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The map label for this gene is mdtB [H]

Identifier: 15892491

GI number: 15892491

Start: 559429

End: 559938

Strand: Reverse

Name: mdtB [H]

Synonym: RC0568

Alternate gene names: 15892491

Gene position: 559938-559429 (Counterclockwise)

Preceding gene: 15892492

Following gene: 15892490

Centisome position: 44.13

GC content: 37.45

Gene sequence:

>510_bases
GTGGACTATTACGCTGAAACAATTATGGCTGAGCGTTTATCTATGCTGCCGGGTGTTGCACAGATACAAGTTTACGGCTC
ACAGCAATATGCAGTGCGTGTGCAGATTGACCCTGTTAAAATGGCAGTAAATAATATAGGGCTTGACCAAGTATCAAACA
TTATCAGCTCTGCTAACGTTAATTTACCGACCGGAGCTTTATACGGTACAGATATCTACTCAAGTATTAGAGCCCCTGGG
CAATTACAAAATGTTAAAGAATATAATGAGTTAATATTAACTTATAAAAACGGTAATCCGCTTTTTCTTAAAAATATTGG
GAAAACCATTGATAGCGTAGCTAATAATAAAATAGCCGCTTGGTATAGGGATAAGCCGGGGGTAATACTTGCTATTCAAA
AACAACCGGATACTACTAATACTATTGAAATAGTCGACTCTATAAAAGAAGTATTGCCGTTGCTTCGCAGGCAAATCCCT
GAGGGCATTAATATTAATATCATGTTTTGA

Upstream 100 bases:

>100_bases
AACGACTTACCTACCCCGCCCTCATATTGTAAAGTAAATCCTGCCGACGCACCTATATTTTATTTATCTTTAACCTCTGA
GACTCTTCCCCTTATATACC

Downstream 100 bases:

>100_bases
TAGGTCAATTTCTATATCAGAGAATCGGTAAATGATACCAATTTTACTATGCTACTCGCTTTAATACTCGTAGTGATTGC
TATATTTCTCTTTCTACATA

Product: RND efflux transporter

Products: NA

Alternate protein names: Multidrug transporter MdtB [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MDYYAETIMAERLSMLPGVAQIQVYGSQQYAVRVQIDPVKMAVNNIGLDQVSNIISSANVNLPTGALYGTDIYSSIRAPG
QLQNVKEYNELILTYKNGNPLFLKNIGKTIDSVANNKIAAWYRDKPGVILAIQKQPDTTNTIEIVDSIKEVLPLLRRQIP
EGININIMF

Sequences:

>Translated_169_residues
MDYYAETIMAERLSMLPGVAQIQVYGSQQYAVRVQIDPVKMAVNNIGLDQVSNIISSANVNLPTGALYGTDIYSSIRAPG
QLQNVKEYNELILTYKNGNPLFLKNIGKTIDSVANNKIAAWYRDKPGVILAIQKQPDTTNTIEIVDSIKEVLPLLRRQIP
EGININIMF
>Mature_169_residues
MDYYAETIMAERLSMLPGVAQIQVYGSQQYAVRVQIDPVKMAVNNIGLDQVSNIISSANVNLPTGALYGTDIYSSIRAPG
QLQNVKEYNELILTYKNGNPLFLKNIGKTIDSVANNKIAAWYRDKPGVILAIQKQPDTTNTIEIVDSIKEVLPLLRRQIP
EGININIMF

Specific function: Could Be A Drug Efflux Pump (By Similarity). [C]

COG id: COG0841

COG function: function code V; Cation/multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1788390, Length=163, Percent_Identity=30.0613496932515, Blast_Score=96, Evalue=8e-22,
Organism=Escherichia coli, GI1788391, Length=164, Percent_Identity=35.3658536585366, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036
- InterPro:   IPR022831 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 18799; Mature: 18799

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYYAETIMAERLSMLPGVAQIQVYGSQQYAVRVQIDPVKMAVNNIGLDQVSNIISSANV
CCHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEECHHHHHHHHCCHHHHHHHHHHCCC
NLPTGALYGTDIYSSIRAPGQLQNVKEYNELILTYKNGNPLFLKNIGKTIDSVANNKIAA
CCCCCCEECCHHHHHHCCCCHHHHHHHHCEEEEEEECCCEEEHHHHHHHHHHHCCCCEEE
WYRDKPGVILAIQKQPDTTNTIEIVDSIKEVLPLLRRQIPEGININIMF
EEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MDYYAETIMAERLSMLPGVAQIQVYGSQQYAVRVQIDPVKMAVNNIGLDQVSNIISSANV
CCHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEECHHHHHHHHCCHHHHHHHHHHCCC
NLPTGALYGTDIYSSIRAPGQLQNVKEYNELILTYKNGNPLFLKNIGKTIDSVANNKIAA
CCCCCCEECCHHHHHHCCCCHHHHHHHHCEEEEEEECCCEEEHHHHHHHHHHHCCCCEEE
WYRDKPGVILAIQKQPDTTNTIEIVDSIKEVLPLLRRQIPEGININIMF
EEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]