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The map label for this gene is ggt [H]

Identifier: 57651204

GI number: 57651204

Start: 220341

End: 222347

Strand: Direct

Name: ggt [H]

Synonym: SACOL0188

Alternate gene names: 57651204

Gene position: 220341-222347 (Clockwise)

Preceding gene: 57651203

Following gene: 57651207

Centisome position: 7.84

GC content: 37.62

Gene sequence:

>2007_bases
ATGGTCATTAACTTAAATGACAAACAGACAAAAACATCTAAAGAAGGGTTAATTTCCGTATCACATCCTCTTGCGGCTAA
AATTGGTAAGGATGTATTAGATCAAGGTGGCAACGCCATGGATGCAGTGATTGCAATTCAACTGGCATTGAATGTGGTAG
AACCATTTGCATCAGGTATTGGTGGTGGCGGGTATTTGCTATATTATGAGCAAAGTACTGGCAGTATAACTGCGTTTGAT
GCACGTGAGACAGCACCTGAACATGTAGACAAACAATTTTATCTAGATGATTCAGGCGAATATAAATCATTTTTTGATAT
GACTACACATGGTAAAACTGTCGCTGTGCCAGCAATTCCAAAGCTGTTTGATTATATTCACAAGCGTTATGCTAAATTGT
CATTGGAAGATTTAATTAATCCTGCAATTGAACTAGCCATTGAAGGTCATGCAGCCAATTGGGCTACTGAAAAATATTCG
CGCCAGCAACACGCACGATTGACAAAGTATCATGAAACGGCACAAGTATTTACGCATGAAAATCAATATTGGCGTGAAGG
TGATTGGATTGTACAACCCGAATTAGGTAAGACATTTCAAATATTAAGAGAACAAGGGTTTAATGCATTTTATAAAGGTG
ACATTGCGAAACAATTAGTCAATGTTGTCAAAGCATGTGGTGGGACAATCACTTTAGAGGATCTAGCCAAATATGACATT
CAGATTAAAGCGCCAATCAGTGCAACATTTAAAGACTATGACATTTATTCAATGGGACCATCTAGTTCTGGCGGTATCAC
GGTAATTCAAATATTGAAGTTATTAGAACATGTCGATTTACCATCTATGGGTCCAAGATCTGTTGATTACTTGCATCATT
TGATACAAGCGATGCATTTAGCATATAGTGATCGTGCGCAATACTTGGCGGATGATAATTTTCATGAGGTGCCTGTACAG
TCATTAATTGATGATGATTATTTAAAAGCACGCAGTACGCTCATTGATAGCAATAAAGCAAATATTGATATAGAGCATGG
TGTTGTGTCTGATTGCATTAGTCATACAGATGTTGAAGAAAATCATACCGAAACAACTCATTTTTGTGTGATTGATAAGG
AAGGTAATATTGCTTCATTTACGACATCAATTGGTATGATTTATGGTTCAGGTATCACGATTCCAGGCTACGGTGTGTTA
TTGAATACGACAATGGATGGCTTTGATGTAGTAGATGGTGGTATTAACGAAATTGCACCATATAAACGACCACTAAGTAA
CATGGCTCCAACGATTGTGATGTATCACGGGAAGCCAATATTAACAGTAGGTGCACCTGGTGCCATAAGTATCATTGCTA
GTGTTGCGCAAACATTAATCAATGTATTAGTGTTTGGCATGGATATTCAGCAGGCTATAGATGAACCTAGAATTTATAGT
AGCCATCCTAATCGCATTGAATGGGAGCCTCAATTTTCACAATCTACAATATTAGCATTGATTGCACATGGACATGCAAT
GGAACATAAACCAGATGCTTATATTGGAGATGTACATGGACTACAGGTTGACCCAACAACGTATGAAGCTTCGGGTGGAA
GTGATGATACTAGAGAAGGCACCGTAATGGGTGGCGAGGTGTTAGTGATTAGAAAACAGCCATTACCATATCGGCAAATG
TATGATAGTGACGGCTTTCGTCTATATTTCAATGATGTGCAGTTACCTTTATTGGCAGATCAAGTGCGATGGATGCATGA
CAAATATTGGGTTGATGAAAGTGTTGTTAGAATCATTTTCCCTGAAGTTAGTGCACATATTGAAGATTTAAGAAGTTATG
AAAACGCAGGAGAAAATTATATAGATATTGCCTGGTTAGCACGGAAATATGCTTATCAAGTAACATTGAAGGATGACGGT
TTATACTTAACTGATGATACATATACTTCAGTGAAACGGAACACAAATGCATACTATAGATATGATCGAGATAGTATCAC
AAGATAG

Upstream 100 bases:

>100_bases
GTCGATACTGGTAACGAGCAACGTCAAGATTTAGAAAAAGTAGAAAAAGCCATTAATCAATAATGTTTTAAATATTTAAC
AGAAAGTAGGAGGATATAGT

Downstream 100 bases:

>100_bases
TTTATACGCTTGATATGAAGTTTGTAGTGGATATGAGCTTTTGTTGAATGAAAGGATTCGATTTCGAACTTTAGCGTGAC
GCTTGAGTGTAGTAATGTTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFD
ARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHAANWATEKYS
RQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTITLEDLAKYDI
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQ
SLIDDDYLKARSTLIDSNKANIDIEHGVVSDCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVL
LNTTMDGFDVVDGGINEIAPYKRPLSNMAPTIVMYHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAIDEPRIYS
SHPNRIEWEPQFSQSTILALIAHGHAMEHKPDAYIGDVHGLQVDPTTYEASGGSDDTREGTVMGGEVLVIRKQPLPYRQM
YDSDGFRLYFNDVQLPLLADQVRWMHDKYWVDESVVRIIFPEVSAHIEDLRSYENAGENYIDIAWLARKYAYQVTLKDDG
LYLTDDTYTSVKRNTNAYYRYDRDSITR

Sequences:

>Translated_668_residues
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFD
ARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHAANWATEKYS
RQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTITLEDLAKYDI
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQ
SLIDDDYLKARSTLIDSNKANIDIEHGVVSDCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVL
LNTTMDGFDVVDGGINEIAPYKRPLSNMAPTIVMYHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAIDEPRIYS
SHPNRIEWEPQFSQSTILALIAHGHAMEHKPDAYIGDVHGLQVDPTTYEASGGSDDTREGTVMGGEVLVIRKQPLPYRQM
YDSDGFRLYFNDVQLPLLADQVRWMHDKYWVDESVVRIIFPEVSAHIEDLRSYENAGENYIDIAWLARKYAYQVTLKDDG
LYLTDDTYTSVKRNTNAYYRYDRDSITR
>Mature_668_residues
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFD
ARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHAANWATEKYS
RQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTITLEDLAKYDI
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQ
SLIDDDYLKARSTLIDSNKANIDIEHGVVSDCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVL
LNTTMDGFDVVDGGINEIAPYKRPLSNMAPTIVMYHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAIDEPRIYS
SHPNRIEWEPQFSQSTILALIAHGHAMEHKPDAYIGDVHGLQVDPTTYEASGGSDDTREGTVMGGEVLVIRKQPLPYRQM
YDSDGFRLYFNDVQLPLLADQVRWMHDKYWVDESVVRIIFPEVSAHIEDLRSYENAGENYIDIAWLARKYAYQVTLKDDG
LYLTDDTYTSVKRNTNAYYRYDRDSITR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=506, Percent_Identity=28.8537549407115, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI73915090, Length=506, Percent_Identity=28.8537549407115, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI73915096, Length=506, Percent_Identity=28.8537549407115, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI73915094, Length=506, Percent_Identity=28.8537549407115, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI113429324, Length=504, Percent_Identity=27.7777777777778, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI113429326, Length=510, Percent_Identity=28.0392156862745, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI153266885, Length=517, Percent_Identity=25.7253384912959, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI153266901, Length=518, Percent_Identity=25.6756756756757, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI153266907, Length=516, Percent_Identity=24.031007751938, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI109148539, Length=517, Percent_Identity=24.7582205029014, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI30581157, Length=152, Percent_Identity=34.2105263157895, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI30581155, Length=152, Percent_Identity=34.2105263157895, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789856, Length=537, Percent_Identity=34.6368715083799, Blast_Score=311, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI212646519, Length=506, Percent_Identity=30.8300395256917, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI72000294, Length=506, Percent_Identity=30.8300395256917, Blast_Score=188, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI193208245, Length=508, Percent_Identity=31.1023622047244, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193208247, Length=508, Percent_Identity=31.1023622047244, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17506189, Length=522, Percent_Identity=26.4367816091954, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17542894, Length=537, Percent_Identity=27.0018621973929, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI72001497, Length=264, Percent_Identity=25, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI72001495, Length=264, Percent_Identity=25, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323330, Length=510, Percent_Identity=29.6078431372549, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI161077878, Length=519, Percent_Identity=27.9383429672447, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI161077496, Length=525, Percent_Identity=27.047619047619, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24642670, Length=519, Percent_Identity=27.9383429672447, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24642666, Length=519, Percent_Identity=27.9383429672447, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45551474, Length=519, Percent_Identity=27.9383429672447, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI161077880, Length=519, Percent_Identity=27.9383429672447, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI18859893, Length=538, Percent_Identity=27.8810408921933, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI18859741, Length=523, Percent_Identity=26.9598470363289, Blast_Score=151, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 74695; Mature: 74695

