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The map label for this gene is pbpC [H]

Identifier: 15892172

GI number: 15892172

Start: 255730

End: 258120

Strand: Reverse

Name: pbpC [H]

Synonym: RC0249

Alternate gene names: 15892172

Gene position: 258120-255730 (Counterclockwise)

Preceding gene: 15892181

Following gene: 15892171

Centisome position: 20.34

GC content: 33.88

Gene sequence:

>2391_bases
TTGTCTCTCAAAACCAAATTACTTTTTATTACACTCAGCAGCATTATAATATTATATTTTGCTATTCCTCCTGCACCTTT
ACTTAAAGACGTAAGTTTCTCACAAAGAGTATTTGACCGAAACGGCGAGTTAATGCGTATTTCGCTTTCTAAAGACGATA
AATATAGGATATTCACTCCTATACGTGAAATACCGGCCAGTTTTATAGAAACAGTACTACTATATGAAGACAAGCATTTT
TATGCGCATTTTGGCGTTAACCCTGTTTCTTTAGCCAAAGCTTTTTATTCTACTTATTTACAGAATAATCGTAAAATAGG
CGGCTCTACTATAACAATGCAAGTAGCACGTTTAAGATATGGAATAAACTCTTCTACTATTCTTGGTAAAATACATCAAA
TCATTAAAGCTATTCATGTAGAGCTACATTATTCAAAAGATGAAATCCTAGAAGCTTATCTAAATCTAGTGCCTTACGGT
AGTAATATTGAAGGGATAGCAGCCGGCAGTTATATTTACTTCAATCGTGACCTAAAAGATTTAAATTTGATCGATATTCT
AAGCCTTGCAGTAATCCCACAAAATCCACTTAAAAGAGGCGGGAATGATATTAATATTTTTAAAGCACGTAAATATCTAT
TTACCGAGTGGCTCACGATTCACCCACAAGATATTATTTATAATAAGTTAATTAGTTTGCCGGTTAAATTTAATCAAAAT
AAAAAGCTTCCTTTTATTGCACCGCATTTTACTTTAGACATACTAGCAAATAATGATAGCCCTATTATACACACTACTAT
AGATAAAAATCTGCAAGCTGCTATAGAACAACAAGTTCGGCTATATATTAATGATCGGAAAAAATATGGCATTAATAATG
CCTCCGTAATTCTTATTGATTTTACTACTATGGAAGTGCTTGCAAGTATTGGCTCCGGAGAGTTTTTTAATAACGATATT
TGTGGACAGATTAACGGCACTAAAAGCCATAGATCTCCAGGCTCAGCTTTAAAACCGTTTGTCTATGCACTTAGTTTTGA
TCAATCACTAATACATCCGTTAACTTTACTAAAGGATACACCTACTTACTATGATTATTATAAACCGGAAAATTTTGATA
GTAGGTTTGCAGGCGGTTTAAGTGCTAGAGAATCGTTAATAAAGAGCCGTAACATACCTGTAATATTTCTAGCGTCTAAG
TTAAAAAACCCGAATTTTTATGAGTTCTTACAACAAGCAAAAATTAGCGGCTTACGAAAACCTGAAAATTACGGTTTATC
TATAGTGCTCGGCACAGCAGAAATTACTCTTGAAGAGTTAACTACTCTTTATGCTATGCTTGCTAATTTCGGTACTTATA
AACCGCTTAGAAAAGTATTGGATTCTACTATGTCATTCCTGCGAAAGCAGGAATCCATAAAAAATTACCTAAATGTTGGA
ACAAAAATTTCATATGATTTACTGGATTCCCGCTTTCGCGGGAATGACACAGGAGAGGACAAGGATGACACAGACATCGT
ACTACTATCCCCCGAGGCAAGCTATTTAACACTTGATATTATAAAAGATACGACTCGTCCTATTACCTATAATAATACAA
GGCATAACTTACCGATTTATTGGAAAACAGGTACTTCCAGCTCATTTAGAGATGCACTTAGCGTTGGCATATTCGGGAAA
TACGTACTTGCTGTTTGGGTTGGGGATTTCAAAGGGCAAACTCACGGAACATTTACGGGTAATATTGCTGCAGCCCCTTT
ATTCTTTAATATTATCGAAGCCATAGCTAGACCAAATAAAGATGAGGATTTAATCCTTTCAAAAATTAATGCACTAAATA
TTACTAAAGTAAAAGTTTGTGCAGATACGGGAGATATCGATAACGATATGTGTCCGGTTAAAGCAGAAACCTTATTCATT
CAAGGCAAATCACCGATAAAACAATCCGGTATTTATAGAAAAATGTTGATAGATTTAAAAACCGGTATGCCTACTTGTAA
CTTTATTAAAGGACAAACAGAATATAAAACAGTAAATTTATGGCCAACAGATATGCTTGCGGTTTATCAAAAAGCAGGAA
TACATATATTACCGAAACCGATACCTACAAACCATTGCAATAGGTTGATAAATTGGCATCATCAAAAACCTAAAATTATA
TACCCGTTAAAAAATTCCGTACATTCAATTAAAAATAGTGATAACATTACTTTTAGTGCGATTAGCGATAATAAAACCAA
CAACATTTTTTGGTTTGTGGAAAATGAATTAATAGCAACCGCGAAACCAAACGAAGCAGTAATATGGAAAGCAAAAGCCG
GTGAATTTATTATTAGAGCTATCAGCGATAGCGGCGAAAGCGACAGTATAAAAATTTATATTAAAGAATAG

