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The map label for this gene is mvaA [H]

Identifier: 57651056

GI number: 57651056

Start: 2618093

End: 2619370

Strand: Reverse

Name: mvaA [H]

Synonym: SACOL2560

Alternate gene names: 57651056

Gene position: 2619370-2618093 (Counterclockwise)

Preceding gene: 57651058

Following gene: 57651055

Centisome position: 93.24

GC content: 38.89

Gene sequence:

>1278_bases
ATGCAAAATTTAGATAAGAATTTTCGACATTTATCTCGTAAAGAAAAGTTACAACAATTGGTTGATAAGCAATGGTTATC
AGAAGAACAATTCGACATTTTACTGAATCATCCATTAATCGATGAAGAAGTAGCCAATAGTTTAATTGAAAATGTCATCG
CGCAAGGTGCATTACCCGTTGGATTATTACCGAATATCATTGTGGACGATAAGGCATATGTTGTACCTATGATGGTGGAA
GAGCCTTCAGTTGTCGCTGCAGCTAGTTATGGTGCAAAGCTAGTGAATCAGACTGGCGGATTTAAAACGGTATCTTCTGA
ACGTATTATGATAGGTCAAATCGTCTTTGATGGCGTTGACGATACTGAAAAATTATCAGCAGACATTAAAGCTTTAGAAA
AGCAAATTCATAAAATTGCGGATGAGGCATATCCTTCTATTAAAGCGCGTGGTGGTGGTTACCAACGTATAGCGATTGAT
ACATTTCCTGAGCAACAGTTACTATCTTTAAAAGTATTTGTTGATACGAAAGATGCTATGGGCGCTAATATGCTTAATAC
GATTTTAGAGGCCATAACTGCATTTTTAAAAAATGAATTTCCGCAAAGCGACATTTTAATGAGTATTTTATCCAATCATG
CAACAGCGTCCGTTGTTAAAGTTCAAGGCGAAATTGATGTTAAAGATTTAGCAAGGGGCGAGAGAACTGGAGAAGAGGTT
GCCAAACGAATGGAACGTGCTTCTGTATTGGCCCAAGTAGATATTCATCGTGCAGCAACACATAATAAAGGTGTTATGAA
TGGCATACATGCTGTTGTTTTAGCAACAGGAAATGATACGCGTGGTGCAGAAGCAAGTGCGCATGCATACGCGAGTCGTG
ACGGACAGTATCGTGGTATTGCTACATGGCGTTACGATCAAGATCGTCAACGATTGATTGGTACAATTGAAGTGCCTATG
ACATTGGCAATCGTTGGCGGTGGTACAAAAGTATTACCAATTGCTAAAGCTTCATTAGAGCTACTAAATGTAGAGTCAGC
ACAAGAATTAGGTCATGTAGTTGCTGCCGTTGGTTTAGCGCAAAACTTTGCAGCATGTCGCGCGCTTGTGTCAGAAGGTA
TTCAACAAGGTCATATGAGTTTACAATATAAATCATTAGCTATCGTTGTAGGGGCAAAAGGTGATGAAATTGCTAAAGTA
GCTGAAGCTTTGAAAAAAGAACCCCGTGCAAATACACAAGCAGCGGAACATATTTTACAAGAAATTAGACAACAATAG

Upstream 100 bases:

>100_bases
CAATTATTCAATTGAATTTTAAGACGAATGACGTTATTTTGTGGTAAAAATAGTAGTGATTGAAATGTTAAAAATTATGT
GAAGTAAAAGGAGTACGTCC

Downstream 100 bases:

>100_bases
TAAATGGCGAATAGCGATTTTAAAGAAAAGTTTAAGTCAGTCCATCGTAGCGCTTAGATAAATTAATATGAACAAAAATA
AAAACTTCTATCACACGCAT

Product: hydroxymethylglutaryl-CoA reductase, degradative

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MQNLDKNFRHLSRKEKLQQLVDKQWLSEEQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQDRQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVESAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAKV
AEALKKEPRANTQAAEHILQEIRQQ

Sequences:

>Translated_425_residues
MQNLDKNFRHLSRKEKLQQLVDKQWLSEEQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQDRQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVESAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAKV
AEALKKEPRANTQAAEHILQEIRQQ
>Mature_425_residues
MQNLDKNFRHLSRKEKLQQLVDKQWLSEEQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQDRQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVESAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAKV
AEALKKEPRANTQAAEHILQEIRQQ

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323483, Length=404, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323565, Length=374, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46238; Mature: 46238

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLDKNFRHLSRKEKLQQLVDKQWLSEEQFDILLNHPLIDEEVANSLIENVIAQGALPV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCC
GLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVD
CCCCCEEECCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCC
DTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAM
CHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCHHHEEEEEEEECCHHC
GANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCHHHH
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGI
HHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCE
ATWRYDQDRQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVESAQELGHVVAAVGLA
EEEECCCCHHHHEEEEECCEEEEEECCCCEEEEEHHHHHHHHCHHHHHHHHHHHHHHHHH
QNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAKVAEALKKEPRANTQAAEHILQ
HHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHH
EIRQQ
HHHCC
>Mature Secondary Structure
MQNLDKNFRHLSRKEKLQQLVDKQWLSEEQFDILLNHPLIDEEVANSLIENVIAQGALPV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCC
GLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVD
CCCCCEEECCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCC
DTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAM
CHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCHHHEEEEEEEECCHHC
GANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCHHHH
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGI
HHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCE
ATWRYDQDRQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVESAQELGHVVAAVGLA
EEEECCCCHHHHEEEEECCEEEEEECCCCEEEEEHHHHHHHHCHHHHHHHHHHHHHHHHH
QNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAKVAEALKKEPRANTQAAEHILQ
HHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHH
EIRQQ
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]