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The map label for this gene is coaBC [H]

Identifier: 57651780

GI number: 57651780

Start: 1231668

End: 1232873

Strand: Direct

Name: coaBC [H]

Synonym: SACOL1223

Alternate gene names: 57651780

Gene position: 1231668-1232873 (Clockwise)

Preceding gene: 57651779

Following gene: 57651781

Centisome position: 43.84

GC content: 34.66

Gene sequence:

>1206_bases
TTGAATATGAAGAAAATATTATTAGCCGTTACAGGTGGCATTGCGGCATATAAAGCAATTGATTTGACAAGTAAGTTAAC
ACAATCTGGGTATGAAGTTCGCGTTATGTTAACGAATCACGCACAAAAATTTGTGACACCATTAGCATTTCAAGCAATAA
GTCGAAATGCTGTTTATACAGATACTTTTATAGAAGAAAATCCTTCAGAAATACAGCATATTGCATTAGGTGATTGGGCA
GATGCAATCATTGTTGCACCTGCAACGGCAAATACAATTGCAAAATTGAGTGTAGGTATTGCTGATGATTTGGTGACATC
AACGTTGCTAGCAACAGAGACACCGAAATTTATTGCGCCTGCTATGAATGTGCATATGTATGAAAATAAACGTACGCAGC
AAAATATTAATATTTTAAAAGAAGATGGGTATCATTTTATCGAACCAGGAAGCGGATTTCTAGCATGTGGTTATGTTGCT
AAAGGACGTATGGAAGAACCGCTTCAAATCGTTTCTGTAATTGATGCTCATTTTCAAAATAGTAATCGTTTAGCTAATAG
TTCATTTCAAGATAAACGCGCATTGGTTACAGCAGGACCAACTATTGAAGTTATCGATCCAGTCAGATTTGTATCCAATC
GTTCTTCTGGAAAAATGGGCTATGCAATAGCTGAAGCATTGCGAAATCGAGGAGCTATCGTGACGTTAGTTGCTGGTCCT
ACAACACTAGAGGATCCAAAAGATATTGAAGTTATTCATGTTCAAAGTGCTGAAGAAATGTTTGAACAAGTGACAAGCCG
ATTTGACGAACAAGATATTGTTGTAAAAGCAGCAGCCGTATCTGACTATACACCGATTGATGTATTAGAACATAAGATGA
AAAAGCAGGATGGTGATTTGTCAGTATCTTTTAAACGTACTAAAGACATTCTTAAATATTTAGGTGAACATAAAACATCA
CAGTATTTAATAGGCTTTGCAGCAGAGACTGAAGATATTGAAAATTATGCACAACAAAAATTACGCAAGAAAAATGCAGA
TGTGATTATTTCAAATAATGTTGGGGATATGTCTATCGGATTTAGTTCTGATGATAATGAATTGACAATGCATTTTAAAA
ATAATGAAAAAGTAAATATCAAGAAAGGAAAAAAAGTAGTATTAGCTGCACAAATTTTAGATGAACTAGAAACTAGGTGG
CAATAA

Upstream 100 bases:

>100_bases
TGTTATAATAATACTAAATTTGTATCTATAAAAAAGTAATGAGCATTTGTGCGCATATGATGATGTAAAGCGTAAATGTC
ATAGTGATATTTAAGGGAGA

Downstream 100 bases:

>100_bases
TGATAGCGAAAGTCATAGTCGATGTCGCGTCGAAGAGCGTTGACTATAAATTTGATTATATAATTCCCGAACAACTCGAA
TCTGTCATCCAACCTGGTGT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MNMKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLAFQAISRNAVYTDTFIEENPSEIQHIALGDWA
DAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVA
KGRMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGP
TTLEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPIDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTS
QYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRW
Q

Sequences:

>Translated_401_residues
MNMKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLAFQAISRNAVYTDTFIEENPSEIQHIALGDWA
DAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVA
KGRMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGP
TTLEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPIDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTS
QYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRW
Q
>Mature_401_residues
MNMKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLAFQAISRNAVYTDTFIEENPSEIQHIALGDWA
DAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVA
KGRMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGP
TTLEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPIDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTS
QYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRW
Q

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=36.7567567567568, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=42.3940149625935, Blast_Score=294, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=37.5, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=33.6787564766839, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=32.0855614973262, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44400; Mature: 44400

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLAFQAISRNAVYT
CCHHEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEE
DTFIEENPSEIQHIALGDWADAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAP
EHHHCCCHHHHHEEEECCCCCEEEECCCCCCCHHHEECCHHHHHHHHHHHHCCCCCHHCC
AMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKGRMEEPLQIVSVIDAHFQN
CCEEEEECCCCCCCCCCEEECCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHCC
SNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGP
CCCCCCCCCCCCCEEEECCCEEEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECC
TTLEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPIDVLEHKMKKQDGDL
CCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCE
SVSFKRTKDILKYLGEHKTSQYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIG
EEEHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEC
FSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ
CCCCCCEEEEEECCCCEEEECCCCEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLAFQAISRNAVYT
CCHHEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEE
DTFIEENPSEIQHIALGDWADAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAP
EHHHCCCHHHHHEEEECCCCCEEEECCCCCCCHHHEECCHHHHHHHHHHHHCCCCCHHCC
AMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKGRMEEPLQIVSVIDAHFQN
CCEEEEECCCCCCCCCCEEECCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHCC
SNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGP
CCCCCCCCCCCCCEEEECCCEEEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECC
TTLEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPIDVLEHKMKKQDGDL
CCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCE
SVSFKRTKDILKYLGEHKTSQYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIG
EEEHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEC
FSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ
CCCCCCEEEEEECCCCEEEECCCCEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]