Upstream 100 bases:

>100_bases
GAAACTTGCAGTTTTTCCTCGCAATGACGCAAAAATCGTTCCACGCAACCGCGCTTTCTTACCTACACGGGAATGACATT
AAACTATAAGGTATATTACT

Downstream 100 bases:

>100_bases
ATTAGCGGTTATATATGAAATTTAAAATTCCCACAGAAATTGAGATTAAACCTTTCACAGAAGAAGAAACTGCTCTTGAT
GCTTTAAAAGCAAATATTCT

Product: bifunctional penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 796; Mature: 795

Protein sequence:

>796_residues
MSLKTKLLFITLSSIIILYFAIPPAPLLKDVSFSQRVFDRNGELMRISLSKDDKYRIFTPIREIPASFIETVLLYEDKHF
YAHFGVNPVSLAKAFYSTYLQNNRKIGGSTITMQVARLRYGINSSTILGKIHQIIKAIHVELHYSKDEILEAYLNLVPYG
SNIEGIAAGSYIYFNRDLKDLNLIDILSLAVIPQNPLKRGGNDINIFKARKYLFTEWLTIHPQDIIYNKLISLPVKFNQN
KKLPFIAPHFTLDILANNDSPIIHTTIDKNLQAAIEQQVRLYINDRKKYGINNASVILIDFTTMEVLASIGSGEFFNNDI
CGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDTPTYYDYYKPENFDSRFAGGLSARESLIKSRNIPVIFLASK
LKNPNFYEFLQQAKISGLRKPENYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKVLDSTMSFLRKQESIKNYLNVG
TKISYDLLDSRFRGNDTGEDKDDTDIVLLSPEASYLTLDIIKDTTRPITYNNTRHNLPIYWKTGTSSSFRDALSVGIFGK
YVLAVWVGDFKGQTHGTFTGNIAAAPLFFNIIEAIARPNKDEDLILSKINALNITKVKVCADTGDIDNDMCPVKAETLFI
QGKSPIKQSGIYRKMLIDLKTGMPTCNFIKGQTEYKTVNLWPTDMLAVYQKAGIHILPKPIPTNHCNRLINWHHQKPKII
YPLKNSVHSIKNSDNITFSAISDNKTNNIFWFVENELIATAKPNEAVIWKAKAGEFIIRAISDSGESDSIKIYIKE

Sequences:

