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The map label for this gene is yeiR [C]

Identifier: 57652319

GI number: 57652319

Start: 2658416

End: 2659306

Strand: Reverse

Name: yeiR [C]

Synonym: SACOL2598

Alternate gene names: 57652319

Gene position: 2659306-2658416 (Counterclockwise)

Preceding gene: 57652320

Following gene: 57652313

Centisome position: 94.66

GC content: 35.24

Gene sequence:

>891_bases
ATGAAAATAGTTATTATAGGTGGGTTTTTAGGTGGCGGTAAAACGACTGTCTTAAATCATTTGCTCGCTGAATCATTAAA
GGAATCGCTGAAACCAGCAGTCATCATGAATGAATTTGGGAAAATGAGTGTTGATGGTGCCTTAGTATCTGAAGACATAC
CTTTAAGTGAACTGACAGAGGGGTGTATCTGTTGTGCAATGAAAGCAGATGTATCAGAACAGTTACATCAATTATATTTA
AAAGAGCAACCAGACATTGTATTTATTGAATGTAGTGGGATTGCAGAACCGGTCTCTGTCTTAGATGCTTGTTTAACGCC
TATTTTAGCTCCGTTTACAACAATTACACATATGATTGGTGTAATAGACGCAAGCATGTATAAACACATTAAATCATTCC
CTAAAGACATCCAAGGCTTATTTTATGAGCAATTAGCATATTGTTCTGTCTTATTTGTTAATAAAATAGATTCAGCAGAT
GTTGAAACAACGAGCAAACTATTGAAAGATTTAGAAGTTATTAACCCAGAGGCCGATATACAAGTCGGTATGCATGGCAG
CGTCACTTTGCCAATATCAGTTAGACAAATGACAGCAACTTCTGACAATAAACATAAGTCTTTACATCAAATGATTAATC
ATCAATTTGTGCAATCACCAGTCAAATGTACTAAAGCAGAGTTTATAAAACGTTTAGCATGCCTTCCGTCTCATATTTAT
AGGTTGAAAGGGTTTATGACATTTGAAGACACCGCACATACGTATCTCATTCAATTTACACAAGGACAATATGAATTAAC
ACCTGTAGCATTTTCAAAAAAAGTGCCAGAATATTTGGTGCTTATCGGAAAGGGTATTTCAAAAGAAGACTATCAATGTT
TGGAACAGTAG

Upstream 100 bases:

>100_bases
TAAAAAAAATGAACTATAACTGAATATAGAGTCATGTCAGTCAATAGGAGATCTATCTTGGAATATGCTATTCATATGAA
GTATAAGAGGAGAGTCGCAG

Downstream 100 bases:

>100_bases
TGTTTTCAGTGGAAGAGAATGGTTAACATGCCTTCATGTATAATAACGAGTTGATTTGAACGTTTAAGCGTAAATAAAAA
TAAGCTTGGTCAGCCATCAA

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: P47K [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKIVIIGGFLGGGKTTVLNHLLAESLKESLKPAVIMNEFGKMSVDGALVSEDIPLSELTEGCICCAMKADVSEQLHQLYL
KEQPDIVFIECSGIAEPVSVLDACLTPILAPFTTITHMIGVIDASMYKHIKSFPKDIQGLFYEQLAYCSVLFVNKIDSAD
VETTSKLLKDLEVINPEADIQVGMHGSVTLPISVRQMTATSDNKHKSLHQMINHQFVQSPVKCTKAEFIKRLACLPSHIY
RLKGFMTFEDTAHTYLIQFTQGQYELTPVAFSKKVPEYLVLIGKGISKEDYQCLEQ

Sequences:

>Translated_296_residues
MKIVIIGGFLGGGKTTVLNHLLAESLKESLKPAVIMNEFGKMSVDGALVSEDIPLSELTEGCICCAMKADVSEQLHQLYL
KEQPDIVFIECSGIAEPVSVLDACLTPILAPFTTITHMIGVIDASMYKHIKSFPKDIQGLFYEQLAYCSVLFVNKIDSAD
VETTSKLLKDLEVINPEADIQVGMHGSVTLPISVRQMTATSDNKHKSLHQMINHQFVQSPVKCTKAEFIKRLACLPSHIY
RLKGFMTFEDTAHTYLIQFTQGQYELTPVAFSKKVPEYLVLIGKGISKEDYQCLEQ
>Mature_296_residues
MKIVIIGGFLGGGKTTVLNHLLAESLKESLKPAVIMNEFGKMSVDGALVSEDIPLSELTEGCICCAMKADVSEQLHQLYL
KEQPDIVFIECSGIAEPVSVLDACLTPILAPFTTITHMIGVIDASMYKHIKSFPKDIQGLFYEQLAYCSVLFVNKIDSAD
VETTSKLLKDLEVINPEADIQVGMHGSVTLPISVRQMTATSDNKHKSLHQMINHQFVQSPVKCTKAEFIKRLACLPSHIY
RLKGFMTFEDTAHTYLIQFTQGQYELTPVAFSKKVPEYLVLIGKGISKEDYQCLEQ

Specific function: The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=334, Percent_Identity=28.4431137724551, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI223941779, Length=322, Percent_Identity=27.639751552795, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI126722884, Length=334, Percent_Identity=28.4431137724551, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI148727351, Length=334, Percent_Identity=28.4431137724551, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI146231952, Length=337, Percent_Identity=28.7833827893175, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI223941776, Length=326, Percent_Identity=27.9141104294479, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI119120938, Length=303, Percent_Identity=26.7326732673267, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788499, Length=188, Percent_Identity=30.3191489361702, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082430, Length=198, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 32836; Mature: 32836

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVIIGGFLGGGKTTVLNHLLAESLKESLKPAVIMNEFGKMSVDGALVSEDIPLSELTE
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEECCCCCHHHHHH
GCICCAMKADVSEQLHQLYLKEQPDIVFIECSGIAEPVSVLDACLTPILAPFTTITHMIG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIDASMYKHIKSFPKDIQGLFYEQLAYCSVLFVNKIDSADVETTSKLLKDLEVINPEADI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCE
QVGMHGSVTLPISVRQMTATSDNKHKSLHQMINHQFVQSPVKCTKAEFIKRLACLPSHIY
EECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKGFMTFEDTAHTYLIQFTQGQYELTPVAFSKKVPEYLVLIGKGISKEDYQCLEQ
HHHCCEEECCCCCEEEEEEECCCEEEEHHHHHHCCCHHHEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MKIVIIGGFLGGGKTTVLNHLLAESLKESLKPAVIMNEFGKMSVDGALVSEDIPLSELTE
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEECCCCCHHHHHH
GCICCAMKADVSEQLHQLYLKEQPDIVFIECSGIAEPVSVLDACLTPILAPFTTITHMIG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIDASMYKHIKSFPKDIQGLFYEQLAYCSVLFVNKIDSADVETTSKLLKDLEVINPEADI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCE
QVGMHGSVTLPISVRQMTATSDNKHKSLHQMINHQFVQSPVKCTKAEFIKRLACLPSHIY
EECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKGFMTFEDTAHTYLIQFTQGQYELTPVAFSKKVPEYLVLIGKGISKEDYQCLEQ
HHHCCEEECCCCCEEEEEEECCCEEEEHHHHHHCCCHHHEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2013568 [H]