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The map label for this gene is gyaR [H]

Identifier: 57650652

GI number: 57650652

Start: 1983361

End: 1984311

Strand: Reverse

Name: gyaR [H]

Synonym: SACOL1920

Alternate gene names: 57650652

Gene position: 1984311-1983361 (Counterclockwise)

Preceding gene: 57650653

Following gene: 57650651

Centisome position: 70.63

GC content: 30.6

Gene sequence:

>951_bases
ATGAAAGTTGTTGGGTTAAATCGTATGCGTGAAGTTGAAACTGAATTACAACAACGCTTTTCAGATTTAGATTTTAAATT
TTATAAAAAAGCATCAGAAATACCTGAGAGCGACTTGGCTGATTTAGATATATTAGTTGGTTATGATGGCGGTATCAATG
AGGCATTTTTACGACGTTGCCCGAATTTAAAATGGATTGCATGGTTTGCAACGGGTGTAAATACATTGCCGTTAGATTAT
ATTGCAGATCACGGCATACTTTTAACTAATGGAAAAGGTGTTCAAGCTAAACAATTATCTGAATACATTTTAGCTTTCAT
TTTAGATGATTATAAAAAGATGAAACTATCATATGATAACCAACGACAACATATATATGATTCGAAAATAACTGGTAAAC
GCCTATCAGGACAAACAGTTTTATTTTTAGGTACAGGTGCAATTGCTACTAGAACTGCGAAGTTAGCAAAGGCTTTTAAT
ATGAATTTAATTGGTCTGAGCAAGTCAGGTCAGAACAAAGATGAGTTTGACGAGATATATACTATCGAATCACTTGAAAG
CACATTACCAAATGCTGACATTATTATAAATGCTTTACCAGAAACGCAAGAAACGATTCATTTACTAAAGAAAAAACATT
TTGAATTAATGAAAGATGAAGCACTTTTTATAAATATAGGACGAGGTAGCATAGTTAAAGAAGCGCTCTTAATAGAAGTA
TTAAAAAGTAAAGTTATTCGACATGCATATTTAGATGTGTTTGAAAATGAACCTTTGAAACCTAATCATGAATTATATGA
ATTGGATAATGTAACTATAACAGCGCATATAACTGGTAATGATTATGAAGCAAAGTATGACTTATTAGATATTTTTAAAA
ACAATCTAGTTAATTTTCTCAATAAGAATGGTATAATTGAGAATGAAGTTGATGCTAAAAAAGGCTATTAA

Upstream 100 bases:

>100_bases
CTTTTATAATAGATGAACAAGGTAAAGTATTAGATGTTATCGAGAAGGTTAAGGTTAAAACACAAATAGAAGAACTTAAA
AACATTTTGGGGTGACATAT

Downstream 100 bases:

>100_bases
ATGAAATCATCATGTAAATATTGACACGCGCGCAATACTACAGTTATATTTATAGTAAGTAATAATAATTATTATATAAG
AAAGATGGTGATATAGATGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDY
IADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
LKSKVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGIIENEVDAKKGY

Sequences:

>Translated_316_residues
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDY
IADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
LKSKVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGIIENEVDAKKGY
>Mature_316_residues
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDY
IADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
LKSKVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGIIENEVDAKKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=28.6290322580645, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082289, Length=299, Percent_Identity=26.7558528428094, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=24.7933884297521, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789279, Length=242, Percent_Identity=25.6198347107438, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787645, Length=202, Percent_Identity=25.2475247524752, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=27.8008298755187, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=287, Percent_Identity=25.4355400696864, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=297, Percent_Identity=24.9158249158249, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=30.4597701149425, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=164, Percent_Identity=28.6585365853659, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=26.4, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=22.5296442687747, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571528, Length=178, Percent_Identity=29.2134831460674, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35954; Mature: 35954

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRC
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHC
PNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDN
CCCEEEEEEECCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIY
CHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHE
TIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
EHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LKSKVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
NKNGIIENEVDAKKGY
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRC
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHC
PNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDN
CCCEEEEEEECCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIY
CHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHE
TIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
EHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LKSKVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
NKNGIIENEVDAKKGY
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]