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGI
CEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
GGGGYLLYYEQSTGSITAFDARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIP
CCCEEEEEEECCCCCEEEECCCCCCHHHCCCEEEECCCCCCCHHEEEECCCCEEECCCHH
KLFDYIHKRYAKLSLEDLINPAIELAIEGHAANWATEKYSRQQHARLTKYHETAQVFTHE
HHHHHHHHHHHHCCHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECC
NQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTITLEDLAKYDI
CCCEECCCEEECCCCCHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCEEEHHHHHHCCE
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHL
EEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AYSDRAQYLADDNFHEVPVQSLIDDDYLKARSTLIDSNKANIDIEHGVVSDCISHTDVEE
HHHCCHHHHCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCCCC
NHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVLLNTTMDGFDVVDGGINEIAP
CCCCCEEEEEEECCCCEEEEHHHEEEEEECCCCCCCCCEEEECCCCCCHHCCCCHHHCCC
YKRPLSNMAPTIVMYHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAIDEPRIYS
CCCCHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
SHPNRIEWEPQFSQSTILALIAHGHAMEHKPDAYIGDVHGLQVDPTTYEASGGSDDTREG
CCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCEEECCCEEECCCCCCCCCCC
TVMGGEVLVIRKQPLPYRQMYDSDGFRLYFNDVQLPLLADQVRWMHDKYWVDESVVRIIF
EEECCEEEEEECCCCCHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHEEEE
PEVSAHIEDLRSYENAGENYIDIAWLARKYAYQVTLKDDGLYLTDDTYTSVKRNTNAYYR
HHHHHHHHHHHHHHHCCCCEEEHHHHHEEEEEEEEEECCCEEEECCCHHHHHCCCCCEEE
YDRDSITR
ECCCCCCC
>Mature Secondary Structure
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGI
CEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
GGGGYLLYYEQSTGSITAFDARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIP
CCCEEEEEEECCCCCEEEECCCCCCHHHCCCEEEECCCCCCCHHEEEECCCCEEECCCHH
KLFDYIHKRYAKLSLEDLINPAIELAIEGHAANWATEKYSRQQHARLTKYHETAQVFTHE
HHHHHHHHHHHHCCHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECC
NQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTITLEDLAKYDI
CCCEECCCEEECCCCCHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCEEEHHHHHHCCE
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHL
EEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AYSDRAQYLADDNFHEVPVQSLIDDDYLKARSTLIDSNKANIDIEHGVVSDCISHTDVEE
HHHCCHHHHCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCCCC
NHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVLLNTTMDGFDVVDGGINEIAP
CCCCCEEEEEEECCCCEEEEHHHEEEEEECCCCCCCCCEEEECCCCCCHHCCCCHHHCCC
YKRPLSNMAPTIVMYHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAIDEPRIYS
CCCCHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
SHPNRIEWEPQFSQSTILALIAHGHAMEHKPDAYIGDVHGLQVDPTTYEASGGSDDTREG
CCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCEEECCCEEECCCCCCCCCCC
TVMGGEVLVIRKQPLPYRQMYDSDGFRLYFNDVQLPLLADQVRWMHDKYWVDESVVRIIF
EEECCEEEEEECCCCCHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHEEEE
PEVSAHIEDLRSYENAGENYIDIAWLARKYAYQVTLKDDGLYLTDDTYTSVKRNTNAYYR
HHHHHHHHHHHHHHHCCCCEEEHHHHHEEEEEEEEEECCCEEEECCCHHHHHCCCCCEEE
YDRDSITR
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA