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The map label for this gene is pgcA [H]

Identifier: 57651000

GI number: 57651000

Start: 2554511

End: 2556319

Strand: Direct

Name: pgcA [H]

Synonym: SACOL2501

Alternate gene names: 57651000

Gene position: 2554511-2556319 (Clockwise)

Preceding gene: 57650991

Following gene: 57651001

Centisome position: 90.93

GC content: 34.0

Gene sequence:

>1809_bases
ATGCATTTTCATACACATCTATTATATAATACTTGTGAAAAGTATTGTCTTGGGGCTGTGTTTTTTTACTTTTGGGGCGT
ATTTCTTTATAATTCATTACATAAATGTAAGGGCTTTAGTTTTCATGTTTTATTAAGTCTAACTGAGATTTTGAAAGGAT
GTTTAGCAACAATGGATAAAGAATTATGGATAGAACGAGCTAATGATAGTTTAGTTAAACATTTTTATGAGCAGCAATCT
GACATTGAACAGCGAGAAGGTTTTGAAAGTAAATTAACATTTGGTACTGCGGGTATACGCGGAAAATTCGGTCTTGGTGA
AGGTCGACTTAATAAGTTTACTATTGAAAAATTGGCATTAGGTTTAGCGCGTTATTTAAATGCCCAAACAAACAGTCCAA
CAATAGTCATTCATTATGATATTAGACATCTTTCAACTGAATTCGCCCAAATAATTGCTAATGTATTAGCAAACCATCAA
ATAACAGTTTATTTACCTGATACATATAAAACGACACCGGAATTATCGTTCGCGGTGCGCAATCTTAATACTACTGCTGG
CATTATGATTACAGCAAGTCATAATCCGAAAGACTATAACGGCATCAAAGTATATGGTTCTGATGGTGCGCAATTATCGA
CTGATGCATCTGAGCTTGCAAGTCGTTATATCGAAGAAGTTGGCGATCCATTACAGATTGATATACCTATTTCTAAACAA
AATACATCTTATATCAAGCCTTTTCCGAAATCTGTAACTGATGACTATATGAAACACATTCAAAATATGATTGGCTATAT
TCCTAAATCTGATTTACAAGTTGTGTTCACTAGTTTGCATGGTACAAGTGTTCCGATTGTACCTGAGTTATTACAATCTT
TGAATTTCAATCAATTTAATCTTGTAGAAGCACAATGTAAACCTGATCCGAATTTCAGCTCAGTTCAAAGTGCTAATCCT
GAAGATCATCGCGCTTTTGATCAAGCAGTCGAACTTGCAAATAAAAGTCATGCAGACTTATTAATATCAACTGACCCTGA
TGCAGATCGACTTGGTATTGCTGAACGTGATGCACACGGTCATATCACATATTTTAATGGCAACCAAATTGGTGCGCTGT
TACTTAATTATCGTATTCAACAAACGTCTCAATTACGTCACCGCTTAATGATTCAATCTATTGTAAGTAGTGAGTTAACA
AAGTCATTAGCACGCTATAATAATGTTGAATACAAAGAGGTGCTGACGGGCTTTAAATTTATTGCTCAGGAAATAAGACA
ACTGGATGATCATCAAAATATGATTTTCGCATTTGAAGAGAGTTACGGTTTTCTATCAGAGCCTTTTGTACGTGATAAAG
ATGCCGTACAAATTGTGCCACTCATTATAAAATACGCTTCTGAGTTAAAATTATATGGCAAAACATTGAAAGATGAATTA
GAACAGATTTATCAAACTGTTGGTAGACATGAGGATACATTATTCTCGCATACGCTAGAAGGATTTGAAGGGAAAAAGAA
AATTAATGCAATAATGACCAAATTCCGTTCAAATCCACCGCAAGAGATTCAAGGACTCAAAGTGAAAGCAATTGAAGATT
ATTTAACTAGCGAGGTTTATCATTTGGATAAAGATACAACGTCGCAGATTAATTCTCCTAAATCAAATGTTATTCGTGTC
TTATTTGACGAAGGATTTATCGCTTTACGTCCTTCTGGTACTGAACCTAAAATTAAATTATATGTGTCGTTAAAATGTCC
GAATTTTGATGATGTAGCTCAAAAAATTAATGCGATGATTTTTAGCTAA

Upstream 100 bases:

>100_bases
TTTAAAATCATCTTAATTGTTATTCTATCAAAAATTACAAAACTATATATAAATCAATATTAAAAATTAATATTTTACAT
TCACATGAACGCTCTACTCC

Downstream 100 bases:

>100_bases
TTAAAAATTTTATACATCGAAATATTACATTTCATTTTATGCTTATCAGCCCTTTTGAAACTAGAATCCTTATGTTTTCG
CGTTTTGAAGGGGCTAATTT

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MHFHTHLLYNTCEKYCLGAVFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQS
DIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNSPTIVIHYDIRHLSTEFAQIIANVLANHQ
ITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQ
NTSYIKPFPKSVTDDYMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSVQSANP
EDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELT
KSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDEL
EQIYQTVGRHEDTLFSHTLEGFEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYHLDKDTTSQINSPKSNVIRV
LFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS

Sequences:

>Translated_602_residues
MHFHTHLLYNTCEKYCLGAVFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQS
DIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNSPTIVIHYDIRHLSTEFAQIIANVLANHQ
ITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQ
NTSYIKPFPKSVTDDYMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSVQSANP
EDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELT
KSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDEL
EQIYQTVGRHEDTLFSHTLEGFEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYHLDKDTTSQINSPKSNVIRV
LFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
>Mature_602_residues
MHFHTHLLYNTCEKYCLGAVFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQS
DIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNSPTIVIHYDIRHLSTEFAQIIANVLANHQ
ITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQ
NTSYIKPFPKSVTDDYMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSVQSANP
EDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELT
KSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDEL
EQIYQTVGRHEDTLFSHTLEGFEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYHLDKDTTSQINSPKSNVIRV
LFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also use

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=564, Percent_Identity=32.6241134751773, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI31377548, Length=548, Percent_Identity=31.9343065693431, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1789566, Length=302, Percent_Identity=28.8079470198675, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788361, Length=264, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=565, Percent_Identity=29.9115044247788, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71993878, Length=321, Percent_Identity=31.1526479750779, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323934, Length=558, Percent_Identity=28.1362007168459, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129809, Length=563, Percent_Identity=28.9520426287744, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24651977, Length=442, Percent_Identity=30.316742081448, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24653722, Length=428, Percent_Identity=30.607476635514, Blast_Score=186, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 68349; Mature: 68349

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFHTHLLYNTCEKYCLGAVFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLAL
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCCCCCHHHHHHHHHH
GLARYLNAQTNSPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVR
HHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHH
NLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQ
CCCCCEEEEEEECCCCCCCCCEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCC
NTSYIKPFPKSVTDDYMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFN
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCHHHHHHHHCCCCCEE
LVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHG
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCCCCCCCC
HITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKF
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDEL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIYQTVGRHEDTLFSHTLEGFEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVY
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHH
HLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMI
CCCCCCHHHCCCCHHHEEEEEEECCEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHH
FS
CC
>Mature Secondary Structure
MHFHTHLLYNTCEKYCLGAVFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLAL
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCCCCCHHHHHHHHHH
GLARYLNAQTNSPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVR
HHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHH
NLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQ
CCCCCEEEEEEECCCCCCCCCEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCC
NTSYIKPFPKSVTDDYMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFN
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCHHHHHHHHCCCCCEE
LVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHG
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCCCCCCCC
HITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKF
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDEL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIYQTVGRHEDTLFSHTLEGFEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVY
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHH
HLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMI
CCCCCCHHHCCCCHHHEEEEEEECCEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHH
FS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA