Click here to switch to the map view.

The map label for this gene is queD [H]

Identifier: 15892148

GI number: 15892148

Start: 232040

End: 232558

Strand: Reverse

Name: queD [H]

Synonym: RC0225

Alternate gene names: 15892148

Gene position: 232558-232040 (Counterclockwise)

Preceding gene: 15892149

Following gene: 15892147

Centisome position: 18.33

GC content: 33.14

Gene sequence:

>519_bases
TTGCTTCGTCAATTACTTCGTAATTTTCCTCACAATGACGTGGTCCCGTTTTTACTCTTTGAAAAAAAAGTAAAATCATT
CAAAGAAAGGAAGTATATAATAATGATAAAATGTACTCGTCGTATTGAGTTCGATGCAGGACATAGAATTATAGAACATC
AAAATAAATGTCAATTCCTGCACGGTCATCGCTATGTTCTTGAGATCGCTATAGCCGCAAACAAAACCGATAAACTTGGT
ATGGTAATCGATTTTGGTTTAATTAAGGATTTAGCTAAAAAATGGATTGATGAAAATTTTGATCATAGCTTAATCCTACA
TCAAGACGATAAGGAAATGGGGCAGCAAATAGAAAATTGTACCGGTCAAAAAATATATTACATGCAAAATAACCCGACTG
CAGAAAATATAGCGACGCATTTAAAGAATGAAATTTTTCCTAAACTTTTCGTGAGTCAAAACTTCTTCGTAACTAGCCTC
AAACTATATGAAACACCGAATTGTTTTGTTGAGGTTTAG

Upstream 100 bases:

>100_bases
GAGAATCCTGAAAAGTTATTGTTAAATTTGTAAAAAATTGTCATTGCGAGCAGCCGTAGGCTGCGTGGCAATCTCATGAA
ATCATAACAAACTCCTGAGA

Downstream 100 bases:

>100_bases
GCATGCAAGATTGCTGTTTAATTTTAACTACTACTAATGATTTGCAAATTGCCGAGAAAATAGCATCTGTTTTGTTAGAA
TTAAATCTTACTGCCTGCAT

Product: hypothetical protein

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: CPH4 synthase; Queuosine biosynthesis protein queD [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MLRQLLRNFPHNDVVPFLLFEKKVKSFKERKYIIMIKCTRRIEFDAGHRIIEHQNKCQFLHGHRYVLEIAIAANKTDKLG
MVIDFGLIKDLAKKWIDENFDHSLILHQDDKEMGQQIENCTGQKIYYMQNNPTAENIATHLKNEIFPKLFVSQNFFVTSL
KLYETPNCFVEV

Sequences:

>Translated_172_residues
MLRQLLRNFPHNDVVPFLLFEKKVKSFKERKYIIMIKCTRRIEFDAGHRIIEHQNKCQFLHGHRYVLEIAIAANKTDKLG
MVIDFGLIKDLAKKWIDENFDHSLILHQDDKEMGQQIENCTGQKIYYMQNNPTAENIATHLKNEIFPKLFVSQNFFVTSL
KLYETPNCFVEV
>Mature_172_residues
MLRQLLRNFPHNDVVPFLLFEKKVKSFKERKYIIMIKCTRRIEFDAGHRIIEHQNKCQFLHGHRYVLEIAIAANKTDKLG
MVIDFGLIKDLAKKWIDENFDHSLILHQDDKEMGQQIENCTGQKIYYMQNNPTAENIATHLKNEIFPKLFVSQNFFVTSL
KLYETPNCFVEV

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde [H]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTPS family. QueD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007115 [H]

Pfam domain/function: PF01242 PTPS [H]

EC number: 4.2.3.12

Molecular weight: Translated: 20374; Mature: 20374

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRQLLRNFPHNDVVPFLLFEKKVKSFKERKYIIMIKCTRRIEFDAGHRIIEHQNKCQFL
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECEEECCCCCHHHHCCCCCEEE
HGHRYVLEIAIAANKTDKLGMVIDFGLIKDLAKKWIDENFDHSLILHQDDKEMGQQIENC
CCCEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCC
TGQKIYYMQNNPTAENIATHLKNEIFPKLFVSQNFFVTSLKLYETPNCFVEV
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCEEEEC
>Mature Secondary Structure
MLRQLLRNFPHNDVVPFLLFEKKVKSFKERKYIIMIKCTRRIEFDAGHRIIEHQNKCQFL
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECEEECCCCCHHHHCCCCCEEE
HGHRYVLEIAIAANKTDKLGMVIDFGLIKDLAKKWIDENFDHSLILHQDDKEMGQQIENC
CCCEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCC
TGQKIYYMQNNPTAENIATHLKNEIFPKLFVSQNFFVTSLKLYETPNCFVEV
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]