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The map label for this gene is pyrE

Identifier: 57651774

GI number: 57651774

Start: 1226691

End: 1227302

Strand: Direct

Name: pyrE

Synonym: SACOL1217

Alternate gene names: 57651774

Gene position: 1226691-1227302 (Clockwise)

Preceding gene: 57651773

Following gene: 57651775

Centisome position: 43.66

GC content: 33.01

Gene sequence:

>612_bases
ATGGCTAAAGAAATTGCAAAATCATTATTAGATATTGAAGCTGTAACATTATCACCAAATGATTTATATACATGGAGTTC
AGGTATTAAATCACCGATTTACTGTGATAACCGTGTTACGTTAGGTTATCCTTTAGTTCGAGGCGCAATCCGCGATGGTT
TAATTAACTTAATTAAAGAACACTTTCCTGAAGTAGAAGTTATTTCTGGTACTGCAACAGCTGGTATTCCACATGCAGCT
TTTATTGCTGAAAAATTAAAATTACCAATGAATTATGTTCGTTCATCAAATAAGAGTCATGGTAAGCAAAATCAAATCGA
AGGTGCTAAAAGTGAAGGTAAAAAAGTAGTTGTGATAGAAGATTTAATTTCGACAGGGGGATCTTCAGTCACAGCAGTTG
AAGCCTTAAAACTAGCAGGTGCAGAAGTATTAGGTGTTGTAGCTATCTTTACTTACGGTTTGAAAAAAGCAGATGATACA
TTTAGCAATATTCAACTACCTTTTTACACTTTAAGTGATTACAATGAATTAATTGAAGTAGCTGAAAATGAAGGTAAAAT
TTCTAGTGAAGATATCCAAACATTAGTTGAATGGAGAGACAACTTAGCATAA

Upstream 100 bases:

>100_bases
GACAGCTTGGTTCGACGCATATTGTAGTCGGTAGACCGATTACACAAAGTGACAATCCAGTCGAAAGTTATCATAAAATT
AAAGAAAGTTGGTTAGTATA

Downstream 100 bases:

>100_bases
TATAGACACTAGAAGGAGGAATTCAACAAATGAATGACAAAACATCTAATGATTTATATGGGAAGATAAAACATTGTAAC
GAATTTATCAATCATTCAAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAA
FIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKLAGAEVLGVVAIFTYGLKKADDT
FSNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA

Sequences:

>Translated_203_residues
MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAA
FIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKLAGAEVLGVVAIFTYGLKKADDT
FSNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA
>Mature_202_residues
AKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAAF
IAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKLAGAEVLGVVAIFTYGLKKADDTF
SNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Homo sapiens, GI4507835, Length=184, Percent_Identity=22.2826086956522, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_STAAC (Q5HGM7)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186080.1
- ProteinModelPortal:   Q5HGM7
- SMR:   Q5HGM7
- STRING:   Q5HGM7
- EnsemblBacteria:   EBSTAT00000008418
- GeneID:   3236135
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1217
- TIGR:   SACOL1217
- eggNOG:   COG0461
- GeneTree:   EBGT00050000024029
- HOGENOM:   HBG404341
- OMA:   LPMTYVR
- ProtClustDB:   PRK00455
- BioCyc:   SAUR93062:SACOL1217-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- TIGRFAMs:   TIGR00336

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 22042; Mature: 21911

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00012 PHOSPHOPANTETHEINE ; PS00626 RCC1_2

Important sites: BINDING 94-94 BINDING 98-98 BINDING 100-100 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKE
CHHHHHHHHHHHEEEEECCCCCEECCCCCCCCEEECCEEEECHHHHHHHHHHHHHHHHHH
HFPEVEVISGTATAGIPHAAFIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIE
HCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCHHCCCCEEEEEH
DLISTGGSSVTAVEALKLAGAEVLGVVAIFTYGLKKADDTFSNIQLPFYTLSDYNELIEV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEEEHHHHHHHHHH
AENEGKISSEDIQTLVEWRDNLA
HHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKE
HHHHHHHHHHHEEEEECCCCCEECCCCCCCCEEECCEEEECHHHHHHHHHHHHHHHHHH
HFPEVEVISGTATAGIPHAAFIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIE
HCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCHHCCCCEEEEEH
DLISTGGSSVTAVEALKLAGAEVLGVVAIFTYGLKKADDTFSNIQLPFYTLSDYNELIEV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEEEHHHHHHHHHH
AENEGKISSEDIQTLVEWRDNLA
HHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA