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The map label for this gene is hisD

Identifier: 57651070

GI number: 57651070

Start: 2774492

End: 2775748

Strand: Reverse

Name: hisD

Synonym: SACOL2702

Alternate gene names: 57651070

Gene position: 2775748-2774492 (Counterclockwise)

Preceding gene: 57651071

Following gene: 57651069

Centisome position: 98.8

GC content: 35.72

Gene sequence:

>1257_bases
TTGCCAATGCTTAATGCACAACAATTTTTAAATCAATTTTCATTAGAAGCACCATTAGATGAGTCATTGTATCCAATTAT
TCGCGATATTTGTCAGGAAGTTAAAGTTCATGGAGATAAGGCTTTGAAAATGTATAATCTAACATTCGATCATACGAAAA
CAGATCATTTAGAAATTAGTCATGAACAAATTAAAGCAGCATTTGACACATTAGATGAAAAAACAAAACAAGCATTACAA
CAAAGTTATGAAAGAATTAAAGCATATCAAGAAAGTATTAAACAGACGAATCAACAGTTAGAAGAATCAGTGGAGTGTTA
TGAAATATACCATCCACTAGAAAGTGTCGGTATTTATGTGCCTGGTGGTAAAGCAAGTTATCCTTCAACGGTATTAATGA
CAGCGACGTTAGCACAAGTAGCAGGTGTGGAAAATATTGTCGTTGTGACACCACCTCAACCTAATGGTGTGTCTCAAGAA
GTATTAGCAGCATGCTATATTACGCAAGTTGATCAAGTATTTCAAGTTGGTGGTGCTCAAAGTATTGCTGCGTTAACTTA
TGGCACAGAAACGATACCTAAAGTTGATAAGATTGTAGGTCCAGGCAATCAATTTGTTGCATATGCCAAGAAATATTTAT
TTGGACAAGTAGGTATTGACCAAATAGCTGGACCAACAGAAATAGCACTTATTATTGATGAAACAGCAGATTTAGATGCC
ATCGTATATGATGTTTTTGCACAAGCAGAACATGATGAATTAGCACGTACATATGCCATTAGTGAAGATGCGCAAGTCCT
TAAAGATTTAGAATCACGTATTGCTAAAGCATTGCCTAATGTGGACAGATACGACATTGTTTCTAAAAGTATCGCTAATC
AACACTACCTTATCCATGCTAGTAATTTTGATGAAGCATGCCATGTCATGAATACAATCGCGCCTGAACATGCGTCGATT
CAAACAGTAAATCCTCAACCATATATTGAAAAAGTGAAATATGTGGGTGCATTGTTTATTGGACATTATTCGCCAGAGGT
CATAGGAGATTACGTTGCAGGTCCAAGTCATGTATTACCTACAAATAGAACAGCTAGATTTACCAATGGGTTATCGGTCA
ATGATTTCTTAACACGGAACACGGTCATCCATTTATCAAAAGATACGTTTGAACAAATTGCTGATTCAGCACAACATATT
GCTCATGTTGAAGCATTATACAATCACCAGCAGTCTATTTTAATACGTCAGTCTTAG

Upstream 100 bases:

>100_bases
CATATTAGTGATATCAATGCAAGATTAATAACTAATAAAGCAGCTTATTTTAAAAAATCACAATTAATAGAGCAATTTAT
TCGCTCTTTGGAGGTGTCTA

Downstream 100 bases:

>100_bases
GGGAGTGTAATTGAAATGATTTATATTGATAAAAATGAAAGTCCAGTTACGCCGTTGGATGAAAAAACAATGACGTCTAT
TATTAGTGCAACGCCATATA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPMLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQ
QSYERIKAYQESIKQTNQQLEESVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQE
VLAACYITQVDQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDETADLDA
IVYDVFAQAEHDELARTYAISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACHVMNTIAPEHASI
QTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHI
AHVEALYNHQQSILIRQS

Sequences:

>Translated_418_residues
MPMLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQ
QSYERIKAYQESIKQTNQQLEESVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQE
VLAACYITQVDQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDETADLDA
IVYDVFAQAEHDELARTYAISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACHVMNTIAPEHASI
QTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHI
AHVEALYNHQQSILIRQS
>Mature_417_residues
PMLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQ
SYERIKAYQESIKQTNQQLEESVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEV
LAACYITQVDQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDETADLDAI
VYDVFAQAEHDELARTYAISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACHVMNTIAPEHASIQ
TVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIA
HVEALYNHQQSILIRQS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=34.6987951807229, Blast_Score=263, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=33.5714285714286, Blast_Score=227, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_STAAC (Q5HCL9)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187488.1
- ProteinModelPortal:   Q5HCL9
- SMR:   Q5HCL9
- STRING:   Q5HCL9
- EnsemblBacteria:   EBSTAT00000010541
- GeneID:   3238670
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2702
- TIGR:   SACOL2702
- eggNOG:   COG0141
- GeneTree:   EBGT00050000024764
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK13770
- BioCyc:   SAUR93062:SACOL2702-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46407; Mature: 46276

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 316-316 ACT_SITE 317-317 BINDING 119-119 BINDING 180-180 BINDING 203-203 BINDING 226-226 BINDING 248-248 BINDING 251-251 BINDING 317-317 BINDING 350-350 BINDING 404-404 BINDING 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEIS
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEECC
HEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEESVECYEIYHPLESVGIYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEE
PGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVDQVFQVGGAQ
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
SIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDETADLDA
CEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCHHH
IVYDVFAQAEHDELARTYAISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHA
HHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEE
SNFDEACHVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLP
CCHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCC
TNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAHVEALYNHQQSILIRQS
CCCCCCCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
PMLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEIS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEECC
HEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEESVECYEIYHPLESVGIYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEE
PGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVDQVFQVGGAQ
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
SIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDETADLDA
CEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCHHH
IVYDVFAQAEHDELARTYAISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHA
HHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEE
SNFDEACHVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLP
CCHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCC
TNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAHVEALYNHQQSILIRQS
CCCCCCCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA