The gene/protein map for NC_000853 is currently unavailable.
Definition Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession NC_002951
Length 2,809,422

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The map label for this gene is pdhB

Identifier: 57651703

GI number: 57651703

Start: 1113186

End: 1114163

Strand: Direct

Name: pdhB

Synonym: SACOL1103

Alternate gene names: 57651703

Gene position: 1113186-1114163 (Clockwise)

Preceding gene: 57651702

Following gene: 57651704

Centisome position: 39.62

GC content: 38.34

Gene sequence:

>978_bases
ATGGCACAAATGACAATGGTTCAAGCGATTAATGATGCGCTTAAAACTGAACTTAAAAATGACCAAGATGTTTTAATTTT
TGGTGAAGACGTTGGTGTTAACGGCGGTGTTTTCCGTGTTACTGAAGGACTACAAAAAGAATTTGGTGAAGATAGAGTAT
TCGATACACCTTTAGCTGAATCAGGTATTGGTGGTTTAGCGATGGGTCTTGCAGTTGAAGGATTCCGTCCGGTTATGGAA
GTACAATTCTTAGGTTTCGTATTCGAAGTATTTGATGCGATTGCTGGACAAATTGCACGTACTCGTTTCCGTTCAGGCGG
TACTAAAACTGCACCTGTAACAATTCGTGGACCATTTGGTGGTGGCGTACACACACCAGAATTACACGCAGATAACTTAG
AAGGTATTTTAGCTCAATCTCCAGGTCTAAAGGTTGTTATTCCTTCAGGCCCATACGATGCGAAAGGTTTATTAATTTCT
TCTATTAGAAGTAATGACCCAGTCGTATACTTAGAGCATATGAAATTGTATCGTTCATTCCGTGAAGAAGTACCTGAAGA
AGAATATACAATTGACATTGGTAAGGCTAATGTGAAAAAAGAAGGTAATGACATTTCAATCATCACATACGGTGCAATGG
TTCAAGAATCAATGAAAGCTGCAGAAGAACTTGAAAAAGATGGTTATTCTGTTGAAGTAATTGACTTACGTACTGTTCAA
CCAATCGATGTTGACACAATTGTAGCTTCAGTTGAAAAAACTGGTCGTGCAGTTGTAGTTCAAGAAGCACAACGTCAAGC
TGGTGTTGGTGCAGCAGTTGTAGCTGAATTAAGTGAACGTGCAATCCTTTCATTAGAAGCACCTATTGGAAGAGTTGCAG
CAGCAGATACAATTTATCCATTCACTCAAGCTGAAAATGTTTGGTTACCAAACAAAAATGACATCATCGAAAAAGCAAAA
GAAACTTTAGAATTTTAA

Upstream 100 bases:

>100_bases
ACAAACTGTTACTTCTCTAATGGAAATTATGTATGAAGATATGCCTCAAAACTTAGCAGAACAATATGAAATTTACAAAG
AGAAGGAGTCGAAGTAAGCC

Downstream 100 bases:

>100_bases
TACATTTTAAAAGTTAACGAAGTTAGCGTATTTTAGTCTCATTGATTAAAATGAAATGTTTAATTTACGAAATCTTAGGA
GGGCAAAAACGTGGCATTTG

Product: pyruvate dehydrogenase complex E1 component subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAQMTMVQAINDALKTELKNDQDVLIFGEDVGVNGGVFRVTEGLQKEFGEDRVFDTPLAESGIGGLAMGLAVEGFRPVME
VQFLGFVFEVFDAIAGQIARTRFRSGGTKTAPVTIRGPFGGGVHTPELHADNLEGILAQSPGLKVVIPSGPYDAKGLLIS
SIRSNDPVVYLEHMKLYRSFREEVPEEEYTIDIGKANVKKEGNDISIITYGAMVQESMKAAEELEKDGYSVEVIDLRTVQ
PIDVDTIVASVEKTGRAVVVQEAQRQAGVGAAVVAELSERAILSLEAPIGRVAAADTIYPFTQAENVWLPNKNDIIEKAK
ETLEF

Sequences:

