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The map label for this gene is hisI

Identifier: 57651064

GI number: 57651064

Start: 2770260

End: 2770892

Strand: Reverse

Name: hisI

Synonym: SACOL2696

Alternate gene names: 57651064

Gene position: 2770892-2770260 (Counterclockwise)

Preceding gene: 57651065

Following gene: 57651063

Centisome position: 98.63

GC content: 34.91

Gene sequence:

>633_bases
ATGACCAACTATAAAATTGATTTTAGCAAAGGTTTAGTGCCAGCAATTTTACAAGATAATCAAACAAAACAAGTATTGAT
GTTGGGTTATATGAACCAAGAAGCTTTTGATAAAACGATAGAAGATGGTGTGGTATGTTTCTATTCGCGGTCGAAACAAC
GGCTATGGACAAAAGGTGAAACATCTGGTCATACGCAACGTGTTAAAGATATTCATGTAGATTGCGACAATGACACTATT
TTAATTGATGTCATACCAAATGGACCAACATGTCATACAGGCAGTCAAAGTTGTTTCAACACAGAAGTTCCATTTTCAGT
GCAAACATTAGCGCAGACAGTTCAAGATAGTGCCCAATCCAATAATGAAAAGTCATATACAAAATATTTATTAACAGAAG
GTATAGAAAAGATTACAAAAAAATACGGTGAAGAAGCTTTTGAAGTCGTAATTGAAGCAATTAAAGGTGACAAAAAAGCA
TTTGTAAGTGAAGTAGCAGATGAACTTTATCATTTATTTGTCTTGATGCATGCGCTTGGCGTCGATTTTTCAGAAATTGA
GGCGGAATTAGCGCGTAGACATCATAAGCGCAATAACTTTAAAGGTGAACGACAAAATATCGAACAGTGGTAA

Upstream 100 bases:

>100_bases
CGGATGTTTCTGCAGGTTTAGCTGCAAGTATATTACATGATCGAGAAACGACGGTTCAATCTATTAAAGAAGTGATACGG
CAAGGGGGTATAGCAGTAAG

Downstream 100 bases:

>100_bases
AGCAAGTATGGACTAAGATATAAGGAAAAGGATCATGGCTTATACACTTACAAATATTGTGGAAAACGTGACATTTTCAA
GTTTAAAATACGACACCAAC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTI
LIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKA
FVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW

Sequences:

>Translated_210_residues
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTI
LIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKA
FVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW
>Mature_209_residues
TNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTIL
IDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAF
VSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=43.5897435897436, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319819, Length=200, Percent_Identity=33, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_STAAC (Q5HCM5)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187482.1
- ProteinModelPortal:   Q5HCM5
- STRING:   Q5HCM5
- EnsemblBacteria:   EBSTAT00000009053
- GeneID:   3238363
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2696
- TIGR:   SACOL2696
- eggNOG:   COG0139
- GeneTree:   EBGT00050000024241
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- ProtClustDB:   PRK02759
- BioCyc:   SAUR93062:SACOL2696-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 23973; Mature: 23842

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGE
CCCCEEECCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHCCCCC
TSGHTQRVKDIHVDCDNDTILIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQS
CCCCHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
NNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
VDFSEIEAELARRHHKRNNFKGERQNIEQW
CCHHHHHHHHHHHHHHHCCCCCCHHCCCCC
>Mature Secondary Structure 
TNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGE
CCCEEECCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHCCCCC
TSGHTQRVKDIHVDCDNDTILIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQS
CCCCHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
NNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
VDFSEIEAELARRHHKRNNFKGERQNIEQW
CCHHHHHHHHHHHHHHHCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA