation is determined primarily by the mother cell [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PASTA domain [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=508, Percent_Identity=28.740157480315, Blast_Score=199, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR011927 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63100; Mature: 63100

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIWEKWKPTIKSLTIWNVCSKNTKIRLLMVICVFSFLFCTLSYRLIIVATSVYDKNIN
CCHHHHHHCHHHHHEEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHHHCCHH
SFKKNHQFRKEIVDRNGNLLAVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLA
HHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHHHH
ELKSNKSFIWVKRDVLPSQQEKITSLGLLGFEFEEEQKRIYTFSNLLSHVVGYVGRDSVG
HHHCCCCEEEEECCCCCCHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
LSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEE
IADPNNGEILALVNKPDFDPHYPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGVI
EECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NMNDAYDISYMKVGGFQLKDYTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKK
ECCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
LGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGISISPLHFVRAMLPVVNGGTLY
CCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCEE
DLTLLKRKDEKVIGTKVFSENTSTQMKKLFRAVVKEGNGKRAEVKGYLIGGKTGTAEKLS
EEEEECCCCCCEEEHEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHH
QGAGGKKKYLKNSRASSFLGMLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGR
CCCCCHHHHHHCCCHHHHHCCCCCCCCCEEEEEEECCCCCCHHHCCCEEECCCCCCCHHH
VFERMISLYGLEPIEQSEEES
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKQIWEKWKPTIKSLTIWNVCSKNTKIRLLMVICVFSFLFCTLSYRLIIVATSVYDKNIN
CCHHHHHHCHHHHHEEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHHHCCHH
SFKKNHQFRKEIVDRNGNLLAVNLPSASLFANPQIVLDPETSVKKLAEILPDINKAKLLA
HHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHHHH
ELKSNKSFIWVKRDVLPSQQEKITSLGLLGFEFEEEQKRIYTFSNLLSHVVGYVGRDSVG
HHHCCCCEEEEECCCCCCHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
LSGLELAYDKYLTNSDYELNEPKNRKEPLQLSIDIRLQSILSEEIDKTLKQFKAIGAVGI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEE
IADPNNGEILALVNKPDFDPHYPSLAKPEELFNIASLGIYEMGSVFKALTMAVGFDTGVI
EECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NMNDAYDISYMKVGGFQLKDYTPRQGWHSVPEIFLYSSNIGTSQIMLEIGKSNFKKYLKK
ECCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
LGLLDQLQIELPERGTPLFPSEKRWNELTSVTMSYGYGISISPLHFVRAMLPVVNGGTLY
CCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCEE
DLTLLKRKDEKVIGTKVFSENTSTQMKKLFRAVVKEGNGKRAEVKGYLIGGKTGTAEKLS
EEEEECCCCCCEEEHEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHH
QGAGGKKKYLKNSRASSFLGMLPASNPQYIIFIRFDEPKPTKESFGFATASWTAAPTAGR
CCCCCHHHHHHCCCHHHHHCCCCCCCCCEEEEEEECCCCCCHHHCCCEEECCCCCCCHHH
VFERMISLYGLEPIEQSEEES
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8289242; 9384377; 8244929; 8436954 [H]