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The map label for this gene is folKP [H]

Identifier: 15891960

GI number: 15891960

Start: 35416

End: 35838

Strand: Reverse

Name: folKP [H]

Synonym: RC0037

Alternate gene names: 15891960

Gene position: 35838-35416 (Counterclockwise)

Preceding gene: 15891961

Following gene: 15891959

Centisome position: 2.82

GC content: 32.86

Gene sequence:

>423_bases
TTGAGCTTAACAAAGATTGAAAAACAACTAGGTCGAGTAAGCTCTTACGATAAATGGTCTCCAAGAGTTATTGACTTAGA
TATCCTACTTTGGAATAATTGCCATATAGATTTACCTGATTTAAAGATACCGCATCCTGAATTATTAAACAGACCGTTTC
TTATTCATCTAATTGCAGGTTTAAGCTTGGAATGTCGTTATTCATGTCCGATCAATAATTTTTACAACAATAAAACCTTT
GCAGCAATAGCACATTTAATTGAACATCAAGGAGTTATACGCTCTCTTGTTTTAAATCCTCAATTTGTCGGTATTTTAAA
CATTACTCCTGATTCTTTTTCTGATGGAGGATTGAGTTTTCATGAAGAAGATGCCGTTAGAAATTTTGTACGCTTGATAA
ATGAAGGGGCTACAATAAATTGA

Upstream 100 bases:

>100_bases
CAAGCTATTCTACAACCTAATGCAGATAAAGCTTGGGATAAATCATATTTAAATATGGTGGTGCAGGGCAAAAGTACTTT
AACGCCTAGTAAACTTCTAA

Downstream 100 bases:

>100_bases
GCTTGGATCACAATCAACACGTCCTTCTGCTTTAATTATTAATGAAGATGAAGAATATGCAAGGCTTAATAATGTTCTTG
AAGAGCTTAAGGAAGTTATA

Product: putative folate synthesis bifunctional protein

Products: NA

Alternate protein names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; Dihydropteroate synthase; DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MSLTKIEKQLGRVSSYDKWSPRVIDLDILLWNNCHIDLPDLKIPHPELLNRPFLIHLIAGLSLECRYSCPINNFYNNKTF
AAIAHLIEHQGVIRSLVLNPQFVGILNITPDSFSDGGLSFHEEDAVRNFVRLINEGATIN

Sequences:

>Translated_140_residues
MSLTKIEKQLGRVSSYDKWSPRVIDLDILLWNNCHIDLPDLKIPHPELLNRPFLIHLIAGLSLECRYSCPINNFYNNKTF
AAIAHLIEHQGVIRSLVLNPQFVGILNITPDSFSDGGLSFHEEDAVRNFVRLINEGATIN
>Mature_139_residues
SLTKIEKQLGRVSSYDKWSPRVIDLDILLWNNCHIDLPDLKIPHPELLNRPFLIHLIAGLSLECRYSCPINNFYNNKTFA
AIAHLIEHQGVIRSLVLNPQFVGILNITPDSFSDGGLSFHEEDAVRNFVRLINEGATIN

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000550
- InterPro:   IPR000489 [H]

Pfam domain/function: PF01288 HPPK; PF00809 Pterin_bind [H]

EC number: =2.7.6.3; =2.5.1.15 [H]

Molecular weight: Translated: 15906; Mature: 15774

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTKIEKQLGRVSSYDKWSPRVIDLDILLWNNCHIDLPDLKIPHPELLNRPFLIHLIAG
CCHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCEEECCCCCCCCHHHHCCCCEEEHHHC
LSLECRYSCPINNFYNNKTFAAIAHLIEHQGVIRSLVLNPQFVGILNITPDSFSDGGLSF
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
HEEDAVRNFVRLINEGATIN
CHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SLTKIEKQLGRVSSYDKWSPRVIDLDILLWNNCHIDLPDLKIPHPELLNRPFLIHLIAG
CHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCEEECCCCCCCCHHHHCCCCEEEHHHC
LSLECRYSCPINNFYNNKTFAAIAHLIEHQGVIRSLVLNPQFVGILNITPDSFSDGGLSF
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
HEEDAVRNFVRLINEGATIN
CHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]