>Translated_325_residues
MAQMTMVQAINDALKTELKNDQDVLIFGEDVGVNGGVFRVTEGLQKEFGEDRVFDTPLAESGIGGLAMGLAVEGFRPVME
VQFLGFVFEVFDAIAGQIARTRFRSGGTKTAPVTIRGPFGGGVHTPELHADNLEGILAQSPGLKVVIPSGPYDAKGLLIS
SIRSNDPVVYLEHMKLYRSFREEVPEEEYTIDIGKANVKKEGNDISIITYGAMVQESMKAAEELEKDGYSVEVIDLRTVQ
PIDVDTIVASVEKTGRAVVVQEAQRQAGVGAAVVAELSERAILSLEAPIGRVAAADTIYPFTQAENVWLPNKNDIIEKAK
ETLEF
>Mature_324_residues
AQMTMVQAINDALKTELKNDQDVLIFGEDVGVNGGVFRVTEGLQKEFGEDRVFDTPLAESGIGGLAMGLAVEGFRPVMEV
QFLGFVFEVFDAIAGQIARTRFRSGGTKTAPVTIRGPFGGGVHTPELHADNLEGILAQSPGLKVVIPSGPYDAKGLLISS
IRSNDPVVYLEHMKLYRSFREEVPEEEYTIDIGKANVKKEGNDISIITYGAMVQESMKAAEELEKDGYSVEVIDLRTVQP
IDVDTIVASVEKTGRAVVVQEAQRQAGVGAAVVAELSERAILSLEAPIGRVAAADTIYPFTQAENVWLPNKNDIIEKAKE
TLEF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=40.9230769230769, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=40.9230769230769, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=37.1165644171779, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=35.2760736196319, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI225637461, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI225637459, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI225637463, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI133778974, Length=97, Percent_Identity=39.1752577319588, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=39.0769230769231, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=36.697247706422, Blast_Score=224, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=39.8773006134969, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=38.9570552147239, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=38.7692307692308, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=38.3435582822086, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=38.3435582822086, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=43.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=43.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645119, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551847, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550715, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ODPB_STAAC (Q5HGZ0)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185967.1
- ProteinModelPortal:   Q5HGZ0
- SMR:   Q5HGZ0
- STRING:   Q5HGZ0
- EnsemblBacteria:   EBSTAT00000008796
- GeneID:   3237846
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1103
- TIGR:   SACOL1103
- eggNOG:   COG0022
- GeneTree:   EBGT00050000024771
- HOGENOM:   HBG753264
- OMA:   AKIHYRT
- ProtClustDB:   CLSK885133
- BioCyc:   SAUR93062:SACOL1103-MONOMER
- GO:   GO:0006096
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =1.2.4.1

Molecular weight: Translated: 35216; Mature: 35085

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: BINDING 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MAQMTMVQAINDALKTELKNDQDVLIFGEDVGVNGGVFRVTEGLQKEFGEDRVFDTPLAE
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHH
SGIGGLAMGLAVEGFRPVMEVQFLGFVFEVFDAIAGQIARTRFRSGGTKTAPVTIRGPFG
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECEEEEECCCC
GGVHTPELHADNLEGILAQSPGLKVVIPSGPYDAKGLLISSIRSNDPVVYLEHMKLYRSF
CCCCCCCCCCCCCCHHEECCCCCEEEECCCCCCCCCCEEEECCCCCCEEEHHHHHHHHHH
REEVPEEEYTIDIGKANVKKEGNDISIITYGAMVQESMKAAEELEKDGYSVEVIDLRTVQ
HHHCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
PIDVDTIVASVEKTGRAVVVQEAQRQAGVGAAVVAELSERAILSLEAPIGRVAAADTIYP
CCCHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHEEEECCCCCHHHHHCCCCC
FTQAENVWLPNKNDIIEKAKETLEF
CCCCCCEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AQMTMVQAINDALKTELKNDQDVLIFGEDVGVNGGVFRVTEGLQKEFGEDRVFDTPLAE
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHH
SGIGGLAMGLAVEGFRPVMEVQFLGFVFEVFDAIAGQIARTRFRSGGTKTAPVTIRGPFG
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECEEEEECCCC
GGVHTPELHADNLEGILAQSPGLKVVIPSGPYDAKGLLISSIRSNDPVVYLEHMKLYRSF
CCCCCCCCCCCCCCHHEECCCCCEEEECCCCCCCCCCEEEECCCCCCEEEHHHHHHHHHH
REEVPEEEYTIDIGKANVKKEGNDISIITYGAMVQESMKAAEELEKDGYSVEVIDLRTVQ
HHHCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
PIDVDTIVASVEKTGRAVVVQEAQRQAGVGAAVVAELSERAILSLEAPIGRVAAADTIYP
CCCHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHEEEECCCCCHHHHHCCCCC
FTQAENVWLPNKNDIIEKAKETLEF
CCCCCCEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA