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The map label for this gene is hlgA

Identifier: 57650963

GI number: 57650963

Start: 2478564

End: 2479493

Strand: Direct

Name: hlgA

Synonym: SACOL2419

Alternate gene names: 57650963

Gene position: 2478564-2479493 (Clockwise)

Preceding gene: 57650962

Following gene: 57650964

Centisome position: 88.22

GC content: 32.8

Gene sequence:

>930_bases
ATGATTAAAAATAAAATATTAACAGCAACTTTAGCAGTTGGTTTAATAGCCCCTTTAGCCAATCCATTTATAGAAATTTC
TAAAGCAGAAAATAAGATAGAAGATATCGGCCAAGGTGCAGAAATCATCAAAAGAACACAAGACATTACTAGCAAACGAT
TAGCTATAACTCAAAACATTCAATTTGATTTTGTAAAAGATAAAAAATATAACAAAGATGCCCTAGTTGTTAAGATGCAA
GGCTTCATTAGCTCTAGAACAACATATTCAGACTTAAAAAAATATCCATATATTAAAAGAATGATATGGCCATTTCAATA
TAATATCAGTTTGAAAACGAAAGACTCTAATGTTGATTTAATTAATTATCTTCCTAAAAATAAAATTGATTCAGCAGATG
TTAGTCAGAAATTAGGCTATAATATCGGCGGAAACTTCCAATCAGCGCCATCAATCGGAGGCAGTGGCTCATTCAACTAC
TCTAAAACAATTAGTTATAATCAAAAAAACTATGTTACTGAAGTAGAAAGTCAGAACTCTAAAGGTGTTAAATGGGGAGT
GAAAGCAAATTCATTCGTTACACCGAATGGTCAAGTATCTGCATATGATCAATACTTATTTGCACAAGACCCAACTGGTC
CAGCAGCACGAGACTATTTCGTCCCAGATAATCAACTACCTCCTTTAATTCAAAGTGGCTTTAATCCATCATTTATTACA
ACATTGTCACACGAAAGAGGTAAAGGTGATAAAAGCGAGTTTGAAATCACTTACGGCAGAAACATGGATGCTACATATGC
TTACGTGACAAGACATCGTTTAGCCGTTGATAGAAAACATGATGCTTTTAAAAACCGAAACGTTACAGTTAAATATGAAG
TGAACTGGAAAACACATGAAGTAAAAATTAAAAGCATCACACCTAAGTAA

Upstream 100 bases:

>100_bases
TGATAGTAATTAACTTTTAACGAACAGTTAATTCGAAAACGCTTACAAATGGATTATTATATATATGAACTTAAAATTAA
ATAGAAAGAAAGTGATTTCT

Downstream 100 bases:

>100_bases
ACAGTTCAATCATCTTAAAAAATCCTGGGACACTTCATACTTGTCTCAGGATTTTTTAACAAATTGAATCAGCCTCATAA
CATTAAATTATTTTATCGTA

Product: gamma-hemolysin, component A

Products: NA

Alternate protein names: H-gamma-2; H-gamma-II

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQ
GFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNY
SKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFIT
TLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK

Sequences:

>Translated_309_residues
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQ
GFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNY
SKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFIT
TLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>Mature_309_residues
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQ
GFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNY
SKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFIT
TLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLGA_STAAC (Q5HDD6)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187221.1
- ProteinModelPortal:   Q5HDD6
- SMR:   Q5HDD6
- STRING:   Q5HDD6
- EnsemblBacteria:   EBSTAT00000010377
- GeneID:   3238445
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2419
- TIGR:   SACOL2419
- eggNOG:   NOG123668
- GeneTree:   EBGT00050000023901
- HOGENOM:   HBG693142
- OMA:   MAPLANP
- ProtClustDB:   CLSK885582
- BioCyc:   SAUR93062:SACOL2419-MONOMER
- GO:   GO:0019835
- GO:   GO:0009405
- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183
- PRINTS:   PR01468
- TIGRFAMs:   TIGR01002

Pfam domain/function: PF07968 Leukocidin; SSF56959 Leukocidin/Porin

EC number: NA

Molecular weight: Translated: 34956; Mature: 34956

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNI
CCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECC
QFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDL
EEEEEECCCCCCCEEEEEEECHHCCCCCHHHHHHCCHHHHEECCEEEEEEEEECCCCCEE
INYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNS
EECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCC
KGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFIT
CCEEEECCCCCEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCEEE
TLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHE
EECCCCCCCCCCEEEEEECCCCCCEEHEEHHHHHHHCCCHHHHCCCCEEEEEEECCEEEE
VKIKSITPK
EEEEEECCC
>Mature Secondary Structure
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNI
CCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECC
QFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDL
EEEEEECCCCCCCEEEEEEECHHCCCCCHHHHHHCCHHHHEECCEEEEEEEEECCCCCEE
INYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNS
EECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCC
KGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFIT
CCEEEECCCCCEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCEEE
TLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHE
EECCCCCCCCCCEEEEEECCCCCCEEHEEHHHHHHHCCCHHHHCCCCEEEEEEECCEEEE
VKIKSITPK
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA