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The map label for this gene is coxA [H]

Identifier: 15892476

GI number: 15892476

Start: 544803

End: 546401

Strand: Reverse

Name: coxA [H]

Synonym: RC0553

Alternate gene names: 15892476

Gene position: 546401-544803 (Counterclockwise)

Preceding gene: 15892477

Following gene: 15892475

Centisome position: 43.07

GC content: 41.28

Gene sequence:

>1599_bases
ATGGATATAACTACTACCGAAATTTATCACGATGGCCACCACACCCCACACGGTTGGAGGCGATGGCTTTTTTCTACCAA
TCACAAAGATATCGGCATTATGTATATCATATTTGCCGTTTTTGCCGGAATTGTCGGAGGTTTGTTTTCACTGCTTTTTA
GGTTAGAGCTTGCAATGCCCGGCGGCACTTTCTTAAATCATGATTTCCAGCTATATAACGTGCTTATCACAGCACATGCG
GTTATTATGGTATTCTTTATGATTATGCCGGCTTTGTTCGGTGGCTTTGGTAACTATTTCGTACCTCTGTTAATAGGGGC
TCCCGATATGGCATTTCCACGCCTTAACAATATCAGTTTTTGGCTACTAGTGCCTGCTTTTCTTTTACTTATGGGATCAG
CTTTTGTTGACGGTGGGCCAGGAACGGGCTGGACGCTCTACCCTCCTTTAAGTAATTTAAGCGGTCACCCCGGTGCAGCC
GTTGATATGGCCATTTTCAGTTTACATTTAACCGGTCTATCGTCAATCCTTGGATCAATTAACTTAATCGTTACTATCTT
TAATATGAGAGCTCCGGGAATGGGCCTTTTCAAGATGCCGTTATTCGTTTGGTCTATTTTAGTTACCGCATTTCTAATAA
TTCTTGCGATGCCGGTACTTGGTGGAGCTATTACTATGCTACTTACAGATCGTAATTTTGGAACTACTTTCTTTAAGCCT
GACGGCGGCGGTGATCCTGTATTATTTCAGCATCTATTTTGGTTTTTCGGTCATCCTGAAGTATATATCGTAATACTTCC
AGGCTTTGGTATAGTAAGTCAAGTTATTTCAACTTTTTCACGCAAACCTATATTCGGCTATCAAGGTATGATCGGGGCTA
TGGTGATCATAGGCTTTGTTGGATTTATCGTATGGGCTCACCATATGTTTACTGTTGGGCTTTCTTATAATGCACTTATA
TATTTCACTGCCGGAACGATGATTATAGCAGTTCCTACGGGTATTAAAATATTTAGCTGGATAGCGACTATGTGGGGTGG
TTCGATTACATTCCCAACTCCTATGCTATTTTCGATAGGATTTATTATATTATTCACGATCGGCGGCGTAACCGGCATAA
TCCTATCAAATTCGGCACTTGACAGAGTTCTGCACGATACATATTATGTTGTTGCACATTTCCATTATACGATGTCGCTC
GGTGCTTTATTTACGGCATTTGCAGGCTTTTATTATTGGTTTGGCAAAATATCTGGTAAACAATATCCGGACATTTTAGG
CAAAATTCATTTTTGGATTACCTTTATAGGCGTTAATTTAACTTTCTTCCCGCAGCATTTCTTAGGTCTTGCGGGCATGC
CAAGAAGAATACCGGACTACCCTGAAGCTTTCGCCGGCTGGAATATGGTTTCGTCGATAGGAGCAGGTATTTCTATGTTT
GCTGCCCTTTATTTTGTATTTATCGTTTTCTATACGCTAAAATACGGCAAAGATTGTCCAAACAATCCTTGGGGAGAAGG
AGCAGACACATTAGAGTGGACACTTACCTCACCACCACCGTTCCATACTTTTGAAACACCACCGCATATTGAGGGGTAA

Upstream 100 bases:

>100_bases
AAATTCAATGGTGGGATTGGGATTATGATAAAATCACTCGGAATATTCCGGCAATTGTTGAAACAGATATCGAACAATTA
AAACAGGCAGAATAACAATT

Downstream 100 bases:

>100_bases
TAGTGGCTTTGCTGCGTGGATGCCAAGTCATCATCATTGCGAGGAGTTGCGTTAGCAACGACGCGGCAATCTCATAAGAT
AATATAAAAAAACTCCTGAG

Product: cytochrome c oxidase polypeptide I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MDITTTEIYHDGHHTPHGWRRWLFSTNHKDIGIMYIIFAVFAGIVGGLFSLLFRLELAMPGGTFLNHDFQLYNVLITAHA
VIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISFWLLVPAFLLLMGSAFVDGGPGTGWTLYPPLSNLSGHPGAA
VDMAIFSLHLTGLSSILGSINLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKP
DGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMIGAMVIIGFVGFIVWAHHMFTVGLSYNALI
YFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFSIGFIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSL
GALFTAFAGFYYWFGKISGKQYPDILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMF
AALYFVFIVFYTLKYGKDCPNNPWGEGADTLEWTLTSPPPFHTFETPPHIEG

