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The map label for this gene is norG [H]

Identifier: 57652455

GI number: 57652455

Start: 103121

End: 104518

Strand: Direct

Name: norG [H]

Synonym: SACOL0091

Alternate gene names: 57652455

Gene position: 103121-104518 (Clockwise)

Preceding gene: 57652451

Following gene: 57652456

Centisome position: 3.67

GC content: 29.04

Gene sequence:

>1398_bases
ATGGCTAAATATAAAGATATTGCTAGTGACATAAGAGATAAAATAATCACAGGGGATTGGTTTTATGGAATGAAAATACC
TTCACATAGGCAGTTGGCGATACAGTACAACGTAAATAGAGTAACGATTATTAAAAGTATTGAGTTATTAGAAGCTGAAG
GATTTATCTATACTAAAGTAGGTAGTGGAACATATGTTAATGACTATTTGAATGAAGCACATATTACAAATAAGTGGTCT
GAAATGATGTTATGGTCCTCTCAACAAAGAAGTCAGTATACGGTGCAATTAATTAATAAAATTGAGACAGATGATTCGTA
TATACATATAAGTAAAGGTGAATTGGGTATATCGTTAATGCCACATATTCAATTGAAAAAAGCCATGTCTAATACAGCCA
GTCATATTGAAGACTTATCTTTTGGTTATAATAATGGCTATGGTTATATCAAGTTAAGAGATATTATCGTTGAACGAATG
TCAAAGCAAGGTATAAATGTAGGTAGAGAAAATGTAATGATCACTTCAGGCGCTTTACATGCCATTCAACTTTTATCTAT
TGGGTTTTTAGGTCAAGATGCCATAATAATTTCGAATACACCATCATATATTCACTCTACAAATGTTTTTGAGCAATTGA
ATTTTAGACATATTGATGTTCCTTATAATCAAATTAATGAAATTGATACCATCATTGATAGATTTATTAATTTTAAAAAT
AAAGCGATTTATATAGAACCTAGGTTTAATAACCCGACAGGTCGTTCTTTAACGAATGAGCAAAAGAAAAATATAATTAC
TTATAGCGAAAGACATAATATTCCTATCATTGAAGATGATATCTTTAGAGATATTTTCTTTAGCGATCCAACTCCTTCTA
TCAAAACTTATGATAAATTGGGAAAAGTTATACATATAAGCAGTTTTTCAAAAACGATTGCACCAGCAATAAGAATAGGT
TGGATTGTTGCTTCTGAAAAAATAATAGAGCAATTGGCAGATGTAAGAATGCAAATTGACTATGGATCCAGTATTTTGTC
ACAAATGGTTGTATATGAGATGTTGAAAAATAAGTCTTATGATAAACACTTAGTAAAGTTAAGGTATGTTTTAAAAGATA
AACGAGACTTTATGTTAAACATCCTCAATAATTTATTTAAGGATATAGCACATTGGGAGGTTCCAAGTGGAGGTTATTTT
GTATGGTTAGTCTTTAAAATAGATATAGATATTAAATATTTATTTTACGAATTGTTAAGTAAAGAAAAAATATTAATCAA
TCCGGGTTACATTTATGGCAGTAAAGAAAAGAGTATAAGGCTATCTTTTGCCTTTGAATCAAATGAAAATATTAAGCATG
CGCTCTATAAAATTTATACATATGTGAAAAAGGTTTAA

Upstream 100 bases:

>100_bases
TCCTTTAATTATGTGTTTCTATATTAAAAAATATGATTTAAAATGAGTACAACCAATTTTGAATGGATTTACCTATCCAA
TTTTAAAAGGGAGGGAGAAG

Downstream 100 bases:

>100_bases
TTAAAACAATAATTCGAATCATTATGTGGCATGTTAAACAGCTAAATATAAGCTATGCACATTTAACAAGCGGATACTCC
TGACGCAATTATAGTATCAT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MAKYKDIASDIRDKIITGDWFYGMKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWS
EMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERM
SKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKN
KAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKLGKVIHISSFSKTIAPAIRIG
WIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYF
VWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV

Sequences:

>Translated_465_residues
MAKYKDIASDIRDKIITGDWFYGMKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWS
EMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERM
SKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKN
KAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKLGKVIHISSFSKTIAPAIRIG
WIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYF
VWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
>Mature_464_residues
AKYKDIASDIRDKIITGDWFYGMKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSE
MMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMS
KQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKNK
AIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKLGKVIHISSFSKTIAPAIRIGW
IVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFV
WLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV

Specific function: Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Could also have an aminotransferase activity [H]

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=318, Percent_Identity=25.1572327044025, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI33469970, Length=318, Percent_Identity=25.1572327044025, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787710, Length=484, Percent_Identity=25, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1790797, Length=468, Percent_Identity=23.5042735042735, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321000, Length=181, Percent_Identity=23.7569060773481, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=276, Percent_Identity=25.7246376811594, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356535, Length=335, Percent_Identity=22.089552238806, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 53993; Mature: 53862

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50949 HTH_GNTR ; PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYKDIASDIRDKIITGDWFYGMKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKV
CCCHHHHHHHHHHHEECCCEEEEEECCCCCEEEEEECCCEEEEEEEEEEEECCCEEEEEE
GSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLM
CCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEC
PHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALH
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCEEEECCHHH
AIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKN
HHHHHHHCCCCCCEEEEECCCCHHCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCC
KAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKL
CEEEEEECCCCCCCCCCCCHHHCCEEEEECCCCCCEECHHHHHHHHCCCCCCCCHHHHHC
GKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSY
CCEEEEECHHHHHHHHHHHEEEEHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCC
DKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLS
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHC
KEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
CCEEEECCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKYKDIASDIRDKIITGDWFYGMKIPSHRQLAIQYNVNRVTIIKSIELLEAEGFIYTKV
CCHHHHHHHHHHHEECCCEEEEEECCCCCEEEEEECCCEEEEEEEEEEEECCCEEEEEE
GSGTYVNDYLNEAHITNKWSEMMLWSSQQRSQYTVQLINKIETDDSYIHISKGELGISLM
CCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEC
PHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALH
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCEEEECCHHH
AIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDVPYNQINEIDTIIDRFINFKN
HHHHHHHCCCCCCEEEEECCCCHHCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCC
KAIYIEPRFNNPTGRSLTNEQKKNIITYSERHNIPIIEDDIFRDIFFSDPTPSIKTYDKL
CEEEEEECCCCCCCCCCCCHHHCCEEEEECCCCCCEECHHHHHHHHCCCCCCCCHHHHHC
GKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSY
CCEEEEECHHHHHHHHHHHEEEEHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCC
DKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVPSGGYFVWLVFKIDIDIKYLFYELLS
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHC
KEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
CCEEEECCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA