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The map label for this gene is yrkH [H]

Identifier: 57652415

GI number: 57652415

Start: 53428

End: 54756

Strand: Reverse

Name: yrkH [H]

Synonym: SACOL0046

Alternate gene names: 57652415

Gene position: 54756-53428 (Counterclockwise)

Preceding gene: 57652416

Following gene: 57652413

Centisome position: 1.95

GC content: 33.63

Gene sequence:

>1329_bases
ATGTTTTTTAAACAATTTTATGATAAACATTTATCTCAAGCATCTTATTTAATCGGTTGTCAAAAAACTGGAGAAGCCAT
GATTATTGATCCTATTCGTGACTTATCTTCATATATTCGAGTTGCTGATGAAGAAGGTTTAACCATTACTCATGCAGCTG
AAACACATATACATGCAGATTTTGCTTCAGGAATTAGAGATGTTGCTATAAAGTTAAATGCTAATATTTATGTATCGGGT
GAAAGTGATGACACATTAGGTTATAAAAATATGCCTAACCACACTCATTTTGTTCAACATAATGACGATATTTATGTAGG
AAATATAAAATTAAAAGTGCTTCATACACCGGGTCACACGCCAGAAAGTATAAGTTTTTTACTTACTGACGAAGGTGCTG
GAGCACAAGTTCCAATGGGACTATTCAGTGGTGATTTTATTTTTGTAGGAGATATCGGTAGACCTGATTTACTAGAAAAA
GCGGTTAAAGTAGAAGGATCATCTGAAATAGGCGCTAAACAAATGTTTAAATCGATTGAAAGTATTAAAGACTTGCCAGA
TTACATTCAAATTTGGCCTGGCCATGGCGCTGGTAGTCCTTGTGGTAAATCTTTAGGTGCTATTCCAACATCTACTCTTG
GCTATGAAAAACAAACGAACTGGGCTTTTTCTGAAAATAACGAAGCTACCTTTATCGATAAACTCATTTCTGACCAACCT
GCACCACCACATCATTTTGCACAAATGAAAAAAATTAATCAATTCGGTATGAATTTATATCAACCTTATACGGTTTATCC
AGCTACAAATACAAACAGATTAACTTTTGATCTCCGCAGTAAGGAGGCTTATCATGGTGGACATATTGAAGGTACAATCA
ATATTCCATATGATAAAAATTTCATCAATCAAATTGGCTGGTATCTAAACTATGATCAAGAAATTAACTTGATTGGAGAC
TATCACCTTGTTTCAAAAGCAACACACACCTTACAACTCATTGGATACGATGATATTGCTGGATATCAATTACCGCAATC
TAAGATTCAAACACGTTCCATTCATAGTGAAGACATTACAGGTAACGAATCACATATATTAGATGTACGTAATGATAATG
AATGGAATAATGGCCACTTATCTCAAGCGGTTCATGTACCACACGGCAAACTTTTAGAAACAGATTTACCTTTCAATAAA
AACGATGTTATTTATGTACACTGTCAGTCTGGCATTAGAAGTTCGATAGCTATTGGTATTTTAGAACACAAAGGTTATCA
CAACATTATTAATGTAAATGAAGGTTATAAAGATATACAACTTTCTTAA

Upstream 100 bases:

>100_bases
ACTACGTGATGATGTAGAATACGGTGGCGTAGGTGCATATATTGGATATACAGAACAAGCTAATCACAATTTATTTATAT
AATTAGAAAGGAATGATATT

Downstream 100 bases:

>100_bases
TATTTATACTAATGAAGAAGGACTATAAGTATTTAGATATAGCTTATAGTCCTTTTTATATTATTGGATAAACTAGTAGT
TAATCATACTTATTTTCATG

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MFFKQFYDKHLSQASYLIGCQKTGEAMIIDPIRDLSSYIRVADEEGLTITHAAETHIHADFASGIRDVAIKLNANIYVSG
ESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVLHTPGHTPESISFLLTDEGAGAQVPMGLFSGDFIFVGDIGRPDLLEK
AVKVEGSSEIGAKQMFKSIESIKDLPDYIQIWPGHGAGSPCGKSLGAIPTSTLGYEKQTNWAFSENNEATFIDKLISDQP
APPHHFAQMKKINQFGMNLYQPYTVYPATNTNRLTFDLRSKEAYHGGHIEGTINIPYDKNFINQIGWYLNYDQEINLIGD
YHLVSKATHTLQLIGYDDIAGYQLPQSKIQTRSIHSEDITGNESHILDVRNDNEWNNGHLSQAVHVPHGKLLETDLPFNK
NDVIYVHCQSGIRSSIAIGILEHKGYHNIINVNEGYKDIQLS

Sequences:

