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The map label for this gene is moaE

Identifier: 57650856

GI number: 57650856

Start: 2327278

End: 2327724

Strand: Reverse

Name: moaE

Synonym: SACOL2264

Alternate gene names: 57650856

Gene position: 2327724-2327278 (Counterclockwise)

Preceding gene: 57652205

Following gene: 57650855

Centisome position: 82.85

GC content: 36.02

Gene sequence:

>447_bases
ATGAAACAATTTGAAATCGTGACAGAACCGATACAAACAGAACAATATCGTGAATTCACTATAAATGAATATCAAGGTGC
AGTAGTTGTTTTTACCGGTCATGTTCGCGAATGGACTAAAGGCGTCAAAACGGAATATTTAGAATATGAAGCGTATATTC
CAATGGCTGAAAAGAAATTGGCACAAATTGGAGATGAAATAAATGAAAAATGGCCTGGAACGATAACGAGTATTGTTCAT
AGAATAGGGCCATTACAAATTTCAGATATCGCTGTATTAATTGCGGTTTCTTCACCGCATCGTAAAGATGCCTATCGAGC
AAATGAATATGCAATTGAGCGTATAAAAGAAATTGTTCCGATTTGGAAAAAAGAAATTTGGGAAGATGGTTCAAAATGGC
AAGGGCATCAAAAAGGGAATTATGAAGAAGCGAAGAGGGAGGAATAA

Upstream 100 bases:

>100_bases
AATGTAAGGGAGCATGAAGATTTTACAGCATTTGAGCAATGGTTATTAAATAAAATTAAAAATGATTGTGATACACAATT
AACATAGAGGATTGAAATGA

Downstream 100 bases:

>100_bases
GAGAGATGAAGGTACTTTACTTCGCAGAAATTAAAGATATATTACAAAAAGCACAGGAAGATATTGTGCTTGAACAAGCA
TTGACTGTACAACAATTTGA

Product: molybdenum cofactor biosynthesis protein E

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVH
RIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE

Sequences:

>Translated_148_residues
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVH
RIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>Mature_148_residues
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVH
RIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=129, Percent_Identity=40.3100775193798, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1787003, Length=133, Percent_Identity=36.0902255639098, Blast_Score=91, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17509279, Length=122, Percent_Identity=37.7049180327869, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356259, Length=137, Percent_Identity=35.7664233576642, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE_STAAC (Q5HDT6)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187071.1
- ProteinModelPortal:   Q5HDT6
- SMR:   Q5HDT6
- STRING:   Q5HDT6
- EnsemblBacteria:   EBSTAT00000010763
- GeneID:   3237589
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2264
- TIGR:   SACOL2264
- eggNOG:   COG0314
- GeneTree:   EBGT00050000025003
- HOGENOM:   HBG460564
- OMA:   PHRSEAF
- ProtClustDB:   CLSK885855
- BioCyc:   SAUR93062:SACOL2264-MONOMER
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40
- PANTHER:   PTHR23404:SF2

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 17339; Mature: 17339

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: BINDING 44-44 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKL
CCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHH
AQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVP
HHHHHHHHCCCCCHHHHHHHHHCCCEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
IWKKEIWEDGSKWQGHQKGNYEEAKREE
HHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKL
CCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHH
AQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVP
HHHHHHHHCCCCCHHHHHHHHHCCCEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
IWKKEIWEDGSKWQGHQKGNYEEAKREE
HHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA