Click here to switch to the map view.

The map label for this gene is tdpX1 [H]

Identifier: 15892374

GI number: 15892374

Start: 446464

End: 447072

Strand: Reverse

Name: tdpX1 [H]

Synonym: RC0451

Alternate gene names: 15892374

Gene position: 447072-446464 (Counterclockwise)

Preceding gene: 15892375

Following gene: 15892373

Centisome position: 35.24

GC content: 35.3

Gene sequence:

>609_bases
ATGAATATGTCAGTATTTGTCGGCAAAACTGCTCCCGATTTTACAGCTAAAGCTATTATGCCTAATAATAATATAGACGA
TAAGTTTAAACTTAGCAATTATGCTGCAGGGGATAATATAGTATTATTTTTTTATCCCCTAGATTTTACTTTTGTTTGTC
CATCGGAAATTATAGCATTTCACAATAAGCTTGGTGAATTTACCGAAAGACGTACTAAAGTAGTAGCTGTTAGTGTTGAT
TCTCATTTTAGCCATTTAGCTTGGAAAAATACTCCGCATAATAAAGGCGGGCTTGGACAAGTACAATTCCCAATGGTTTC
CGATATAAAAAAGGATATTTCTTCAAAATATAATGTACTTAATGAAGACGGTGTTGCTTTGCGTGGAACTTTTTTAATCG
ATAAGGATTTCATAGTACGTCACATGCTAGTTAACGACTTACCTATCGGTCGTGATATTAATTATACATTAAAAGTAATC
GATGCTTTAACTCATCATCAAAAGCACGGCGAAGTTTGTCCTGCCGGCTGGCATAAAGGTGAGGAAGCAATTACCCCATC
ACATGAAGGTATAGCACATTATTTAAGCTCACATGCAGAGAAGCTGTAA

Upstream 100 bases:

>100_bases
TTCGGGAACGAAAATAGATAAGTAGCAATTTATAACGATTTATTATTGTAATAATAATTAGTTTTATATATCATATCAGA
TTATTAATTAATAAAAGGTT

Downstream 100 bases:

>100_bases
TATATTACACTGTGTTATTAAAGTGGAAAACTGTCCTACCGTGGCTTGTCTAGTGTTGTTGCATGGTTCGATGTCATATC
CCGCGAAAGCGGGAATCCAG

Product: thioredoxin peroxidase 1

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNMSVFVGKTAPDFTAKAIMPNNNIDDKFKLSNYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVD
SHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDGVALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVI
DALTHHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL

Sequences:

>Translated_202_residues
MNMSVFVGKTAPDFTAKAIMPNNNIDDKFKLSNYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVD
SHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDGVALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVI
DALTHHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL
>Mature_202_residues
MNMSVFVGKTAPDFTAKAIMPNNNIDDKFKLSNYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVD
SHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDGVALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVI
DALTHHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=193, Percent_Identity=48.7046632124352, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI32455266, Length=193, Percent_Identity=48.7046632124352, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI32455264, Length=193, Percent_Identity=48.7046632124352, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=47.1502590673575, Blast_Score=194, Evalue=3e-50,
Organism=Homo sapiens, GI5453549, Length=193, Percent_Identity=49.2227979274611, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI5802974, Length=193, Percent_Identity=48.1865284974093, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI32483377, Length=189, Percent_Identity=48.6772486772487, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=54.8780487804878, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1786822, Length=149, Percent_Identity=36.9127516778523, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=47.4226804123711, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=47.4226804123711, Blast_Score=188, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17554494, Length=181, Percent_Identity=48.0662983425414, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25153706, Length=189, Percent_Identity=24.8677248677249, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=196, Percent_Identity=40.3061224489796, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=194, Percent_Identity=38.659793814433, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=189, Percent_Identity=28.042328042328, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24656348, Length=193, Percent_Identity=46.6321243523316, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17864676, Length=193, Percent_Identity=46.6321243523316, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17738015, Length=199, Percent_Identity=46.2311557788945, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17157991, Length=192, Percent_Identity=42.1875, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641739, Length=192, Percent_Identity=42.1875, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=37.3684210526316, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24581278, Length=181, Percent_Identity=28.1767955801105, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24652436, Length=194, Percent_Identity=30.4123711340206, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17975518, Length=190, Percent_Identity=29.4736842105263, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652434, Length=190, Percent_Identity=29.4736842105263, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22635; Mature: 22635

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSVFVGKTAPDFTAKAIMPNNNIDDKFKLSNYAAGDNIVLFFYPLDFTFVCPSEIIAF
CCCEEEEECCCCCCEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCEEEECHHHHHHH
HNKLGEFTERRTKVVAVSVDSHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVL
HHHHHHHHHHCEEEEEEEECCCHHHHEECCCCCCCCCCCEEECHHHHHHHHHHHHHHCCC
NEDGVALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDALTHHQKHGEVCPAGWHKG
CCCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
EEAITPSHEGIAHYLSSHAEKL
CCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNMSVFVGKTAPDFTAKAIMPNNNIDDKFKLSNYAAGDNIVLFFYPLDFTFVCPSEIIAF
CCCEEEEECCCCCCEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCEEEECHHHHHHH
HNKLGEFTERRTKVVAVSVDSHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVL
HHHHHHHHHHCEEEEEEEECCCHHHHEECCCCCCCCCCCEEECHHHHHHHHHHHHHHCCC
NEDGVALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDALTHHQKHGEVCPAGWHKG
CCCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
EEAITPSHEGIAHYLSSHAEKL
CCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]