>Translated_442_residues
MFFKQFYDKHLSQASYLIGCQKTGEAMIIDPIRDLSSYIRVADEEGLTITHAAETHIHADFASGIRDVAIKLNANIYVSG
ESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVLHTPGHTPESISFLLTDEGAGAQVPMGLFSGDFIFVGDIGRPDLLEK
AVKVEGSSEIGAKQMFKSIESIKDLPDYIQIWPGHGAGSPCGKSLGAIPTSTLGYEKQTNWAFSENNEATFIDKLISDQP
APPHHFAQMKKINQFGMNLYQPYTVYPATNTNRLTFDLRSKEAYHGGHIEGTINIPYDKNFINQIGWYLNYDQEINLIGD
YHLVSKATHTLQLIGYDDIAGYQLPQSKIQTRSIHSEDITGNESHILDVRNDNEWNNGHLSQAVHVPHGKLLETDLPFNK
NDVIYVHCQSGIRSSIAIGILEHKGYHNIINVNEGYKDIQLS
>Mature_442_residues
MFFKQFYDKHLSQASYLIGCQKTGEAMIIDPIRDLSSYIRVADEEGLTITHAAETHIHADFASGIRDVAIKLNANIYVSG
ESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVLHTPGHTPESISFLLTDEGAGAQVPMGLFSGDFIFVGDIGRPDLLEK
AVKVEGSSEIGAKQMFKSIESIKDLPDYIQIWPGHGAGSPCGKSLGAIPTSTLGYEKQTNWAFSENNEATFIDKLISDQP
APPHHFAQMKKINQFGMNLYQPYTVYPATNTNRLTFDLRSKEAYHGGHIEGTINIPYDKNFINQIGWYLNYDQEINLIGD
YHLVSKATHTLQLIGYDDIAGYQLPQSKIQTRSIHSEDITGNESHILDVRNDNEWNNGHLSQAVHVPHGKLLETDLPFNK
NDVIYVHCQSGIRSSIAIGILEHKGYHNIINVNEGYKDIQLS

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI21703352, Length=214, Percent_Identity=28.9719626168224, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI116642887, Length=214, Percent_Identity=28.9719626168224, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI94538320, Length=180, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI94538322, Length=180, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787158, Length=225, Percent_Identity=28.8888888888889, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538952, Length=196, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330176, Length=200, Percent_Identity=26, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356335, Length=184, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24667711, Length=184, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24667703, Length=184, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 49411; Mature: 49411

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50206 RHODANESE_3 ; PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFKQFYDKHLSQASYLIGCQKTGEAMIIDPIRDLSSYIRVADEEGLTITHAAETHIHAD
CCHHHHHHHHHCCCEEEEEECCCCCEEEECCHHHHHHHHEECCCCCEEEEEECCCEEECH
FASGIRDVAIKLNANIYVSGESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVLHTPGHT
HHCCCEEEEEEEECEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEEEEEEEEECCCCC
PESISFLLTDEGAGAQVPMGLFSGDFIFVGDIGRPDLLEKAVKVEGSSEIGAKQMFKSIE
CCCEEEEEECCCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
SIKDLPDYIQIWPGHGAGSPCGKSLGAIPTSTLGYEKQTNWAFSENNEATFIDKLISDQP
HHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCC
APPHHFAQMKKINQFGMNLYQPYTVYPATNTNRLTFDLRSKEAYHGGHIEGTINIPYDKN
CCCHHHHHHHHHHHHCCHHCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEEEECCCCHH
FINQIGWYLNYDQEINLIGDYHLVSKATHTLQLIGYDDIAGYQLPQSKIQTRSIHSEDIT
HHHHCCCEEECCCEEEEEECCHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCC
GNESHILDVRNDNEWNNGHLSQAVHVPHGKLLETDLPFNKNDVIYVHCQSGIRSSIAIGI
CCCCEEEEECCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCEEEEEECCCCCCEEEEEE
LEHKGYHNIINVNEGYKDIQLS
EECCCCCCEEECCCCCCEEEEC
>Mature Secondary Structure
MFFKQFYDKHLSQASYLIGCQKTGEAMIIDPIRDLSSYIRVADEEGLTITHAAETHIHAD
CCHHHHHHHHHCCCEEEEEECCCCCEEEECCHHHHHHHHEECCCCCEEEEEECCCEEECH
FASGIRDVAIKLNANIYVSGESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVLHTPGHT
HHCCCEEEEEEEECEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEEEEEEEEECCCCC
PESISFLLTDEGAGAQVPMGLFSGDFIFVGDIGRPDLLEKAVKVEGSSEIGAKQMFKSIE
CCCEEEEEECCCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
SIKDLPDYIQIWPGHGAGSPCGKSLGAIPTSTLGYEKQTNWAFSENNEATFIDKLISDQP
HHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCC
APPHHFAQMKKINQFGMNLYQPYTVYPATNTNRLTFDLRSKEAYHGGHIEGTINIPYDKN
CCCHHHHHHHHHHHHCCHHCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEEEECCCCHH
FINQIGWYLNYDQEINLIGDYHLVSKATHTLQLIGYDDIAGYQLPQSKIQTRSIHSEDIT
HHHHCCCEEECCCEEEEEECCHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCC
GNESHILDVRNDNEWNNGHLSQAVHVPHGKLLETDLPFNKNDVIYVHCQSGIRSSIAIGI
CCCCEEEEECCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCEEEEEECCCCCCEEEEEE
LEHKGYHNIINVNEGYKDIQLS
EECCCCCCEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]