>Translated_796_residues
MSLKTKLLFITLSSIIILYFAIPPAPLLKDVSFSQRVFDRNGELMRISLSKDDKYRIFTPIREIPASFIETVLLYEDKHF
YAHFGVNPVSLAKAFYSTYLQNNRKIGGSTITMQVARLRYGINSSTILGKIHQIIKAIHVELHYSKDEILEAYLNLVPYG
SNIEGIAAGSYIYFNRDLKDLNLIDILSLAVIPQNPLKRGGNDINIFKARKYLFTEWLTIHPQDIIYNKLISLPVKFNQN
KKLPFIAPHFTLDILANNDSPIIHTTIDKNLQAAIEQQVRLYINDRKKYGINNASVILIDFTTMEVLASIGSGEFFNNDI
CGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDTPTYYDYYKPENFDSRFAGGLSARESLIKSRNIPVIFLASK
LKNPNFYEFLQQAKISGLRKPENYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKVLDSTMSFLRKQESIKNYLNVG
TKISYDLLDSRFRGNDTGEDKDDTDIVLLSPEASYLTLDIIKDTTRPITYNNTRHNLPIYWKTGTSSSFRDALSVGIFGK
YVLAVWVGDFKGQTHGTFTGNIAAAPLFFNIIEAIARPNKDEDLILSKINALNITKVKVCADTGDIDNDMCPVKAETLFI
QGKSPIKQSGIYRKMLIDLKTGMPTCNFIKGQTEYKTVNLWPTDMLAVYQKAGIHILPKPIPTNHCNRLINWHHQKPKII
YPLKNSVHSIKNSDNITFSAISDNKTNNIFWFVENELIATAKPNEAVIWKAKAGEFIIRAISDSGESDSIKIYIKE
>Mature_795_residues
SLKTKLLFITLSSIIILYFAIPPAPLLKDVSFSQRVFDRNGELMRISLSKDDKYRIFTPIREIPASFIETVLLYEDKHFY
AHFGVNPVSLAKAFYSTYLQNNRKIGGSTITMQVARLRYGINSSTILGKIHQIIKAIHVELHYSKDEILEAYLNLVPYGS
NIEGIAAGSYIYFNRDLKDLNLIDILSLAVIPQNPLKRGGNDINIFKARKYLFTEWLTIHPQDIIYNKLISLPVKFNQNK
KLPFIAPHFTLDILANNDSPIIHTTIDKNLQAAIEQQVRLYINDRKKYGINNASVILIDFTTMEVLASIGSGEFFNNDIC
GQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDTPTYYDYYKPENFDSRFAGGLSARESLIKSRNIPVIFLASKL
KNPNFYEFLQQAKISGLRKPENYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKVLDSTMSFLRKQESIKNYLNVGT
KISYDLLDSRFRGNDTGEDKDDTDIVLLSPEASYLTLDIIKDTTRPITYNNTRHNLPIYWKTGTSSSFRDALSVGIFGKY
VLAVWVGDFKGQTHGTFTGNIAAAPLFFNIIEAIARPNKDEDLILSKINALNITKVKVCADTGDIDNDMCPVKAETLFIQ
GKSPIKQSGIYRKMLIDLKTGMPTCNFIKGQTEYKTVNLWPTDMLAVYQKAGIHILPKPIPTNHCNRLINWHHQKPKIIY
PLKNSVHSIKNSDNITFSAISDNKTNNIFWFVENELIATAKPNEAVIWKAKAGEFIIRAISDSGESDSIKIYIKE

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=839, Percent_Identity=25.2681764004768, Blast_Score=254, Evalue=2e-68,
Organism=Escherichia coli, GI1786343, Length=557, Percent_Identity=23.1597845601436, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87082258, Length=305, Percent_Identity=28.1967213114754, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 90023; Mature: 89892