Sequences:

>Translated_532_residues
MDITTTEIYHDGHHTPHGWRRWLFSTNHKDIGIMYIIFAVFAGIVGGLFSLLFRLELAMPGGTFLNHDFQLYNVLITAHA
VIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISFWLLVPAFLLLMGSAFVDGGPGTGWTLYPPLSNLSGHPGAA
VDMAIFSLHLTGLSSILGSINLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKP
DGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMIGAMVIIGFVGFIVWAHHMFTVGLSYNALI
YFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFSIGFIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSL
GALFTAFAGFYYWFGKISGKQYPDILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMF
AALYFVFIVFYTLKYGKDCPNNPWGEGADTLEWTLTSPPPFHTFETPPHIEG
>Mature_532_residues
MDITTTEIYHDGHHTPHGWRRWLFSTNHKDIGIMYIIFAVFAGIVGGLFSLLFRLELAMPGGTFLNHDFQLYNVLITAHA
VIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISFWLLVPAFLLLMGSAFVDGGPGTGWTLYPPLSNLSGHPGAA
VDMAIFSLHLTGLSSILGSINLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKP
DGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMIGAMVIIGFVGFIVWAHHMFTVGLSYNALI
YFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFSIGFIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSL
GALFTAFAGFYYWFGKISGKQYPDILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMF
AALYFVFIVFYTLKYGKDCPNNPWGEGADTLEWTLTSPPPFHTFETPPHIEG

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=512, Percent_Identity=58.3984375, Blast_Score=579, Evalue=1e-165,
Organism=Escherichia coli, GI1786634, Length=521, Percent_Identity=42.4184261036468, Blast_Score=391, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6226519, Length=528, Percent_Identity=55.6818181818182, Blast_Score=601, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=60.2484472049689, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=55.4655870445344, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6226521, Length=114, Percent_Identity=36.8421052631579, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6226522, Length=79, Percent_Identity=48.1012658227848, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6226520, Length=54, Percent_Identity=50, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 58878; Mature: 58878

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITTTEIYHDGHHTPHGWRRWLFSTNHKDIGIMYIIFAVFAGIVGGLFSLLFRLELAMP
CCCCEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGTFLNHDFQLYNVLITAHAVIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISF
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCCCCCCHH
WLLVPAFLLLMGSAFVDGGPGTGWTLYPPLSNLSGHPGAAVDMAIFSLHLTGLSSILGSI
HHHHHHHHHHHCCHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKP
HHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEECC
DGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMIGAMVIIGFV
CCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
GFIVWAHHMFTVGLSYNALIYFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFSIG
HHHHHHHHHHHCCCCCCEEEEEEECEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHH
FIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSLGALFTAFAGFYYWFGKISGK
HHHHHHHHHHHEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QYPDILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMF
CCHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
AALYFVFIVFYTLKYGKDCPNNPWGEGADTLEWTLTSPPPFHTFETPPHIEG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDITTTEIYHDGHHTPHGWRRWLFSTNHKDIGIMYIIFAVFAGIVGGLFSLLFRLELAMP
CCCCEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGTFLNHDFQLYNVLITAHAVIMVFFMIMPALFGGFGNYFVPLLIGAPDMAFPRLNNISF
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCCCCCCHH
WLLVPAFLLLMGSAFVDGGPGTGWTLYPPLSNLSGHPGAAVDMAIFSLHLTGLSSILGSI
HHHHHHHHHHHCCHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NLIVTIFNMRAPGMGLFKMPLFVWSILVTAFLIILAMPVLGGAITMLLTDRNFGTTFFKP
HHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEECC
DGGGDPVLFQHLFWFFGHPEVYIVILPGFGIVSQVISTFSRKPIFGYQGMIGAMVIIGFV
CCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
GFIVWAHHMFTVGLSYNALIYFTAGTMIIAVPTGIKIFSWIATMWGGSITFPTPMLFSIG
HHHHHHHHHHHCCCCCCEEEEEEECEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHH
FIILFTIGGVTGIILSNSALDRVLHDTYYVVAHFHYTMSLGALFTAFAGFYYWFGKISGK
HHHHHHHHHHHEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QYPDILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPEAFAGWNMVSSIGAGISMF
CCHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
AALYFVFIVFYTLKYGKDCPNNPWGEGADTLEWTLTSPPPFHTFETPPHIEG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]