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKTKLLFITLSSIIILYFAIPPAPLLKDVSFSQRVFDRNGELMRISLSKDDKYRIFTP
CCCCCEEHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHCCCCCEEEEEECCCCCEEEECC
IREIPASFIETVLLYEDKHFYAHFGVNPVSLAKAFYSTYLQNNRKIGGSTITMQVARLRY
HHHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHC
GINSSTILGKIHQIIKAIHVELHYSKDEILEAYLNLVPYGSNIEGIAAGSYIYFNRDLKD
CCCCHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHCCCCCCCCCEEECEEEEEECCCCC
LNLIDILSLAVIPQNPLKRGGNDINIFKARKYLFTEWLTIHPQDIIYNKLISLPVKFNQN
CCHHHHHHHHCCCCCHHHCCCCEEEEEEHHHHHHHHHEEECCHHHHHHHHHHCCEEECCC
KKLPFIAPHFTLDILANNDSPIIHTTIDKNLQAAIEQQVRLYINDRKKYGINNASVILID
CCCCEEECCEEEEEEECCCCCEEEEECCHHHHHHHHHHHEEEEECCHHCCCCCCEEEEEE
FTTMEVLASIGSGEFFNNDICGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDT
EHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCC
PTYYDYYKPENFDSRFAGGLSARESLIKSRNIPVIFLASKLKNPNFYEFLQQAKISGLRK
CCCCCCCCCCCCCCHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
PENYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKVLDSTMSFLRKQESIKNYLNVG
CCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TKISYDLLDSRFRGNDTGEDKDDTDIVLLSPEASYLTLDIIKDTTRPITYNNTRHNLPIY
CEEEHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCEEECCCCCCCEEE
WKTGTSSSFRDALSVGIFGKYVLAVWVGDFKGQTHGTFTGNIAAAPLFFNIIEAIARPNK
EECCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHCCCC
DEDLILSKINALNITKVKVCADTGDIDNDMCPVKAETLFIQGKSPIKQSGIYRKMLIDLK
CHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCHHHCCCHHHHHEEHH
TGMPTCNFIKGQTEYKTVNLWPTDMLAVYQKAGIHILPKPIPTNHCNRLINWHHQKPKII
CCCCCCCEECCCCCEEEEEECCHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCEE
YPLKNSVHSIKNSDNITFSAISDNKTNNIFWFVENELIATAKPNEAVIWKAKAGEFIIRA
ECCHHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCEEEEEECCCCEEEEE
ISDSGESDSIKIYIKE
ECCCCCCCEEEEEEEC
>Mature Secondary Structure 
SLKTKLLFITLSSIIILYFAIPPAPLLKDVSFSQRVFDRNGELMRISLSKDDKYRIFTP
CCCCEEHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHCCCCCEEEEEECCCCCEEEECC
IREIPASFIETVLLYEDKHFYAHFGVNPVSLAKAFYSTYLQNNRKIGGSTITMQVARLRY
HHHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHC
GINSSTILGKIHQIIKAIHVELHYSKDEILEAYLNLVPYGSNIEGIAAGSYIYFNRDLKD
CCCCHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHCCCCCCCCCEEECEEEEEECCCCC
LNLIDILSLAVIPQNPLKRGGNDINIFKARKYLFTEWLTIHPQDIIYNKLISLPVKFNQN
CCHHHHHHHHCCCCCHHHCCCCEEEEEEHHHHHHHHHEEECCHHHHHHHHHHCCEEECCC
KKLPFIAPHFTLDILANNDSPIIHTTIDKNLQAAIEQQVRLYINDRKKYGINNASVILID
CCCCEEECCEEEEEEECCCCCEEEEECCHHHHHHHHHHHEEEEECCHHCCCCCCEEEEEE
FTTMEVLASIGSGEFFNNDICGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDT
EHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCC
PTYYDYYKPENFDSRFAGGLSARESLIKSRNIPVIFLASKLKNPNFYEFLQQAKISGLRK
CCCCCCCCCCCCCCHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
PENYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKVLDSTMSFLRKQESIKNYLNVG
CCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TKISYDLLDSRFRGNDTGEDKDDTDIVLLSPEASYLTLDIIKDTTRPITYNNTRHNLPIY
CEEEHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCEEECCCCCCCEEE
WKTGTSSSFRDALSVGIFGKYVLAVWVGDFKGQTHGTFTGNIAAAPLFFNIIEAIARPNK
EECCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHCCCC
DEDLILSKINALNITKVKVCADTGDIDNDMCPVKAETLFIQGKSPIKQSGIYRKMLIDLK
CHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCHHHCCCHHHHHEEHH
TGMPTCNFIKGQTEYKTVNLWPTDMLAVYQKAGIHILPKPIPTNHCNRLINWHHQKPKII
CCCCCCCEECCCCCEEEEEECCHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCEE
YPLKNSVHSIKNSDNITFSAISDNKTNNIFWFVENELIATAKPNEAVIWKAKAGEFIIRA
ECCHHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCEEEEEECCCCEEEEE
ISDSGESDSIKIYIKE
ECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]